Lys-gamma3-MSH: A global regulator of hormone sensitive lipase activity?

This short review will provide a brief overview of the role of γ-MSH in the adrenal and the more recent report that it can also regulate HSL function in the adipocyte. We also present some preliminary data purporting a direct role for Lys-γ3-MSH in the regulation of HSL phosphorylation in the heart. Taken together these data suggest that γ-MSH peptides might play a more widespread role in lipid and cholesterol utilization.