کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8478841 | 1551256 | 2018 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Adrenergic β receptor activation in the basolateral amygdala, which is intracellular Zn2+-dependent, rescues amyloid β1-42-induced attenuation of dentate gyrus LTP
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
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چکیده انگلیسی
On the basis of the evidence that the basolateral amygdala (BLA) modulates hippocampal memory processes via synaptic plasticity, here we report that adrenergic β receptor activation in the BLA rescues amyloid β1-42 (Aβ1-42)-induced attenuation of long-term potentiation (LTP) at perforant pathway-dentate granule cell (DGC) synapses. When 500â¯Î¼M isoproterenol (2â¯Î¼l), an adrenergic β receptor agonist, was injected into the BLA 20â¯min before LTP induction, LTP was enhanced. Isoproterenol-mediated enhancement of LTP was blocked by co-injection with 100â¯Î¼M ZnAF-2DA, an intracellular Zn2+ chelator, suggesting that intracellular Zn2+ is required for the intracellular signaling cascade after adrenergic β receptor activation in the BLA. Aβ1-42-induced attenuation of LTP, which was induced by Aβ1-42 injection into the dentate gyrus 60â¯min before LTP induction, was rescued by isoproterenol injection into the BLA 20â¯min before LTP induction, but not by 500â¯Î¼M phenylephrine (2â¯Î¼l), an adrenergic α1 receptor agonist, injection into the BLA, which did not enhance LTP unlike the case of isoproterenol injection. Interestingly, Aβ1-42-induced attenuation of LTP was also rescued by 100â¯Î¼M isoproterenol injection into the BLA 20â¯min before LTP induction, which did not enhance LTP. The present study demonstrates that adrenergic β receptor activation in the BLA, which is linked with intracellular Zn2+ signaling, rescues Aβ1-42-induced attenuation of dentate gyrus LTP. It is likely that adrenergic β receptor activation in the BLA is a strategy for rescuing Aβ1-42-induced cognitive decline that is associated with hippocampal synaptic plasticity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurochemistry International - Volume 120, November 2018, Pages 43-48
Journal: Neurochemistry International - Volume 120, November 2018, Pages 43-48
نویسندگان
Haruna Tamano, Mitsuyasu Kubota, Yuki Fujise, Ryota Shimaya, Ryusei Itoh, Miki Suzuki, Paul A. Adlard, Ashley I. Bush, Atsushi Takeda,