کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8513958 | 1556501 | 2017 | 30 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Impact of FDA-Approved Drugs on the Prostaglandin Transporter OATP2A1/SLCO2A1
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کلمات کلیدی
INHNSAID6-CFARBphorbol 12-myristate 13-acetateSTI6-carboxyfluorescein - 6-کربوکسی فلوئورسینPMA - LDC هاDrug effects - اثرات مواد مخدرInhibitor - بازدارندهStimulator - تحریک کنندهOrganic anion-transporting polypeptide transporters - حمل و نقل پلی پپتید های آنیونی ارگانیزمTransport - حمل و نقل یا ترابریnonsteroidal anti-inflammatory drug - داروهای ضد التهابی غیر استروئیدیStructure-activity relationship (SAR) - ساختار-فعالیت (SAR)Pharmacodynamics - فارماکودینامیکPharmacokinetics - فارماکوکینتیکAngiotensin receptor blocker - مسدود کننده گیرنده آنژیوتانسینcysteinyl leukotriene receptor - گیرنده cysteinyl leukotriene
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
To understand interaction of drugs with the prostaglandin transporter OATP2A1/SLCO2A1 that regulates disposition of prostaglandins, we explored the impact of 636 drugs in an FDA-approved drug library on 6-carboxyfluorescein (6-CF) uptake by OATP2A1-expressing HEK293 cells (HEK/2A1). Fifty-one and 10 drugs were found to inhibit and enhance 6-CF uptake by more than 50%, respectively. Effect of the 51 drugs on 6-CF uptake was positively correlated with that on PGE2 uptake (r = 0.64, p < 0.001). Among those, 5 drugs not structurally related to prostaglandins, suramin, pranlukast, zafirlukast, olmesartan medoxomil, and losartan potassium, exhibited more than 90% PGE2 uptake inhibition. Inhibitory affinity of suramin to OATP2A1 was the highest (IC50,2A1 of 0.17 μM), and its IC50 values to MRP4-mediated PGE2 transport (IC50,MRP4) and PGE2 synthesis in human U-937 cells treated with phorbol 12-myristate 13-acetate (IC50,Syn) were 73.6 and 336.7 times higher than IC50,2A1, respectively. Moreover, structure-activity relationship study in 29 nonsteroidal anti-inflammatory drugs contained in the library displayed inhibitory activities of anthranilic acid derivatives, but enhancing effects of propionic acid derivatives. These results demonstrate that suramin is a potent selective inhibitor of OATP2A1, providing a comprehensive information about drugs in clinical use that interact with OATP2A1.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 106, Issue 9, September 2017, Pages 2483-2490
Journal: Journal of Pharmaceutical Sciences - Volume 106, Issue 9, September 2017, Pages 2483-2490
نویسندگان
Shunsuke Kamo, Takeo Nakanishi, Rika Aotani, Yoshinobu Nakamura, Tomoka Gose, Ikumi Tamai,