کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8524844 | 1557938 | 2018 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Aliskiren: Preclinical evidence for the treatment of hyperproliferative skin disorders
ترجمه فارسی عنوان
آلیسیرن: شواهد پیش از موعد درمان اختلالات پوستی پرخطر
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کلمات کلیدی
TNFPCNANAGinfRASBSA - BSAMPO - DFON-acetyl-β-d-glucosaminidase - N-acetyl-β-d-glycosaminidasebovine serum albumin - آلبومین سرم گاوaliskiren - آلیسیرنProliferating Cell Nuclear Antigen - آنتیژن هسته ای تکثیر سلولیAngiotensin II - آنژیوتانسین دوinflammation - التهاب( توروم) interferon - اینترفرونinterleukin - اینترلوکینCell proliferation - تکثیر سلولیAng II - دومRenin - رینینrenin-angiotensin system - سیستم رنین-آنژیوتانسینtumor necrosis factor - فاکتور نکروز تومورmyeloperoxidase - میلوپراکسیداز Psoriasis - پسوریازیس
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
تومور شناسی
چکیده انگلیسی
Psoriasis is a complex inflammatory and hyperproliferative skin disease. The pathogenesis and mechanisms involved are not completely understood, which makes treatment a difficult issue. Angiotensin II, the most active peptide of the renin-angiotensin system, seems to be involved in processes related to psoriasis pathogenesis, such as inflammation and cell proliferation. The aim of this study was to investigate the influence of renin inhibition on inflammation parameters and keratinocyte proliferation in a mouse model of chronic skin inflammation induced by croton oil. Aliskiren had anti-inflammatory effects by reducing levels of tumor necrosis factor-α and interleukin -6, and by inhibiting myeloperoxidase activity. Aliskiren also showed antiproliferative activity by reducing epidermal hyperplasia and proliferating cell nuclear antigen levels. Aliskiren treatment did not induce alterations in the cardiovascular system, normal skin thickness, and organ weight. These results suggest that aliskiren could be a valuable tool to be incorporated in the treatment of hyperproliferative and inflammatory skin disorders such as psoriasis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomedicine & Pharmacotherapy - Volume 104, August 2018, Pages 151-157
Journal: Biomedicine & Pharmacotherapy - Volume 104, August 2018, Pages 151-157
نویسندگان
Priscila Lúcia Pawloski, Camila Guimarães Moreira, Cintia Delai Silva Horinouchi, Daniel Fernandes, Luiz Renato Júnior, Willian Machado, Daniela Almeida Cabrini, Michele Dietrich, Kátia Paludo, Michel Fleith Otuki,