کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8526460 1557945 2018 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Retinoic acid-loaded alginate microspheres as a slow release drug delivery carrier for intravitreal treatment
ترجمه فارسی عنوان
میکروسکپ های آلژینات با اسید رتینوئیک اسید به عنوان یک دارنده تحویل دارو آرام برای درمان داخل ادراری
کلمات کلیدی
ویتریوتراپی پرولیفراتیو، اسید رتینوئیک، میکرون های آلژینات سدیم، تحویل مواد مخدر،
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
چکیده انگلیسی
Pharmacotherapy were the mainstream methods for the treatment of proliferative vitreoretinopathy (PVR), one of the leading causes of blindness. Due to the negligible side-effects, retinoic acid (RA) was considered to be a promising candidate drug. However, it was still a challenge to deliver drugs into vitreous with both long-term efficiency and biosafety. Sodium alginate was considered to be an excellent drug carrier owing to its controlled size, good biocompatibility and degradability. Based on a one-time synthetic strategy of preparing RA-sodium alginate microspheres, the study was aimed to establish a non-toxic and effective RA slow release platform. The prepared microspheres were smoothly round and relatively homogenous with an average diameter of 95.7 ± 9.6 μm. RA release rate from RA-MS was assessed in vitro by UV spectrometry and in vivo by high performance liquid chromatography, achieving a steady, long-term and effective level of RA. The biocompatibility of RA-MS was further confirmed through histology using HE staining and fundus microscope, finding no inflammation and other toxic response. Collectively, it could be concluded that RA-MS possessed a great potential in retinal PVR treatment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomedicine & Pharmacotherapy - Volume 97, January 2018, Pages 722-728
نویسندگان
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