کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8534694 | 1560522 | 2018 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Resistance training attenuates inflammation and the progression of renal fibrosis in chronic renal disease
ترجمه فارسی عنوان
تمرینات مقاومت باعث کاهش التهاب و پیشرفت فیبروز کلیوی در بیماری مزمن کلیه می شود
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کلمات کلیدی
سیتوکین ها، التهاب آسیب کلیوی، استحکام، آموزش قدرت،
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی
Patients with chronic kidney disease (CKD) have progressive renal fibrosis, inflammation, and reduced muscle mass and strength. Resistance training (RT) has been suggested to mitigate the loss of muscle mass, of strength and the inflammation in CKD, but the mechanisms are unknown. The aim of this study was to evaluate the influence of RT on renal fibrosis, renal cytokine expression, creatine kinase levels, and muscle mass and strength in CKD rats. A CKD model was obtained by 5/6 nephrectomy (Nx). Fifteen 8-week-old male rats were divided into 3 groups: Sham (control), Nx SED (CKD sedentary) and Nx RT (CKD trained). The RT consisted of ladder climbing at 70% of the animal's maximal carrying capacity for 10â¯weeks. Muscle strength, creatine kinase levels, renal fibrosis and mRNA interleukin (IL)-4, IL-6 and IL-10 were analyzed after the RT protocol. There was significant improvement in the muscle strength and creatine kinase levels in the Nx RT group. Moreover, renal fibrosis and inflammation were attenuated, with increased IL-4 and IL-10 expression and reduced IL-6 expression in the Nx RT group compared with that in the Nx SED group. No difference in muscle mass was observed among the groups. In conclusion, RT was effective in reducing fibrosis and inflammation, in addition to increasing muscle strength and creatine kinase levels, in rats with CKD, independent of muscle mass.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Life Sciences - Volume 206, 1 August 2018, Pages 93-97
Journal: Life Sciences - Volume 206, 1 August 2018, Pages 93-97
نویسندگان
Michel Kendy Souza, Rodrigo Vanerson Passos Neves, Thiago Santos Rosa, Marcos Antônio Cenedeze, Simone Costa A. Arias, Clarice Kazue Fujihara, Reury Frank Pereira Bacurau, Niels Olsen Saraiva Câmara, Milton Rocha Moraes, Alvaro Pacheco e Silva Filho,