کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8536813 | 1560919 | 2018 | 95 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Chronopathophysiological implications of orexin in sleep disturbances and lifestyle-related disorders
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کلمات کلیدی
LPSNAFLDOX2RDORALepRbNon-Exercise Activity ThermogenesisNEATSIDSLHAMCHSCNBNSTDMNVDRNREMOX1RPI3KAβHFDBATNREMdual orexin receptor antagonistCeA - CEAamyloid β - آمیلوئید βbrown adipose tissue - بافت چربی قهوه ایnon-alcoholic fatty liver disease - بیماری کبدی چربی غیر الکلیrapid eye movement - حرکت سریع چشمnon-rapid eye movement - حرکت سریع چشم نیستHigh fat diet - رژیم غذایی با چربی بالاSudden Infant Death Syndrome - سندرم مرگ ناگهانی نوزادendoplasmic reticulum - شبکه آندوپلاسمی phosphoinositide 3-kinase - فسفینوزیتید 3-کینازlocus coeruleus - لوکوس سیرولئوسlipopolysaccharide - لیپوپلی ساکاریدinterstitial fluid - مایع بینابینیCSF - مایع مغزی نخاعیCerebrospinal fluid - مایع مغزی نخاعیlateral hypothalamic area - منطقه هیپوتالاموس جانبیHPA - میلی بار یا هکتوپاسکالISF - نیروهای امنیتی عراقbed nucleus of the stria terminalis - هسته تخت ترمینال های استریdorsal raphe nucleus - هسته رافهcentral nucleus of amygdala - هسته مرکزی آمیگدالdorsal motor nucleus of the vagus - هسته موتور پشتی وحشیSuprachiasmatic nucleus - هستههای سوپراکیاسماتیکmelanin-concentrating hormone - هورمون متمرکز کننده ملانینhypothalamic-pituitary-adrenal - هیپوتالاموس-هیپوفیز-آدرنالOrexin 1 receptor - گیرنده اورکسین 1Orexin 2 receptor - گیرنده اورکسین 2Leptin receptor - گیرنده لپتین
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Sleep, a mysterious behavior, has recently been recognized as a crucial factor for health and longevity. The daily sleep/wake cycle provides the basis of biorhythms controlling whole-body homeostasis and homeodynamics; therefore, disruption of sleep causes several physical and psychological disorders, including cardiovascular disease, obesity, diabetes, cancer, anxiety, depression, and cognitive dysfunction. However, the mechanism linking sleep disturbances and sleep-related disorders remains unknown. Orexin (also known as hypocretin) is a neuropeptide produced in the hypothalamus. Central levels of orexin oscillate with the daily rhythm and peak at the awake phase. Orexin plays a major role in stabilizing the wakefulness state. Orexin deficiency causes sleep/wake-state instability, resulting in narcolepsy. Hyper-activation of the orexin system also causes sleep disturbances, such as insomnia, and hence, suvorexant, an orexin receptor antagonist, has been clinically used to treat insomnia. Importantly, central actions of orexin regulate motivated behaviors, stress response, and energy/glucose metabolism by coordinating the central-autonomic nervous systems and endocrine systems. These multiple actions of orexin maintain survival. However, it remains unknown whether chronopharmacological interventions targeting the orexin system ameliorate sleep-related disorders as well as sleep in humans. To understand the significance of adequate orexin action for prevention of these disorders, this review summarizes the physiological functions of daily orexin action and pathological implications of its mistimed or reduced action in sleep disturbances and sleep-related disorders (lifestyle-related physical and neurological disorders in particular). Timed administration of drugs targeting the orexin system may prevent lifestyle-related diseases by improving the quality of life in patients with sleep disturbances.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology & Therapeutics - Volume 186, June 2018, Pages 25-44
Journal: Pharmacology & Therapeutics - Volume 186, June 2018, Pages 25-44
نویسندگان
Hiroshi Tsuneki, Tsutomu Wada, Toshiyasu Sasaoka,