کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8537147 | 1561006 | 2019 | 22 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Serum level of brain-derived neurotrophic factor in Parkinson's disease: a meta-analysis
ترجمه فارسی عنوان
سطح سرمی عامل فاکتور نوروتروفیک در مغز در بیماری پارکینسون: یک متاآنالیز
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
چکیده انگلیسی
Brain-derived neurotrophic factor (BDNF), a critical modulator in the neurodevelopment and maintenance of both central and peripheral nervous systems, is regarded as a potential therapeutic target of Parkinson's disease (PD). However, its association with PD remains unclear and the data are inconsistent. To explore the correlation, studies reporting BDNF levels in PD patients and healthy controls are searched and a sample of 1496 participants are pooled in the meta-analysis, demonstrating significantly decreased serum levels of BDNF in PD patients when compared with the healthy controls (SMDâ¯=â¯â1.03; 95% CI [â1.83, â0.23]; Pâ¯=â¯.012). Meta-regression analysis indicates gender is an important confounding factor (Adj R2â¯=â¯69.20%, pâ¯=â¯.004, I2 resâ¯=â¯90.64%), whereas age (Adj R2â¯=â¯11.91%, Pâ¯=â¯.95, I2 resâ¯=â¯96.86%), H-Y stages of PD progression (Adj R2â¯=â¯â30.18%, Pâ¯=â¯.612, I2 resâ¯=â¯96.62%) and MoCA score assessed cognitive impairment (Adj R2â¯=â¯2.18%, Pâ¯=â¯.517, I2 resâ¯=â¯64.41%) show few moderating effects. The research provides evidence of moderate quality that blood levels of BDNF are decreased in PD patients despite various influencing factors, supporting an association between decreased level of peripheral BDNF and PD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 88, 10 January 2019, Pages 168-174
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 88, 10 January 2019, Pages 168-174
نویسندگان
Lina Jiang, Hainan Zhang, Chunyu Wang, Fengyu Ming, Xiaoliu Shi, Mei Yang,