کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8548525 | 1561737 | 2017 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Flavonoids as detoxifying and pro-survival agents: What's new?
ترجمه فارسی عنوان
فلاونوئیدها به عنوان عوامل ضد سم زدایی و حمایت از زنده ماندن: چه چیزی جدید است؟
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کلمات کلیدی
فلاونوئیدها، سم زدایی، ضد اکسید کننده ها، عصاره گیاهی، واکنش استرس اکسیداتیو،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
چکیده انگلیسی
The role of flavonoids in the survival machinery of cells has come in the spotlight due to the recent evidence of their effect on the relationship mitochondria-ER stress-proteasome, including the intracellular mechanisms of autophagy and apoptosis. Numerous experimental animal investigations and even human clinical studies have highlighted the major role of these natural compounds in the economy of life and their deep relationship with autotrophic organisms in the evolutionary space. Their role as anti-oxidant and oxidative stress preventive molecules has to date been investigated extensively in the literature. Despite this great amount of promising evidence, many concerns, however, remain, most of which dealing with biochemistry, bioavailability, pharmacokinetics, and interaction of flavonoids with gut microbiome, issues that make difficult any good attempt to introduce these molecules in the human healthcare systems as possible, encouraging therapeutic substances. This review tries to address and elucidate these items.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 110, December 2017, Pages 240-250
Journal: Food and Chemical Toxicology - Volume 110, December 2017, Pages 240-250
نویسندگان
Geir Bjørklund, Maryam Dadar, Salvatore Chirumbolo, Roman Lysiuk,