کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8552710 | 1562269 | 2018 | 36 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The link of organophosphorus pesticides with neurodegenerative and neurodevelopmental diseases based on evidence and mechanisms
ترجمه فارسی عنوان
پیوند سموم ارگانوفسفره با بیماری های نورودژنراتیو و بیماری های عصبی مبتنی بر شواهد و مکانیسم ها
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کلمات کلیدی
BChEOPIDNbutyrylcholinesterasePONROS - ROSpesticides - آفتکشهاAChE - آهیattention deficit hyperactivity disorder - اختلال کمتوجّهی _ بیشفعالیNeurodevelopmental disorders - اختلالات عصبی توسعهOrganophosphorus - ارگانوفسفورAcetylcholinesterase - استیل کولین استرازamyotrophic lateral sclerosis - اسکلروز جانبی آمیوتروفیکADHD - بیشفعالیAlzheimer disease - بیماری آلزایمرALS - بیماری اسکلروز جانبی آمیوتروفیکNeurodegenerative diseases - بیماری های نوروژنیکParkinson disease - بیماری پارکینسونEnvironmental toxicology - سم شناسی محیط زیستOrganophosphorus-induced delayed neuropathy - نوروپاتی تاخیر ناشی از اتانول فسفرParaoxonase - پاراکسونازReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
Organophosphorus (OP) compounds have been known as the most widely used pesticides during the past half century and there have been a huge body of literature regarding their association with human chronic diseases. Neurodegenerative and neurodevelopmental disorders including Alzheimer, Parkinson, amyotrophic lateral sclerosis (ALS), attention deficit hyperactivity disorder (ADHD), and autism are among the afflicting neurological diseases which overshadow human life and their higher risk in relation to OP exposures have been uncovered by epidemiological studies. In addition, experimental studies exploring the underlying mechanisms have provided some evidence for involvement of cholinergic deficit, oxidative stress, neuro-inflammation, and epigenetic modifications as the processes which are common in the toxicity of the OP and pathophysiology of the mentioned diseases. In addition, genetic mutations and polymorphisms of different variants of some genes like paraoxonase have been shown to be implicated in both susceptibility to OPs toxicity and neurological diseases. In this article, we reviewed the epidemiological as well as experimental studies evidencing the association of exposure to OPs and incidence of neurodegenerative and neurodevelopmental diseases.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology - Volume 409, 1 November 2018, Pages 44-52
Journal: Toxicology - Volume 409, 1 November 2018, Pages 44-52
نویسندگان
Sara Mostafalou, Mohammad Abdollahi,