کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8626001 | 1568360 | 2018 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Maternal dairy fat diet does not influence neurotrophin levels and cognitive performance in the rat offspring at adult age
ترجمه فارسی عنوان
رژیم چربی لبنیات مادران بر میزان نوروتروفین و عملکرد شناختی در فرزندان موش در سن بالایی تأثیر نمی گذارد
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کلمات کلیدی
CREBRMEWmEALAMUFANGFTrkBBDNF - BDNF یا فاکتور نورونزایی مشتقشده از مغز Arachidonic acid - اسید آراشیدونیکDocosahexanoic acid - اسید داکوساگزناکLinoleic acid - اسید لینولئیکalpha linolenic acid - اسید لینولنیک آلفاNervonic acid - اسید نیتریکPolyunsaturated fatty acids - اسید چرب اشباع نشدهPUFA - اسید چرب چند غیراشباعmonounsaturated fatty acids - اسیدهای چرب غیر اشباعreference memory error - خطای حافظه مرجعworking memory error - خطای حافظه کاریDHA - دوکوساهگزائنوئیک اسیدCognition - شناختbrain derived neurotrophic factor - عامل مغز استخوان مغز استخوان استnerve growth factor - فاکتور رشد عصبvitamin B12 - ویتامین ب۱۲tropomyosin receptor kinase - گیرپور کیناز تروپومیسین
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی تکاملی
چکیده انگلیسی
Cognitive development may be influenced by maternal nutrition especially fats. Indian population is vegetarian and main source of fat is dairy. This study investigates the effect of dairy fat consumption during pregnancy in an animal model on fatty acids, brain neurotrophins (brain derived neurotrophic factor: BDNF; and nerve growth factor: NGF) and cognitive performance in adult offspring. Pregnant Wistar rats were assigned to control (Control C) and four treatment groups: High fat diet (HFD); High fat diet supplemented with omega-3 fatty acids (HFDO); High fat diet deficient in vitamin B12 (HFBD); High fat deficient in vitamin B12 supplemented with omega-3 fatty acids (HFBDO). Half the dams were dissected on d20 of gestation, and the brains of their pups were collected. The remaining dams delivered on d22 of gestation and were assigned to a control diet. The cognitive performance of these adult offspring was assessed at 6 mo of age. Brain fatty acids were comparable to control in the pups at birth and offspring at 6 mo of age. The protein levels of BDNF in the pup brain at birth were lower in both the HFD (pâ<â0.01) and HFBD (pâ<â0.05) groups as compared to control. The mRNA levels of TrK B were lower (pâ<â0.05) in the pup brain at birth in the HFD as compared to control group. In the offspring at 6 mo of age the protein levels of BDNF and NGF in all the treatment groups were similar to that of control. However, the mRNA levels of only BDNF (pâ<â0.01 for both) were higher in the HFBD group as compared to both control and HFD groups. The cognitive performance of the adult offspring from various dietary groups was similar to control. In conclusion, consumption of a maternal high dairy fat diet although lowered the levels of brain BDNF in the pup at birth it does not affect the cognitive health of the adult offspring.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Developmental Neuroscience - Volume 71, December 2018, Pages 18-29
Journal: International Journal of Developmental Neuroscience - Volume 71, December 2018, Pages 18-29
نویسندگان
Shruti Jawale, Sadhana Joshi, Anvita Kale,