کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8648503 | 1570694 | 2018 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Immune-modulation of two BATF3 paralogues in rainbow trout Oncorhynchus mykiss
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کلمات کلیدی
LPSBacterial and viral infectionPhytohaemagglutininBatf3IRFTLRPAMPAP-1bZIPPHAPolyI:C - PolyI: Cpathogen-associated molecular pattern - الگوی مولکولی وابسته به پاتوژنinterferon - اینترفرونIFN - اینترفرون هاinterleukin - اینترلوکینToll-like receptor - تیالآرcluster of differentiation - خوشه تمایزDNA binding domain - دامنه اتصال DNAleucine zipper - زیپ لوسینbasic leucine zipper - زیپ پایه لوسینDendritic cell - سلول دندریتیکTranscription factor - عامل رونویسیRainbow trout - قزل آلای رنگین کمانlipopolysaccharide - لیپوپلی ساکاریدactivator protein 1 - پروتئین فعال کننده 1Polyinosinic:polycytidylic acid - پلی سونیک: پلیسییدیدیل اسیدHead kidney - کلیه سر
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی مولکولی
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چکیده انگلیسی
Basic leucine zipper transcription factor ATF-like (BATF) -3 is a member of the activator protein 1 (APâ1) family of transcription factors and is known to play a vital role in regulating differentiation of antigen-presenting cells in mammals. In this study, two BATF3 homologues (termed BATF3a and BATF3b) have been identified in rainbow trout (Oncorhynchus mykiss). Both genes were constitutively expressed in tissues, with particularly high levels of BATF3a in spleen, liver, pyloric caecae and head kidney. BATF3a was also more highly induced by PAMPs and cytokines in cultured cells, with type II IFN a particularly potent inducer. In rIL-4/13 pre-stimulated cells, the viral PAMPS polyI:C and R848 had the most pronounced effect on BATF3 expression. BATF3 expression could also be modulated in vivo, following infection with Yersinia ruckeri, a bacterial pathogen causing redmouth disease in salmonids, or with the rhabdovirus IHNV. The results suggest that BATF3 may be functionally conserved in regulating the differentiation and activation of immune cells in lower vertebrates and could be explored as a potential marker for comparative investigation of leucocyte lineage commitment across the vertebrate phyla.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Immunology - Volume 99, July 2018, Pages 104-114
Journal: Molecular Immunology - Volume 99, July 2018, Pages 104-114
نویسندگان
Jun Wang, Min Liu, Yang Wu, Sohye Yoon, Abdo Alnabulsi, Fuguo Liu, Clara Fernández-Álvarez, Tiehui Wang, Jason W. Holland, Chris J. Secombes, Jun Zou,