The risk for a first acute coronary syndrome in patients treated with different types of antidepressants: A population based nested case-control study

In this study of patients without prior cardiovascular disease- neither antidepressant group imposed excess risk for ACS, compared to-no treatment. SSRIs treatment seemed safer compared to TCAs in regard of ACS. This study probably adds to our confidence of preferring SSRIs over TCAs in patients without prior cardiovascular disease.