کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8738300 | 1591528 | 2018 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
DEC1/STRA13 is a key negative regulator of activation-induced proliferation of human B cells highly expressed in anergic cells
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کلمات کلیدی
BCRCryoglobulinemiaCFSETLRSmall interfering RNA - RNA تداخل کوچکsiRNA - siRNAAnergy - آنجیProliferation - ترویجToll-like receptor - تیالآرB cells - سلول های BActivation - فعال سازیmixed cryoglobulinemia - مخلوط کریگوگلوبولینمیmarginal zone - منطقه حاشیه ایHepatitis C virus - هپاتیت سیHCV - هپاتیت سیcarboxyfluorescein diacetate succinimidyl ester - کربوکسیفلوورسسین دی سکته سوکسینیمیدیل استرB cell receptor - گیرنده سلول B
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The transcription factor DEC1/STRA13 (also known as BHLHE40 and SHARP2) is involved in a number of processes including inhibition of cell proliferation and delay of cell cycle, and is a negative regulator of B cell activation and development in mice. We show here that, unlike in mice, DEC1/STRA13 expression is induced in human naïve and memory resting B cells by activation through the B-cell receptor (BCR) or Toll-like receptor 9 (TLR9). siRNA silencing of DEC1/STRA13 increases the capacity of activated B cells to perform a high number of divisions after TLR9 ligation. This identifies DEC1/STRA13 as a critical negative regulator of clonal expansion of activated human B cells. We also show that DEC1/STRA13 is upregulated in human anergic CD21low B cells clonally expanded in patients with HCV-associated mixed cryoglobulinemia, which fail to proliferate in response to BCR or TLR9 ligation. siRNA knockdown of DEC1/STRA13, however, fails to restore responsiveness to stimuli in these cells, although it might improve the proliferative capacity in a subset of anergic cells with less pronounced proliferative defect.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Immunology Letters - Volume 198, June 2018, Pages 7-11
Journal: Immunology Letters - Volume 198, June 2018, Pages 7-11
نویسندگان
Alessandro Camponeschi, Laura Todi, Cristina Cristofoletti, Cristina Lazzeri, Maurizio Carbonari, Milica Mitrevski, Ramona Marrapodi, Martina Del Padre, Massimo Fiorilli, Milvia Casato, Marcella Visentini,