کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8837759 | 1612887 | 2018 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Maternal nicotine exposure has severe cross-generational effects on offspring behavior
ترجمه فارسی عنوان
قرار گرفتن در معرض نیکوتین مادر دارای اثرات متقابل نسلی شدید بر رفتار فرزند است
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
چکیده انگلیسی
Our previous studies showed that paternal nicotine exposure can lead to hyperactivity in the offspring. Nevertheless, the cross-generational effects of maternal and biparental nicotine exposure remain unclear. In this study, female and male mice were exposed respectively by nicotine before pregnancy. The maternal pre-pregnancy nicotine exposure led to depression-like behaviors in the F1 offspring. However, after biparental pre-pregnancy nicotine exposure, seventy percentage of the offspring exhibited a depressive phenotype while 20% were hyperactive, and the remaining exhibited no obvious abnormal behavior. The cross-generational effects appeared to be mediated via disruption of the balance between GSK3 and p-GKS3 by nicotine. These results suggested that pre-pregnancy nicotine exposure can induce alterations in the behavior of the offspring, and the cross-generational effects of maternal nicotine exposure were particularly serious.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Brain Research - Volume 348, 1 August 2018, Pages 263-266
Journal: Behavioural Brain Research - Volume 348, 1 August 2018, Pages 263-266
نویسندگان
Meixing Zhang, Wangjie Xu, Guang He, Dong Zhang, Xianglong Zhao, Jingbo Dai, Jiajie Wu, Yong Cao, Zhaoxia Wang, Lianyun Wang, Zhongdong Qiao,