کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8841693 | 1615029 | 2018 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Evaluation of oxidative stress and brain-derived neurotrophic factor levels related to crack-use detoxification
ترجمه فارسی عنوان
ارزیابی استرس اکسیداتیو و میزان فاکتورهای نوروتروف فاکتور مغزی مرتبط با سم زدایی از ترک خوردگی
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
چکیده انگلیسی
Crack is a central nervous system stimulant extracted from the Erythroxylum coca plant. It is considered the most potent and addictive form of cocaine, and its euphoric effects are attained within a few seconds after consumption. Alteration of biological markers of oxidative stress and brain-derived neurotrophic factor (BDNF) could be related to the severity of crack withdrawal symptoms in patients undergoing rehabilitation. Thus, the objective of this study was to evaluate if the crack consumption and the drug detoxification process during 14â¯days in hospitalization regime was able to modify the oxidative status and BDNF levels, in male crack-abstinent patients. The crack detoxification process increased the glutathione (GSH), total thiol content (GST), nitric oxide (NO), and superoxide dismutase (SOD) levels, and reduced the mean BDNF levels. Moreover, a positive correlation was found between the number of hospital admission days and SOD values and between the GST levels and crack-use time after 14â¯days of detoxification. Furthermore, a negative correlation between the frequency of crack use and NO levels on the first day of hospitalization was also found. In conclusion, the results of this study indicated that crack consumption causes increased oxidative stress in drug users and that the detoxification process during 14â¯days was sufficient to improve oxidative parameters and antioxidant defenses of the patients, which could positively contribute to rehabilitation process. In addition, we also observed a great variability in the BDNF levels of the patients during the detoxification process, resulting in a reduction in the mean values of this neurotrophin.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 670, 23 March 2018, Pages 62-68
Journal: Neuroscience Letters - Volume 670, 23 March 2018, Pages 62-68
نویسندگان
Gabriela Elisa Hirsch, Mônica Jaskulski, Henrique Morais Hamerski, Ferando Garcez Porto, Brenda da Silva, Carlos Alberto Mayora Aita, Karla Kroker, Gustavo de Bem Silveira, Paulo Cesar Lock Silveira, Gabriela Trevisan Santos, Jonatas Zeni Klafke,