کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8855166 | 1619012 | 2018 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pregnancy exposure to atmospheric pollution and meteorological conditions and placental DNA methylation
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
شیمی زیست محیطی
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چکیده انگلیسی
The methylation of ADORA2B, a gene whose expression was previously associated with hypoxia and pre-eclampsia, was consistently found here sensitive to atmospheric pollutants. In addition, air pollutants were associated to DMRs pointing towards genes previously implicated in preeclampsia, hypertensive and metabolic disorders. These findings demonstrate that air pollutants exposure at levels commonly experienced in the European population are associated with placental gene methylation and provide some mechanistic insight into some of the reported effects of air pollutants on preeclampsia.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environment International - Volume 118, September 2018, Pages 334-347
Journal: Environment International - Volume 118, September 2018, Pages 334-347
نویسندگان
Emilie Abraham, Sophie Rousseaux, Lydiane Agier, Lise Giorgis-Allemand, Jörg Tost, Julien Galineau, Agnès Hulin, Valérie Siroux, Daniel Vaiman, Marie-Aline Charles, Barbara Heude, Anne Forhan, Joel Schwartz, Florent Chuffart, Ekaterina Bourova-Flin,