Stress-sensitivity and reciprocal associations between stressful events and adolescent temperament

• We model reciprocal stressful life events (SLEs)–temperament associations.
• Moderation of sensitivity genes, the 5HTTLPR and pre/perinatal risk in stress-effects is tested.
• SLEs and temperament traits are associated from childhood to adolescence.
• The direction of the effects differs between temperament traits.
• Main effects of sensitivity genes, but no moderation is found.

This study aimed to elucidate the longitudinal, bidirectional associations between stressful life events (SLEs) and adolescent temperament. Subsequently, the study investigated whether the effects of SLEs on future temperament were moderated by (a) a cumulative sensitivity gene index (b) the 5-HTTLPR (the polymorphism most consistently indicated as a sensitivity genotype) and (c) pre/perinatal risk. Data were used from TRAILS, a large population cohort of Dutch adolescents (n = 1475). Temperament was assessed at 11, 16 and 19 years. Data of SLEs that occurred between age 0–11, 11–16, and 16–19 were captured using interviews. The results indicated that SLEs and temperament traits are associated from childhood to adolescence and that the direction of the effects differed between temperament traits. Whereas SLEs were found to predict subsequent fear, SLEs were predicted by, but not predictive of, shyness and affiliation. For effortful control and frustration a fully reciprocal model was found. The cumulative sensitivity gene index, 5-HTTLPR and the pre/perinatal risk did not moderate the effects of SLEs on future temperament.