Deficient prepulse inhibition in schizophrenia in a multi-site cohort: Internal replication and extension

Schizophrenia-linked PPI deficits were replicable across two multi-site “waves” of subjects collected over 3.5 years. Strict response criteria disproportionately excluded older, male, non-Caucasian patients with low-normal hearing acuity. These findings set the stage for genetic analyses of PPI using the combined COGS wave 1 and 2 cohorts.