کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8965572 | 1646725 | 2018 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Mediterranean diet and platelet-activating factor; a systematic review
ترجمه فارسی عنوان
رژیم مدیترانه و فاکتور فعال کننده پلاکت؛ بررسی سیستماتیک
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کلمات کلیدی
EPAPAF receptorT2DMPAFRPrPPBMCRBCRed blood cells - سلولهای قرمز خونacetyltransferase - استیل ترانسفرازEicosapentaenoic acid - اسید ایکوزاپنتانوئیکdocosahexaenoic acid - اسید داکوزاگزوائونیکcardiovascular disease - بیماری قلب و عروقیCardiovascular diseases - بیماری قلبی-عروقی DHA - دوکوساهگزائنوئیک اسیدType 2 diabetes mellitus - دیابت نوع دوCVD - رسوب دهی شیمیایی بخار Olive oil - روغن زیتونMediterranean diet - رژیم غذایی مدیترانهایperipheral blood mononuclear cells - سلول های تک هسته ای خون محیطیbody mass index - شاخص توده بدنBMI - شاخص توده بدنیPlatelet-activating factor - فاکتور فعال کننده پلاکتLipoprotein-associated phospholipase A2 - فسفولیپاز A2 مرتبط با لیپوپروتئینFish - ماهیPAF - نیروی هوایی پاکستانPlatelet rich plasma - پلاسما غنی از پلاکت
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
Platelet-activating factor (PAF) is a glycerylether lipid and one of the most potent endogenous mediators of inflammation. Through its binding to a well-characterized receptor it initiates a plethora of cellular pro-inflammatory actions participating by this way to the pathology of most chronic diseases, including cardiovascular and renal diseases, CNS decline and cancer. Among the variety of prudent dietary patterns, Mediterranean Diet (MD) is the dietary pattern with the strongest evidence for its ability to prevent the same chronic diseases. In addition, micronutrients and extracts from several components and characteristic food of the MD can favorably modulate PAF's actions and metabolism either directly or indirectly. However, the role of this traditional diet on PAF metabolism and actions has rarely been studied before. This systematic review summarizes, presents and discusses the outcomes of epidemiologic and intervention studies in humans, investigating the relationships between PAF status and MD. Seventeen full-text articles trying to interlink the components of MD and PAF are found and presented. The results are inconsistent due to the variability of the measured indices and methodology followed. However, preliminary results indicate that the characteristic “healthy” components of the MD, especially, cereals, legumes, vegetables, fish and wine can favorably modulate the pro-inflammatory actions of PAF and regulate its metabolism. Larger, well-controlled studies are necessary to elucidate whether the attenuation of PAF actions can mediate the preventive properties of MD against chronic diseases.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Biochemistry - Volume 60, September 2018, Pages 1-10
Journal: Clinical Biochemistry - Volume 60, September 2018, Pages 1-10
نویسندگان
Tzortzis Nomikos, Elizabeth Fragopoulou, Smaragdi Antonopoulou, Demosthenes B. Panagiotakos,