کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
898218 915277 2009 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Analgesic effectiveness of flurbiprofen axetil after uterine curettage on abortion: A randomized controlled trial
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Analgesic effectiveness of flurbiprofen axetil after uterine curettage on abortion: A randomized controlled trial
چکیده انگلیسی

SummaryBackgroundPain after uterine curettage has not been clearly evaluated. This study was designed to investigate the hypothesis that flurbiprofen axetil used prior to curettage on abortion could decrease 50% pain from uterine contraction.MethodsNinety seven ASA physical status I–II patients, undergoing elective uterine apoxesis, were allocated to this randomized double-blind controlled study and assigned into one of two groups (n = 45). In the flurbiprofen group, patients received an i.v. injection of flurbiprofen 50 mg in 5 ml 10 min prior to propofol anesthesia. The control group received the same volume of saline injection. Morphine 0.04 mg/kg was used as the rescue drug for uncontrolled pain. Visual analog scale for analgesia at rest, satisfaction with analgesia, morphine consumption and side effects were recorded.ResultsA total of 87 patients completed the study. The intention-to-treat number of patients was 45 in each group. Flurbiprofen group evidenced effective analgesia (vs. saline P = 0.019), with better satisfaction (P = 0.015), lower incidence of nausea, dizziness and drowsiness, pruritus, dry mouth and uterine bleeding than the saline control. The flurbiprofen group consumed less morphine in 1 h 0.6 mg (interquartile 0.1–1.2), vs. saline group 3.7 mg (interquartile 1.5–4.6) (P = 0.049). The number of patients needed to treat was 2 in the flurbiprofen group.ConclusionPreoperative flurbiprofen axetil 50 mg is a clinically effective analgesic means after uterine curettage on abortion.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acute Pain - Volume 11, Issue 2, June 2009, Pages 43–50
نویسندگان
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