کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8998399 | 1115627 | 2005 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Time-dependent effects of repeated cocaine administration on dopamine transmission in the medial prefrontal cortex
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
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چکیده انگلیسی
The medial prefrontal cortex (mPFC) has been implicated in the development of behavioral sensitization, which is the progressive enhancement of locomotor activity that occurs with repeated administration of psychostimulants. Previous data suggest that mPFC dopamine (DA) transmission may be attenuated in cocaine-sensitized animals, but the onset and duration of this effect have not been investigated. After recovery from stereotaxic surgeries, animals were given four daily injections of saline (1Â ml/kg, i.p.) or cocaine (15Â mg/kg, i.p.) and were subsequently challenged with saline or cocaine after 1, 7 or 30Â d of withdrawal, on which days in vivo microdialysis of the mPFC was conducted simultaneously with monitoring of locomotor activity. Compared to acutely administered controls, the results in cocaine-pretreated animals were as follows: 1Â d of withdrawal was associated with a significant attenuation in cocaine-induced locomotion and mPFC DA overflow; after 7Â d, behavioral sensitization was accompanied by a significant attenuation in cocaine-induced elevations in mPFC DA levels; 30Â d of withdrawal led to the expression of sensitized behaviors paralleled by an augmentation in cocaine-induced mPFC DA. These data suggest that repeated cocaine produces temporally distinct behavioral effects associated with alterations in mPFC DA responsiveness to cocaine that may be involved in the development of behavioral sensitization.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropharmacology - Volume 48, Issue 1, January 2005, Pages 51-61
Journal: Neuropharmacology - Volume 48, Issue 1, January 2005, Pages 51-61
نویسندگان
Jason M. Williams, Jeffery D. Steketee,