کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9109131 | 1154552 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Garlic increases IL-10 and inhibits TNFα and IL-6 production in endotoxin-stimulated human placental explants
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی تکاملی
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چکیده انگلیسی
Preeclampsia is a multisystem disorder manifest by hypertension after 20 weeks' gestation associated with end organ damage, usually proteinuria. The placenta is thought to be pivotal in the pathogenesis of the disease. Both the placenta and the maternal systemic response are characterised by heightened inflammation. Garlic has been shown to have anti-inflammatory and pro-apoptotic properties amongst others. It was hypothesised that treating placental explants with garlic may inhibit the production of inflammatory cytokines (interleukin-6 (IL-6) and tumour necrosis factor (TNFα)) and stimulate the production of anti-inflammatory cytokines (interleukin-10 (IL-10)) by the placental explants. Garlic, we hypothesised, would also stimulate apoptosis in the explants as measured by soluble TNF-related apoptosis-inducing ligand/Apo-2L (sTRAIL) production. Normal placental explants (n = 5) and explants from women who had preeclampsia (n = 4) were cultured in the presence of various garlic concentrations (10-1000 μg/mL). The lowest garlic concentration (10 μg/mL) increased the normal explant production of IL-10 by 29.2% (12.2, 57.5%; p < 0.01) while inhibiting the production of IL-6 by 23.5% (8.9, 32.5%; p < 0.01) (normal explants) and TNFα by 19.4% (4.5, 35.3%; p < 0.05) (preeclamptic explants). Garlic resulted in an increase in IL-10 production at lower doses (normal explants only) and inhibition of the production of IL-10 at higher doses (normal and preeclamptic explants). Garlic also resulted in a dose-dependent reduction of IL-6 and TNFα. Initially there was no change in sTRAIL production; however, at the highest garlic concentrations there was a significant increase in production. We thus conclude that garlic may have an immunomodulatory effect on normal and preeclamptic placentas.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Placenta - Volume 26, Issue 10, November 2005, Pages 828-834
Journal: Placenta - Volume 26, Issue 10, November 2005, Pages 828-834
نویسندگان
A. Makris, C.E. Thornton, B. Xu, A. Hennessy,