کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9198261 1188893 2005 15 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The effect of hypercapnia on the neural and hemodynamic responses to somatosensory stimulation
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب شناختی
پیش نمایش صفحه اول مقاله
The effect of hypercapnia on the neural and hemodynamic responses to somatosensory stimulation
چکیده انگلیسی
Modern non-invasive imaging techniques utilize the coupling between neural activity and changes in blood flow, volume and oxygenation to map the functional architecture of the human brain. An understanding of how the hemodynamic response is influenced by pre-stimulus baseline perfusion is important for the interpretation of imaging data. To address this issue, the present study measured hemodynamics with optical imaging spectroscopy and laser Doppler flowmetry, while multi-channel electrophysiology was used to record local field potentials (LFP) and multi-unit activity (MUA). The response to whisker stimulation in rodent barrel cortex was recorded during baseline (normocapnia) and elevated perfusion rates produced by two levels of hypercapnia (5 and 10%). With the exception of the 'washout' of deoxyhemoglobin, which was attenuated, all aspects of the neural and hemodynamic response to whisker stimulation were similar during 5% hypercapnia to those evoked during normocapnia. In contrast, 10% hypercapnia produced cortical arousal and a reduction in both the current sink and MUA elicited by stimulation. Blood flow and volume responses were reduced by a similar magnitude to that observed in the current sink. The deoxyhemoglobin 'washout', however, was attenuated to a greater degree than could be expected from the neural activity. These data suggest that imaging techniques based on perfusion or blood volume changes may be more robust to shifts in baseline than those based on the dilution of deoxyhemoglobin, such as conventional BOLD fMRI.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 27, Issue 3, September 2005, Pages 609-623
نویسندگان
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