کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9296498 | 1233536 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Alterations of glomerular and extracellular levels of glutathione peroxidase in patients and experimental rats with diabetic nephropathy
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کلمات کلیدی
CCRGPXHbA1cDGsROS - ROSEDTA - اتیلن دی آمین تترا استیک اسید ethylenediaminetetraacetate - اتیلنیدامین تتراسیتSOD - سدSuperoxide dismutase - سوکسوکس دیسموتازHemoglobin A1c - هموگلوبین A1cglutathione peroxidase - گلوتاتیون پراکسیدازDiabetic glomerulosclerosis - گلومرول اسکلروز دیابتیReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
To investigate the status and role of glutathione peroxidase (GPX) in diabetic nephropathy, we measured GPX in the plasma and urine of 14 patients with diabetic glomerulosclerosis (DGS) and measured glomerular GPX immunostaining in these patients and in rats with streptozotocin-induced diabetes of varying duration. Plasma GPX levels were significantly lower in DGS patients than in diabetic patients without nephropathy (P < .05) or normal controls (P < .01). Urinary GPX concentrations were also significantly lower in DGS patients than in diabetic patients without nephropathy or normal controls (both P < .05). Immunostaining of glomerular GPX was significantly less in DGS patients than in normal controls (P < .05) and was negatively correlated with the glomerular sclerosis score and the index of mesangial expansion. Serial examination of glomerular GPX in diabetic rats showed that immunostaining scores for glomerular GPX in rats were significantly lower than those in normal control rats after 1 and 3 months' duration of diabetes, and staining scores were also significantly lower in rats killed after 3 months of diabetes than in those killed after 1 week. In conclusion, our study demonstrates that GPX concentrations in plasma, urine, and glomeruli are decreased in individuals with DGS and that the immunostaining of glomerular GPX decreases progressively.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Laboratory and Clinical Medicine - Volume 145, Issue 4, April 2005, Pages 181-186
Journal: Journal of Laboratory and Clinical Medicine - Volume 145, Issue 4, April 2005, Pages 181-186
نویسندگان
Y.I.-Wen Chiu, Mei-Chuan Kuo, Hung-Tien Kuo, Jer-Ming Chang, Jinn-Yuh Guh, Yung-Hsiung Lai, Hung-Chun Chen,