Lipopolysaccharide-induced experimental immune activation does not impair memory functions in humans

Systemic immune activation occurring together with release of peripheral cytokines can affect behavior and the functioning of the central nervous system (CNS). However, it remains unknown whether and to what extent cognitive functions like memory and attention are affected during transient immune activation. We employed a human endotoxemia model and standardized neuropsychological tests to assess the cognitive effects of an experimental inflammation in two groups of 12 healthy young men before and after intravenous injection of lipopolysaccharide (LPS, Escherichia coli, 0.4 ng/kg) or physiological saline. Endotoxin administration caused a profound transient physiological response with elevations in body temperature, number of circulating neutrophils, and increases in plasma cytokine levels [interleukin (IL)-6, IL-10, tumor necrosis factor (TNF)-α], and concentrations of norepinephrine, ACTH and cortisol. However, these changes in immune and neuroendocrine parameters were not associated with alterations of memory performance, selective attention or executive functions.

Research highlights
► Lipopolysaccharide (LPS) injection increased pro- and anti-inflammatory cytokines in humans.
► Increased levels of cortisol, ACTH, and norepinephrine but not prolactin after LPS injection.
► No effect of LPS injection on memory and cognitive functions in humans.
► High correlation between circulating prolactin levels and attention after injection of LPS.