کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9429321 | 1297039 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Attenuated fever response in mice lacking TRPV1
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Attenuated fever response in mice lacking TRPV1 Attenuated fever response in mice lacking TRPV1](/preview/png/9429321.png)
چکیده انگلیسی
TRPV1, the capsaicin receptor, is expressed not only in nociceptive neurons, but also in other locations, including the hypothalamus. Studies involving systemic or intrahypothalamic capsaicin administration have suggested a role for TRPV1 in body temperature control. To explore this possibility, we examined thermoregulatory responses in TRPV1â/â mice. These mutant animals exhibited no obvious changes in circadian body temperature fluctuation, tolerance to increased (35 °C) or decreased (4 °C) ambient temperature or ethanol-induced hypothermia. In contrast, fever production in response to the bacterial pyrogen, lipopolysaccharide (LPS) was significantly attenuated in TRPV1â/â mice. Despite this finding, we detected no significant differences between TRPV1â/â and control mice in the extent of LPS-induced c-Fos expression in numerous fever-related brain subregions. These results suggest that TRPV1 participates in the generation of polyphasic fever, perhaps at sites outside the brain.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 378, Issue 1, 11 April 2005, Pages 28-33
Journal: Neuroscience Letters - Volume 378, Issue 1, 11 April 2005, Pages 28-33
نویسندگان
Tohko Iida, Isao Shimizu, Michele L. Nealen, Ashley Campbell, Michael Caterina,