کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9454702 | 1308542 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Interleukin-1α and tumor necrosis factor α modulate cytochrome P450 activities in carp (Cyprinus carpio)
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کلمات کلیدی
7-ethoxyresorufin-O-deethylaseG6PHEPESPMSFNADPDTTTCDDGSTBAP12-Dimethylbenz[a]anthraceneDMBAα-Naphtoflavone3-methylcholanthreneCYP 1AEROD3-MC - MC-3Benzo[a]pyrene - بنزو [a] پییرنdithiothreitol - دیتیوتریتولcytochrome P450 1a - سیتوکروم P450 1aCytochrome P4501A - سیتوکروم P4501ACytokines - سیتوکین هاModulation - مدولاسیونPolycyclic aromatic hydrocarbons - هیدروکربن آروماتیک چندحلقهایPAHs - هیدروکربن های آروماتیک چند حلقه ایCarp - کپورglutathione-S-transferase - گلوتاتیون S-ترانسفرازglucose-6-phosphate - گلوکز 6-فسفاتaryl hydrocarbon receptor - گیرنده آرویل هیدروکربن
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
شیمی زیست محیطی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
In mammals, it has been shown that the activation of host defense mechanisms down-regulates microsomal cytochrome P450 by the liberation of cytokines. We investigated the effect of interleukin-1α (IL1α) and tumor necrosis factorα (TNFα) on constitutive and 3-methylcholanthrene (3-MC)-induced biotransformation activities in carp. We have first measured the time course response of ethoxyresorufine O-decthylase (EROD) activity in liver, head kidney, and spleen 1, 2, 3, 5, and 7 days after intraperitoneal injection of a prototypical Cyp 1A inducer (3-MC). This activity was compared to the rate of 3-MC accumulation in all organs tested. A correlation between a diminution of EROD activity and an increase in 3-MC concentration in each organ was observed. We have also tested the effects of two inflammatory cytokines (IL1α and TNFα) on biotransformation activities. Intravenous injection of these compounds resulted in a marked depression of 3-MC-induced glutathione S-transferase activity in all organs tested and in 3-MC-increased cytochrome P450 content in the liver and head kidney. TNFα produced an increase in basal EROD activity in the liver and head kidney. Taken together, these results suggested that, as in mammals, the activation of host defense mechanisms regulates microsomal cytochrome P450 and related enzymes in fish.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ecotoxicology and Environmental Safety - Volume 62, Issue 3, November 2005, Pages 355-362
Journal: Ecotoxicology and Environmental Safety - Volume 62, Issue 3, November 2005, Pages 355-362
نویسندگان
S. Reynaud, D. Marrionet, L. Taysse, P. Deschaux,