A new reduction route of hypoxanthine and its nonenzymatic detection based on silver nanoparticles

The interaction between hypoxanthine (HX) and silver nanoparticles (NPs) is studied with electrochemical technique, together with UV-vis spectroscopy (UV-vis) method. A new reduction route of HX corresponding to the transition from carbonyl to carboxyl at C6 of HX is found when HX adsorbs at silver NPs, and a nonenzymatic detection method for HX is constitute based on this new route.