کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9685119 1456223 2005 16 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Chiral resolution of racemic ibuprofen ester in an enzymatic membrane reactor
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی تصفیه و جداسازی
پیش نمایش صفحه اول مقاله
Chiral resolution of racemic ibuprofen ester in an enzymatic membrane reactor
چکیده انگلیسی
In the present study, the production of (S)-ibuprofen acid is reported using lipase-catalyzed hydrolysis reaction in a hollow fiber membrane reactor, as an efficient and cleaner route to obtain single-enantiomer compound. The performance of an enzymatic membrane reactor (EMR) was evaluated by varying operating temperature, organic phase flow rate, aqueous phase flow rate and enzyme loadings. The optimal operating conditions: temperature of 40 °C, pH 8 at EMR residence time (τorg) of 10.87 h (organic inlet flow rate of 80 mL/min) with enzyme loading of 1.78 g/m2 on the spongy layer of membrane were obtained. The kinetic resolution yielded an E value of 13, 31% eeS and 85% eeP. Both substrate and product purity were achieved by recovering the less reactive substrate in the organic stream while enhancing the optical purity of the desired product in the aqueous stream. The EMR system was modeled by incorporating Michaelis-Menten kinetics and treating the system as a continuous flow stirred tank reactor (CSTR). The simulated results agreed well with the experimental data.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Membrane Science - Volume 247, Issues 1–2, 1 February 2005, Pages 185-200
نویسندگان
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