کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9769235 | 1501245 | 2005 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Adrenomedullin: a new target for the design of small molecule modulators with promising pharmacological activities
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
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چکیده انگلیسی
Adrenomedullin (AM) is a 52-amino acid peptide with a pluripotential activity. AM is expressed in many tissues throughout the body, and plays a critical role in several diseases such as cancer, diabetes, cardiovascular and renal disorders, among others. While AM is a protective agent against cardiovascular disorders, it behaves as a stimulating factor in other pathologies such as cancer and diabetes. Therefore, AM is a new and promising target for the development of molecules which, through their ability to regulate AM levels, could be used in the treatment of these pathologies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 40, Issue 8, August 2005, Pages 737-750
Journal: European Journal of Medicinal Chemistry - Volume 40, Issue 8, August 2005, Pages 737-750
نویسندگان
Miguel Julián, Mónica Cacho, Mario A. GarcÃa, Sonsoles MartÃn-SantamarÃa, Beatriz de Pascual-Teresa, Ana Ramos, Alfredo MartÃnez, Frank Cuttitta,