کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9769243 | 1501245 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A solid-phase approach to DDB derivatives
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Since the discovery of 2,2â²-dimethoxycarbonyl-4,4-dimethoxy-5,6,5â²,6â²-biomethylenedioxy-biphenyl (DDB) as a potent anti-HBV agent, we have studied the structure-activity relationships of 4,4â²-dimethoxy-5,6,5â²,6â²-dimethenedioxy-2-alkyloxycarbonyl-2â²-(4-substituted benzyl piperazin-1-yl)carbonyl-biphenyl as anti-HBV agents. Therefore, it is rational to extend this study to the 3,3â²-disustituted-4,4â²-dimethoxy-5,6,5â²,6â²-dimethenedioxy-2-alkyloxycarbonyl-2â²-Serine derivatives. Thus, in an attempt to develop an efficient method for the preparation of a large number of DDB derivatives, the reaction between a DDB acid chloride and serine derivatives on solid support was studied. The structure of resulted compounds was confirmed by LC-MS and 1H NMR analysis. Compounds 2a, 2d, 2f, 2j showed in vitro anti-HBV activity without significant toxicity up to 100 μM.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 40, Issue 8, August 2005, Pages 805-810
Journal: European Journal of Medicinal Chemistry - Volume 40, Issue 8, August 2005, Pages 805-810
نویسندگان
Xiuxiang Qi, Xiaolai Wang, Limin Wang, Qiang Wang, Senxiang Cheng, Jishuan Suo, Junbiao Chang,