کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9774647 | 1509091 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The use of thiolated polymers as carrier matrix in oral peptide delivery-Proof of concept
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی مواد
بیومتریال
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Results showed stability of antide towards pepsin, trypsin and chymotrypsin. In contrast, antide was rapidly degraded by elastase. Consequently a stomach-targeted delivery system was designed. Drug release studies demonstrated an almost zero-order controlled release of antide over 8 h. In vivo studies demonstrated a relative bioavailability of 34.4% for the subcutaneous administration. Oral administration of antide in solution led to no detectable concentrations of the drug in plasma at all. In contrast, administering antide being incorporated in the thiolated polymer resulted in a significant uptake of the peptide. The absolute and relative bioavailability was determined to be 1.1% and 3.2%, respectively.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Controlled Release - Volume 106, Issues 1â2, 18 August 2005, Pages 26-33
Journal: Journal of Controlled Release - Volume 106, Issues 1â2, 18 August 2005, Pages 26-33
نویسندگان
Andreas Bernkop-Schnürch, Yvonne Pinter, Davide Guggi, Hermann Kahlbacher, Gudrun Schöffmann, Maximilian Schuh, Ivo Schmerold, Maria Dorly Del Curto, Mauro D'Antonio, Pierandrea Esposito, Christian Huck,