A Gβγ inhibitor reduces intimal hyperplasia in aortocoronary saphenous vein grafts

This study demonstrates that βARKct expression in aortocoronary saphenous vein grafts reduces intimal hyperplasia and decreases vascular smooth muscle cell proliferation in vitro via inhibition of Gβγ-mediated mitogen-activated protein kinase activation. Modulation of Gβγ via βARKct may represent a novel therapy to reduce intimal hyperplasia and saphenous vein graft failure.