Keywords: 5-HT، 5-hydroxytryptamine; Autism spectrum disorders; Retinoic acid; Chinese; Severity; Risk; Rar; retinoic acid receptor; Rxr; retinoid x receptor; Asd; autism spectrum disorder; Bmi; body mass index; Cars; childhood autism rating scale; Elisa; enzyme-linked immunosorbent assay; C
مقالات ISI 5-HT، 5-hydroxytryptamine (ترجمه نشده)
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Keywords: 5-HT، 5-hydroxytryptamine; 4EPS, 4-ethylphenylsulfate; 5-HT, 5-hydroxytryptamine; AA, acetic acid; ANS, autonomic nervous system; ASD, autism spectrum disorder; BBB, blood–brain barrier; CHD8, chromodomain helicase DNA-binding protein 8; CNS, central nervous system; CRH, corticotro
Keywords: 5-HT، 5-hydroxytryptamine; 5CSRT, 5 Choice Serial Reaction Time Task; 5-HT, 5-hydroxytryptamine; AMPA, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; Amph, amphetamine; ANOVA, analysis of variance; BD, bipolar disorder; CBZ, carbamazepine; D, dopamine receptor; DA, dopamine
Keywords: 5-HT، 5-hydroxytryptamine; 5-HT, 5-hydroxytryptamine; AC, adenylyl cyclase; ADHD, attention deficit hyperactivity disorder; AMPA, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; cAMP, 3′,5′-cyclic adenosine monophosphate; DA, dopamine; DAT, dopamine transporter; dlPFC, dorsol
Keywords: 5-HT، 5-hydroxytryptamine; 5-HT, 5-hydroxytryptamine; NO, nitric oxide; NOS, nitric oxide synthase; iNOS, inducible nitric oxide synthase; nNOS, neuronal nitric oxide synthase; cGMP, cyclic guanosine monophosphate; FST, forced swimming test; TST, tail suspension test; OFT, open-fie
Keywords: 5-HT، 5-hydroxytryptamine; 5-HIAA, 5-hydroxyindoleacetic acid; 5-HT, 5-hydroxytryptamine; BBB, blood brain barrier; BDNF, brain-derived neurotrophic factor; CMC, carboxy-methyl-cellulose; CNS, Central nervous system; Con, control; DA, dopamine; DAT, dopamine transporter; DOPAC, 3,4
Keywords: 5-HT، 5-hydroxytryptamine; Monoamine transporter; Uptake; Surface expression; Kinase; siRNA screen; PrKXDAT, dopamine transporter; SERT, serotonin transporter; NET, norepinephrine transporter; DA, dopamine; 5-HT, 5-hydroxytryptamine; NE, norepinephrine; siRNA, small interfering RNA
Keywords: 5-HT، 5-hydroxytryptamine; 5-CSRTT, 5-choice serial reaction time task; 5-HT, 5-hydroxytryptamine; ADHD, attention-deficit/hyperactivity disorder; ASR, acoustic startle response; BL, baseline; DOI, 2,5-dimethoxy-4-iodoamphetamine; HI, high impulsive; HR, high reward; ISI, interstim
Keywords: 5-HT، 5-hydroxytryptamine; DA, dopamine; SPE, solid phase extraction; SBSE, stir bar sorptive extraction; MIP-SB, molecularly imprinted polymer coated stir bar; PDMS, polydimethysiloxane; E, l-epinephrin; NE, l-norepinephrine; 5-HT, 5-hydroxytryptamine; EGDMA, ethylene glycol dimet
Keywords: 5-HT، 5-hydroxytryptamine; 5-HT, 5-hydroxytryptamine; PBS, phosphate-buffered saline; PEX, peroxisome biogenesis; SEM, standard error of the mean; TPH2, tryptophan hydroxylase-2; ZS, Zellweger syndromeZellweger syndrome; PEX13 brain mutant; raphe nuclei; serotonin; gliosis; apoptos
Keywords: 5-HT، 5-hydroxytryptamine; 5-HW, 5-hydroxytryptophan; 5-HT, 5-hydroxytryptamine; TDC, tryptophan decarboxylaseHPLC−fluorescence detection; Serotonin; Tryptamine; Tryptophan
Keywords: 5-HT، 5-hydroxytryptamine; 5-HT, 5-hydroxytryptamine; AD, Alzheimer's disease; ANOVA, analysis of variance; DMSO, dimethylsulfoxide; FST, forced-swim test; i.c.v., intracerebroventicular; i.p., intraperitoneal; LPS, lipopolysaccharide; MAPKs, mitogen-activated protein kinases; s.c.
Activation of islet 5-HT4 receptor regulates glycemic control through promoting insulin secretion
Keywords: 5-HT، 5-hydroxytryptamine; 5-HT, 5-hydroxytryptamine; INS, insulin; GLU, glucagon; PP, pancreatic polypeptide; SST, somatostatinMosapride citrate (PubChem CID: 119583); Prucalopride succinate (PubChem CID: 9870009); GR113808 (PubChem CID: 119376)5-HT4 receptor; Mosapride; Prucalopr
Serum metabonomics study of anti-depressive effect of Xiao-Chai-Hu-Tang on rat model of chronic unpredictable mild stress
Keywords: 5-HT، 5-hydroxytryptamine; XCHT, Xiao-Chai-Hu-Tang; CUMS, chronic unpredictable mild stress; UPLC, ultra performance liquid chromatography; QC, quality control; RT, retention time; RSD, relative standard deviations; RE, relative errors; 5-HT, 5-hydroxytryptamine; ROS, active oxygen
5-HT2 receptor blockade exhibits 5-HT vasodilator effects via nitric oxide, prostacyclin and ATP-sensitive potassium channels in rat renal vasculature
Keywords: 5-HT، 5-hydroxytryptamine; 1-PBG, 1-phenylbiguanide; 5-CT, 5-carboxamidotryptamine; 5-HT, 5-hydroxytryptamine; 8-OH-DPAT, 8-hydroxy-2-dipropylaminotetralin hydrobromide; AS-19, (2S)(+)-5-(1,3,5-trimethylpyrazol-4-yl)-2-(dimethylamino)tetralin; BSA, bovine serum albumin; CGS-12066B,
Estimation of excitatory and inhibitory synaptic conductance variations in motoneurons during locomotor-like rhythmic activity
Keywords: 5-HT، 5-hydroxytryptamine; 5-HT, 5-hydroxytryptamine; ACF, autocorrelation function; CNS, central nervous system; CPG, central pattern generator; MN, motoneuron; NMDA, N-methyl-d-aspartate; VR, ventral rootsynaptic conductance estimation; locomotion; spinal cord; central pattern ge
Evaluation of the anti-inflammatory effects of volatile oils from processed products of Angelica sinensis radix by GC–MS-based metabolomics
Keywords: 5-HT، 5-hydroxytryptamine; AS, roots of Angelica sinensis (Oliv.) Diels; TCM, traditional Chinese medicine; VOAS, the volatile oil of AS; HIS, histamine; 5-HT, 5-hydroxytryptamine; TNF-α, tumor necrosis factor-alpha; MSTFA, N-Methy-N-(trimethylsilyl) trifluoroacetamide; TMCS, trime
Current drug treatments targeting dopamine D3 receptor
Keywords: 5-HT، 5-hydroxytryptamine; 5-HT, 5-hydroxytryptamine; 7-OH-DPAT, 7-hydroxy-N,N-di-n-propyl-2-aminotetralin; [11C]-(+)-PHNO, [11C]-(+)-propyl-hexahydro-naphtho-oxazin; AH, aqueous humor; BDNF, Brain-Derived Neurotrophic Factor; CNS, central nervous system; DA, dopamine; DR, dopamine
Ergotamine and nicergoline – Facts and myths
Keywords: 5-HT، 5-hydroxytryptamine; GPCR, G-protein coupled receptors; D, dopamine; EMEA, European Medicines Agency; ERK, extracellular signal-regulated kinase; 5-HT, 5-hydroxytryptamine; VHD, valvular heart diseaseNicergoline; Ergotamine; Valvunopathy; 5-HT2B agonism; Biased signaling
In vivo study on the neurotransmitters and their metabolites change in depressive disorder rat plasma by ultra high performance liquid chromatography coupled to tandem mass spectrometry
Keywords: 5-HT، 5-hydroxytryptamine; 5-HT, 5-hydroxytryptamine; 5-HIAA, 5-hydroxyindoleacetic acid; DA, dopamine; NE, norepinephrine; HVA, homovanillic acid; GABA, γ-aminobutyric acid; Glu, glutamic acid; ESI, electrospray ionization; UHPLC, ultra-high performance liquid chromatography; LLOQ
Mice lacking integrin β3 expression exhibit altered response to chronic stress
Keywords: 5-HT، 5-hydroxytryptamine; Integrin; ITGB3; Chronic stress; Depression; Glutamate; Serotonin5-HIAA, 5-Hydroxyindoleacetic acid; 5-HT, 5-hydroxytryptamine; AMPA, α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; ANOVA, analysis of variance; A.U., arbitrary units; BSA, bovine ser
Activation of serotonin 5-HT7 receptor induces coronary flow increase in isolated rat heart
Keywords: 5-HT، 5-hydroxytryptamine; 5-HT, 5-hydroxytryptamine; NO, nitric oxide; NOS, nitric oxide synthase; l-NAME, Nω-Nitro-l-arginine methyl ester hydrochlorideSerotonin; 5-HT7; 5-HT2A; Coronary flow; Nitric oxide
H2S induces vasoconstriction of rat cerebral arteries via cAMP/adenylyl cyclase pathway
Keywords: 5-HT، 5-hydroxytryptamine; 5-HT, 5-hydroxytryptamine; 8B-cAMP, 8-bromoadenosine-3′, 5′-cyclic monophosphate; BayK, Bay K-8644; DMSO, dimethyl sulfoxide; EC50, the concentration that produce 50% of the maximal constriction; Emax, maximal constriction; Forsk, forskolin; H2S, hydrogen
Alteration of enteric monoamines with monoamine receptors and colonic dysmotility in 6-hydroxydopamine–induced Parkinson's disease rats
Keywords: 5-HT، 5-hydroxytryptamine; β-AR, β-adrenoceptor; DA, dopamine; DAT, dopamine transporter; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; GI, gastrointestinal; 5-HT, 5-hydroxytryptamine; IR, immunoreactive; NE, norepinephrine; 6-OHDA, 6-hydroxydopamine; PD, Parkinson's disease; SN
SLC6A4 markers modulate platelet 5-HT level and specific behaviors of autism: A study from an Indian population
Keywords: 5-HT، 5-hydroxytryptamine; SLC6A4, Solute carrier family 6 (Neurotransmitter Transporter), Member 4; 5-HT, 5-hydroxytryptamine; 5-HTTLPR, 5-HT transporter linked polymorphic region; VNTR, variable number tandem repeats; SNP, single nucleotide polymorphism; UTR, untranslated regionC
Berberine is a dopamine D1- and D2-like receptor antagonist and ameliorates experimentally induced colitis by suppressing innate and adaptive immune responses
Keywords: 5-HT، 5-hydroxytryptamine; IBD, inflammatory bowel diseases; UC, ulcerative colitis; CD, Crohn's disease; IFN-γ, interferon gamma; IL-17, interleukin-17; Th1, T-helper 1; Th2, T-helper 2; Th17, T-helper 17; 5-HT, 5-hydroxytryptamine; DCs, dendritic cells; DSS, dextran sodium salt;
Nigella sativa L. seeds modulate mood, anxiety and cognition in healthy adolescent males
Keywords: 5-HT، 5-hydroxytryptamine; NS, Nigella sativa L. seeds; CVLT-II, modified California verbal learning test-II; STAI, State–Trait Anxiety Inventory; ADHD, attention deficit hyperactivity disorder; CONSORT, consolidated standards of reporting trials; 5-HT, 5-hydroxytryptamine; GABA, g
Anti-inflammatory effects of 5-HT3 receptor antagonists in interleukin-1beta stimulated primary human chondrocytes
Keywords: 5-HT، 5-hydroxytryptamine; 5-HT, 5-hydroxytryptamine; IL, interleukin; PG, prostaglandin; COX, cyclooxygenase; mPGES, microsomal prostaglandin E synthaseTropisetron; Serotonin; Prostaglandin E2; Cytokines; Cyclooxygenase; Chondrocytes
Dynamic changes in dopamine neuron function after DNSP-11 treatment: Effects in vivo and increased ERK 1/2 phosphorylation in vitro
Keywords: 5-HT، 5-hydroxytryptamine; Dopamine; Glial cell line-derived neurotrophic factor; Parkinson's disease; Striatum; PeptideDOPAC, 3,4-dihydroxyphenylacetic acid; 5-HT, 5-hydroxytryptamine; 5-HIAA, 5-hydroxyindoleacetic acid; DA, dopamine; DNSP-11, dopamine neuron stimulating peptide-1
Isorhynchophylline improves learning and memory impairments induced by D-galactose in mice
Keywords: 5-HT، 5-hydroxytryptamine; 5-HT, 5-hydroxytryptamine; Aβ25–35, beta-amyloid; CAT, catalase; COX-2, cyclooxygenase-2; D-gal, D-galactose; EDTA, ethylenediaminetetraacetic acid; GSH, glutathione; GPx, glutathione peroxidase; GSK-3β, glycogen synthase kinase 3 beta; IκB-α, IkappaB alp
Role of 5-HT7 receptors in the inhibition of the vasodepressor sensory CGRPergic outflow in pithed rats
Keywords: 5-HT، 5-hydroxytryptamine; CGRP, Calcitonin gene-related peptide; DBP, Diastolic blood pressure; D-R curves, Dose–response curves; ECE-1, Endothelin-converting enzyme-1; Glibencl, Glibenclamide; HR, Heart rate; 5-HT, 5-Hydroxytryptamine; Indometh, Indomethacin; i.v ., Intravenous;
Cell permeable peptide conjugated nanoerythrosomes of fasudil prolong pulmonary arterial vasodilation in PAH rats
Keywords: 5-HT، 5-hydroxytryptamine; Targeted delivery; Rho-kinase; Fasudil; Nanoerythrosomes; Controlled release; Pulmonary arterial hypertension; Pulmonary delivery; SafetyALP, alkaline phosphatase; BAL, bronchoalveolar lavage; CAR, CARSKNKDC; 5-HT, 5-hydroxytryptamine; LDH, lactate dehydr
Pharmacological benefit of I1-imidazoline receptors activation and nuclear factor kappa-B (NF-κB) modulation in experimental Huntington's disease
Keywords: 5-HT، 5-hydroxytryptamine; 3-NPA, 3-nitropropionic acid; 5-HT, 5-hydroxytryptamine; ACh, acetylcholine; AChE, acetylcholinesterase; BDNF, brain derived neurotrophic factor; BSA, bovine serum albumin; BW, body weight; CAG, cytosine adenine guanine; cAMP, cyclic adenosine monoamine p
Crosstalk between 5-HT2cR and PTEN signaling pathway in atypical antipsychotic-induced metabolic syndrome and cognitive dysfunction
Keywords: 5-HT، 5-hydroxytryptamine; TAPs, typical antipsychotics; EPS, extrapyramidal syndromes; AAPs, atypical antipsychotics; FDA, US Food and Drug Administration; 5-HT, 5-hydroxytryptamine; MetS, metabolic syndrome; CATIE, Clinical Antipsychotic Trials of Intervention Effectiveness; NCEP
Rikkunshito and isoliquiritigenin counteract 5-HT-induced 2C receptor-mediated activation of pro-opiomelanocortin neurons in the hypothalamic arcuate nucleus
Keywords: 5-HT، 5-hydroxytryptamine; 5-HT, 5-hydroxytryptamine; POMC, pro-opiomelanocortin; ARC, hypothalamic arcuate nucleus; SSRIs, selective serotonin reuptake inhibitors; PVN, paraventricular nucleus; CRH, corticotrophin-releasing hormoneAnorexia; Rikkunshito; 5-Hydroxytryptamine; 5-HT2C
Binding of lurasidone, a novel antipsychotic, to rat 5-HT7 receptor: Analysis by [3H]SB-269970 autoradiography
Keywords: 5-HT، 5-hydroxytryptamine; 5-HT, 5-hydroxytryptamine; CHO, Chinese hamster ovary5-HT7 receptors; Autoradiography; [3H]SB-269970; Lurasidone; Antipsychotic; Rat
Safety and Efficacy of Cyproheptadine for Treating Dyspeptic Symptoms in Children
Keywords: 5-HT، 5-hydroxytryptamine; 5-HT, 5-hydroxytryptamine; ADM, Antroduodenal manometry; FD, Functional dyspepsia; GES, Gastric emptying study
Association between 5-HT2A receptor polymorphisms and risk of obstructive sleep apnea and hypopnea syndrome: A systematic review and meta-analysis
Keywords: 5-HT، 5-hydroxytryptamine; OSAHS, obstructive sleep apnea and hypopnea syndrome; 5-HT, 5-hydroxytryptamine; AHI, apnea–hypopnea index; BMI, body mass index; HWE, Hardy–Weinberg equilibrium; OR, odds ratio; CI, confidence intervalObstructive sleep apnea and hypopnea syndrome; 5-Hydr
Results of the Tokyo Trial of Prevention of Post-ERCP Pancreatitis with Risperidone-2: a multicenter, randomized, placebo-controlled, double-blind clinical trial
Keywords: 5-HT، 5-hydroxytryptamine; 5-HT, 5-hydroxytryptamine; p-amylase, pancreatic amylase; PEP, post-ERCP pancreatitis
The Receptor TGR5 Mediates the Prokinetic Actions of Intestinal Bile Acids and Is Required for Normal Defecation in Mice
Keywords: 5-HT، 5-hydroxytryptamine; Digestion; Mouse Model; Intestine; DiarrheaBA, bile acid; BDNF, brain-derived neurotropic factor; CGRP, calcitonin gene-related peptide; DCA, deoxycholic acid; EC, enterochromaffin; 5-HT, 5-hydroxytryptamine; IPAN, intrinsic primary afferent neuron; IR, i
Cannabinoid agonists increase the interaction between β-Arrestin 2 and ERK1/2 and upregulate β-Arrestin 2 and 5-HT2A receptors
Keywords: 5-HT، 5-hydroxytryptamine; 5-HT, 5-hydroxytryptamine; 5-HT2A, serotonin 2A; Δ9-THC, Δ9-tetrahydrocannabinol; ERK, extracellular regulated kinase; PFCx, prefrontal cortex; GPCR, G-protein coupled receptor; MAP, mitogen activated protein kinase; pERK, phosphorylated extracellular reg
Peripheral and spinal 5-HT receptors participate in the pronociceptive and antinociceptive effects of fluoxetine in rats
Keywords: 5-HT، 5-hydroxytryptamine; ANOVA, one-way analysis of variance; AUC, area under the number of flinches against time curves; 5-HT, 5-hydroxytryptamine; BRL-15572, 4-(3-chlorophenyl)-α-(diphenylmethyl)-1-piperazineethanol hydrochloride; DRG, dorsal root ganglion; GR-113808, [1-[2-met
Simultaneous determination of tyrosine, tryptophan and 5-hydroxytryptamine in serum of MDD patients by high performance liquid chromatography with fluorescence detection
Keywords: 5-HT، 5-hydroxytryptamine; HPLC-FLD, high performance liquid chromatography with fluorescence detection; Tyr, tyrosine; Trp, tryptophan; 5-HT, 5-hydroxytryptamine; MDD, major depressive disorderHigh performance liquid chromatography; Fluorescence detection; Tyrosine; Tryptophan; 5-
The anti-inflammatory effects of the 5-HT3 receptor antagonist tropisetron are mediated by the inhibition of p38 MAPK activation in primary human monocytes
Keywords: 5-HT، 5-hydroxytryptamine; 5-HT, 5-Hydroxytryptamine; IL, interleukin; TNF, tumor necrosis factor; PG, prostaglandin; MMP, matrix metalloprotease; PMA, phorbol myristate acetate; PHA, phytohemagglutinin; LPS, lipopolysaccharide; MAPK, mitogen-activated protein kinaseTropisetron; Se
Increased expression of tryptophan-5-hydroxylase 1, but not 2, in brainstem as a result of intrauterine malnutrition
Keywords: 5-HT، 5-hydroxytryptamine; IUM, intrauterine malnutrition; TPH, tryptophan-5-hydroxylase; 5-HT, 5-hydroxytryptamine; CNS, central nervous system; BH4, tetrahydrobiopterin; l-Trp, l-tryptophan; FLT, free fraction of l-Trp; BBB, blood–brain barrier; cAMP, cyclic adenosine monophospha
The simultaneous presence of neuroepithelial cells and neuroepithelial bodies in the respiratory gas bladder of the longnose gar, Lepisosteus osseus, and the spotted gar, L. oculatus
Keywords: 5-HT، 5-hydroxytryptamine; ChAT, choline acetyltransferase; 5-HT, 5-hydroxytryptamine; NEBs, neuroepithelial bodies; NECs, neuroepithelial cells; PACAP, pituitary adenylate cyclase-activating polypeptide; RE, respiratory epithelium; SM, striated muscle; SP, substance P; TH, tyrosin
Estrogenic effects and their action mechanism of the major active components of party pill drugs
Keywords: 5-HT، 5-hydroxytryptamine; 5-HT, 5-hydroxytryptamine; ATCC, American type culture collection; BZP, benzylpiperazine; CD, charcoal-dextran; DMEM, Dulbecco's modified Eagles medium; E2, estradiol; EEFs, estradiol equivalency factors; ER, estrogen receptor; ERE, estrogen receptor elem
Increased Reissner's fiber material in the subcommissural organ and ventricular area in bile duct ligated rats
Keywords: 5-HT، 5-hydroxytryptamine; BDL, bile duct ligation; CSF, cerebrospinal fluid; CVO, circumventricular organs; DRN, dorsal raphe nucleus; HE, hepatic encephalopathy; 5-HT, 5-hydroxytryptamine; RF, Reissner's fiber; SCO, subcommissural organSubcommissural organ; Serotonin; Reissner's
The opposite effect of a 5-HT1B receptor agonist on 5-HT synthesis, as well as its resistant counterpart, in an animal model of depression
Keywords: 5-HT، 5-hydroxytryptamine; FSL, Flinders Sensitive Line; FRL, Flinders Resistant Line; 5-HT, 5-hydroxytryptamine; α-MTrp, α-methyl-l-tryptophan; CP-94253, 5-propoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-pyrrolo [3,2-b]pyridine hydrochloride; DFP, diisopropyl fluorophosphatesFlinder
Isorhynchophylline: A plant alkaloid with therapeutic potential for cardiovascular and central nervous system diseases
Keywords: 5-HT، 5-hydroxytryptamine; 5-HT, 5-hydroxytryptamine; DDP, cisplatin; IC50, 50% inhibitory concentration; NMDA, N-methyl-d-aspartateIsorhynchophylline; Antihypertensive; Antiarrhythmia; Neuroprotective; Sedation