Keywords: Dopamine; Serotonin; Obesity; Neuroimaging; Humans; 5-HT1A,B; serotonin 1A and 1B receptor; 5-HT2A; serotonin 2A receptor; 5-HT2C; serotonin 2C receptor; 5-HT4; serotonin 4 receptor; Bmax; receptor or transporter availability; BMI; body mass index; BP; bi
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Keywords: Genetics; Obsessive-compulsive disorder; OCD; Serotonin system; Neuropsychiatry; Neuroscience; Psychiatry; Candidate gene; Genetic association; Serotonin transporter; SLC6A4; 5-HTTLPR; HTR2A; 5-HT2A; HTR1B; 5-HT1B; HTR2C; 5-HT2C; Subtypes; Symptom dimensi
Keywords: DRN; dorsal raphe nucleus; ES; escapable tailshock; IS; Inescapable tailshock; 5-HT; 5-hydroxytryptamine; ANOVA; analysis of variance; LSD; least significant difference; SEM; standard error of the mean; HC; home cage; 5-HT2C; Anxiety; Learned helplessness
Keywords: Serotonin; Stress; Social evaluation; 5-HT2C; 5-HTTLPR; Cortisol
Serotonin 2C receptor antagonist improves fear discrimination and subsequent safety signal recall
Keywords: 5-HT2C; Rat; Anxiety; Stress; Fear; Conditioned inhibition;
Heart rate variability in major depressive disorder and after antidepressant treatment with agomelatine and paroxetine: Findings from the Taiwan Study of Depression and Anxiety (TAISDA)
Keywords: ANOVA; Analysis of variance; BMI; Body mass index; BDI; Beck Depression Inventory; BAI; Beck Anxiety Inventory; CVD; Cardiovascular disease; DBP; Diastolic blood pressure; HRV; Heart rate variability; HAM-D; Hamilton Depression Rating Scale; HAM-A; Hamilt
Rat exposure in mice with neuropathic pain induces fear and antinociception that is not reversed by 5-HT2C receptor activation in the dorsal periaqueductal gray
Keywords: 5-HT2C; Antinociception; Anxiety; Chronic constriction injury; Periaqueductal gray; Rat exposure test
Expression of hippocampal serotonin receptors 5-HT2C and 5-HT5A in a rat model of diet-induced obesity supplemented with tryptophan
Keywords: 5-HT2C; 5-HT5A; High energy diet; Hippocampus; Obesity
Decreased serotonin2C receptor responses in male patients with schizophrenia
Keywords: Serotonin; 5-HT2C; MK-212; Schizophrenia; Temperature; Anxiety;
Synthesis and biological evaluation of 4-nitroindole derivatives as 5-HT2A receptor antagonists
Keywords: 4-Nitroindole; Sulfonamides; Methyleneamino-N,N-dimethylformamidine group; 5-HT2A; 5-HT2C; 5-HT6 receptor
Nucleus accumbens shell excitability is decreased by methamphetamine self-administration and increased by 5-HT2C receptor inverse agonism and agonism
Keywords: Methamphetamine; Serotonin; Nucleus accumbens; Constitutive activity; Inverse agonist; 5-HT2C;
Looking for prosocial genes: ITRAQ analysis of proteins involved in MDMA-induced sociability in mice
Keywords: 5-HT1A; serotonin receptor subtype 1a; 5-HT2C; serotonin receptor subtype 2c; FDR; false discovery rate; GHB; gamma-hydroxybutyrate; GPCR; G-protein coupled receptor; iTRAQ; isobaric tag for relative and absolute quantification; LC; liquid chromatography;
Postnatal Fluoxetine-Evoked Anxiety Is Prevented by Concomitant 5-HT2A/C Receptor Blockade and Mimicked by Postnatal 5-HT2A/C Receptor Stimulation
Keywords: Antidepressant; DOI; 5-HT1A; 5-HT2A; 5-HT2C; ketanserin; Prozac; SSRI; WAY-100635
Characterization of [11C]Cimbi-36 as an agonist PET radioligand for the 5-HT2A and 5-HT2C receptors in the nonhuman primate brain
Keywords: 5-HT2A; 5-HT2C; [11C]Cimbi-36; Agonist; Monkey; Serotonin receptors;
Rikkunshito and isoliquiritigenin counteract 5-HT-induced 2C receptor-mediated activation of pro-opiomelanocortin neurons in the hypothalamic arcuate nucleus
Keywords: 5-HT, 5-hydroxytryptamine; POMC, pro-opiomelanocortin; ARC, hypothalamic arcuate nucleus; SSRIs, selective serotonin reuptake inhibitors; PVN, paraventricular nucleus; CRH, corticotrophin-releasing hormoneAnorexia; Rikkunshito; 5-Hydroxytryptamine; 5-HT2C
Antagonizing 5-HT2A receptors with M100907 and stimulating 5-HT2C receptors with Ro60-0175 blocks cocaine-induced locomotion and zif268 mRNA expression in Sprague-Dawley rats
Keywords: Serotonin; Cocaine; Zif; 5-HT2A; 5-HT2C; Locomotor
The N-terminal region of the human 5-HT2C receptor has as a cleavable signal peptide
Keywords: 5-HT2C; Signal peptide; Receptor construct; Cys23Ser; C23S; N-tail; rs6318;
Developmental alterations in CNS stress-related gene expression following postnatal immune activation
Keywords: 5-HT; serotonin; 5-HT2A; serotonin receptor 2A; 5-HT2C; serotonin receptor 2C; ACTH; adrenocorticotropic releasing hormone; BLA; basolateral amygdala; CA1; cornuammonis 1; CA3; cornuammonis 3; CeA; central amygdala; CNS; central nervous system; CORT; cort
Effects of the 5-HT2C receptor agonist Ro60-0175 and the 5-HT2A receptor antagonist M100907 on nicotine self-administration and reinstatement
Keywords: Nicotine; Self-administration; Reinstatement; Serotonin; 5-HT2A; 5-HT2C
Differential involvement of dorsal raphe subnuclei in the regulation of anxiety- and panic-related defensive behaviors
Keywords: 5-HT1A; serotonin-1A receptor; 5-HT2C; serotonin-2C receptor; ANOVA; analysis of variance; BLA; basolateral amygdala; CO2; carbondioxide; CRF; corticotrophin-releasing factor; DH; dorsal hippocampus; dlPAG; dorsolateral column of the periaqueductal gray m
Design, synthesis and pharmacological evaluation of new series of naphthalenic analogues as melatoninergic (MT1/MT2) and serotoninergic 5-HT2C dual ligands (I)
Keywords: Agomelatine; Agonist; Antagonist; Depression; 5-HT2C; MT1; MT2MLT, melatonin; MT1, melatonin receptor subtype 1; MT2, melatonin receptor subtype 2; 5-HT2C, serotonin receptor subtype 2C; [35S]GTPγS, [35S]guanosine-5′-O-(3-thio-triphosphate)
Mirtazapine antagonises the subjective, hormonal and neuronal effects of m-chlorophenylpiperazine (mCPP) infusion: A pharmacological-challenge fMRI (phMRI) study
Keywords: m-Chlorophenylpiperazine (mCPP); 5-HT2c; Pharmacological-challenge fMRI (phMRI); Mirtazapine; Cortisol; Subjective effects;
Serotonergic involvement in methamphetamine-induced locomotor activity: A detailed pharmacological study
Keywords: Methamphetamine; Serotonin receptors; Dopamine receptors; 5-HT2A; 5-HT2C; 5-HT1B; D1; D2;
Synthesis and biological activity of 5-styryl and 5-phenethyl-substituted 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indoles
Keywords: Pyridoindoles; Dimebolin; Dimebon; Receptor; Serotonergic; 5-HT7; 5-HT6; 5-HT2C; Adrenergic; Alpha 2; Histamineergic; H1; Calcium mobilization
Tricyclic dihydroquinazolinones as novel 5-HT2C selective and orally efficacious anti-obesity agents
Keywords: Serotonin; 5-HT2C; Obesity
5-Hydroxytryptamine 2C Receptors in the Basolateral Amygdala Are Involved in the Expression of Anxiety After Uncontrollable Traumatic Stress
Keywords: 5-HT2c; learned helplessness; PTSD; rat; serotonin; social exploration;
Synthesis and structure–affinity relationships of novel small molecule natural product derivatives capable of discriminating between serotonin 5-HT1A, 5-HT2A, 5-HT2C receptor subtypes
Keywords: 5-HT, 5-hydroxytryptamine (serotonin); 5-HT1A, serotonin receptor subtype 1A; 5-HT2A, serotonin receptor subtype 2A; 5-HT2C, serotonin receptor subtype 2C5-HT2C receptor selective ligand; 5-HT2C; Serotonin receptor; 5-Hydroxytryptamine; Natural product an
Design and synthesis of pyridazinone-based 5-HT2C agonists
Keywords: 5-HT2C; Agonist; Pyridazinone; CNS penetration
Design and synthesis of piperazinylpyrimidinones as novel selective 5-HT2C agonists
Keywords: 5-HT2C; Agonist; Pyrimidinone; CNS penetration
Selective Serotonin Reuptake Inhibitors Modify Physiological Gastrointestinal Motor Activities via 5-HT2c Receptor and Acyl Ghrelin
Keywords: 5-HT2c; gastrointestinal motility; ghrelin; melanocortin; SSRIs
The 5-HT2C receptor agonist WAY-163909 decreases impulsivity in the 5-choice serial reaction time test
Keywords: 5-HT2C; Impulsivity; 5-Choice serial reaction time test
2-Alkyl-4-aryl-pyrimidine fused heterocycles as selective 5-HT2A antagonists
Keywords: Serotonin; 5-HT2A; 5-HT2B; 5-HT2C; 5-HT
The influence of 5-HT2C and MDR1 genetic polymorphisms on antipsychotic-induced weight gain in female schizophrenic patients
Keywords: Schizophrenia; Olanzapine; Risperidone; Genetic polymorphism; 5-HT2C; MDR1; Weight gain
Serotonergic approaches in the development of novel antipsychotics
Keywords: Schizophrenia; Serotonin; 5-HT1A; 5-HT2C; 5-HT6; 5-HT7; SSRI; Antipsychotic; D28-OH-DPAT, 8-hydroxy-2-(di-N-propylamino)-tetralin; 5-HT, 5-hydroxytryptamine, serotonin; 5-HTP, 5-hydroxytryptophan; ACh, acetylcholine; CAR, conditioned avoidance response; D
Genetic variation in cortico-amygdala serotonin function and risk for stress-related disease
Keywords: Stress; Gene; Strain; Mouse; Inbred; Serotonin; Serotonin transporter; Tryptophan hydroxylase; VMAT2; MAOA; 5-HT1A; 5-HT1B; 5-HT2A; 5-HT2C; 5-HT3; Prefrontal cortex; Hippocampus; Amygdala; Anxiety; Depression; Emergence test; Forced swim test; Restraint
Increased 5-HT2C receptor binding in the brain stem and cerebral cortex during liver regeneration and hepatic neoplasia in rats
Keywords: 5-HT2C; Brain stem; Cerebral cortex; Liver regeneration; Hepatic neoplasia; Partial hepatectomy;
The identification of pyrimidine-diazabicyclo[3.3.0]octane derivatives as 5-HT2C receptor agonists
Keywords: 5-HT2C; Obesity
Pyrrolo(iso)quinoline derivatives as 5-HT2C receptor agonists
Keywords: Obesity; Serotonin; 5-HT2C; Agonist
The design and synthesis of a tricyclic single-nitrogen scaffold that serves as a 5-HT2C receptor agonist
Keywords: Obesity; 5-HT2C; GPCR
Diaryl substituted pyrrolidinones and pyrrolones as 5-HT2C inhibitors: Synthesis and biological evaluation
Keywords: Serotonin; 5-HT; 5-HT2C; 7-TM; Pharmacophore
Discovery and SAR of new benzazepines as potent and selective 5-HT2C receptor agonists for the treatment of obesity
Keywords: 5-HT2C; Serotonin; Obesity; Benzazepine;
Membrane phospholipid composition, alterations in neurotransmitter systems and schizophrenia
Keywords: AA; arachidonic acid; Acb; nucleus accumbens; ACC; anterior cingulate cortex; ADP; adenosine diphosphate; Amg; amygdala; BPRS; brief psychiatric rating score; CA1-3; CA1-3 fields of the hippocampus; CHO; carbohydrate; CPRS; comprehensive psychiatric r