Keywords: MÏCM; conditioned medium of macrophages; PMA; phorbol 12-myristate 13-acetate; MTT; 3-(4,5-dimethyl-thiazol-2-yl) 2,5-diphenyl-tetrazolium bromide; qRT-PCR; quantitative real-time polymerase chain reaction; TAM; tumor associated macrophage; DMSO; dimethy
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Glyceollins: Soybean phytoalexins that exhibit a wide range of health-promoting effects
Keywords: 3T3-L1; mouse fibroblast cell line; 4CL; 4-coumarate:coenzyme A ligase; ABTS; 2,2â²-azinobis(3-ethylbenzthiazoline-6-sulfonate); ACC; acetyl-coA carboxylase; AKT; protein kinase B; AMPK; adenosine-monophosphate kinase; Ang-1; angiopoietin-1; BCRP; breast
Keywords: High-fat; Non-alcoholic liver disease; Obesity; Scopoletin; Transcriptome; ALT; alanine aminotransferase; Apoa4; apolipoprotein A-IV; AST; aspartate aminotransferase; β-oxidation; fatty acid β-oxidation; Cdkn1a; cyclin-dependent kinase inhibitor 1A; Cid
Keywords: A-bomb; atomic bomb; ATM; ataxia telangiectasia mutated; ATP; adenosine triphosphate; ATPase; adenosine triphosphatase; BER; base excision repair; Ca2+; calcium ions; CDKN1A; cyclin-dependent kinase inhibitor 1A; CHO; Chinese hamster ovary; COX-2; cycloox
Keywords: AHR; aryl hydrocarbon receptor; AIP; aryl hydrocarbon receptor interacting protein; BMP-4; bone morphogenetic protein 4; CDK; cyclin-dependent kinases; CDKN1A; cyclin-dependent kinase inhibitor 1A; CDKN1B; cyclin-dependent kinase inhibitor 1B; CDKN2A; cyc
Keywords: PAL; phenylalanine ammonia-lyase; C4H; cinnamic acid 4-hydroxylase; 4CL; 4-coumarate:coenzyme A ligase; CHI; chalcone isomerase; CHS; chalcone-synthase; CHR; chalcone reductase; G2-DT; glycinol 2-dimethylallyl transferase; G4-DT; glycinol 4-dimethylallyl
Decreased osteoprogenitor proliferation precedes attenuation of cancellous bone formation in ovariectomized rats treated with sclerostin antibody
Keywords: ANOVA; analysis of variance; BrdU; 5-bromo-2â²-deoxyuridine; CDKN1A; cyclin-dependent kinase inhibitor 1A; CDKN2A; CDKN inhibitor 2A; CE; coefficient of error; CV; coefficient of variation; D; day; E2F1; E2F transcription factor 1; FOXM1; Forkhead box pr
Clinical significance and functions of microRNA-93/CDKN1A axis in human cervical cancer
Keywords: Cervical cancer; MicroRNA-93; CDKN1A; Clinicopathologic feature; Prognosis; Proliferation; Invasion;
KIAA0101 inhibition suppresses cell proliferation and cell cycle progression by promoting the interaction between p53 and Sp1 in breast cancer
Keywords: KIAA0101; CCNE2; CDK6; CDKN1A; Sp1; Breast cancer;
Effects of microRNAs on skeletal muscle development
Keywords: HDAC4; histone deacetylase 4; SRF; serum response factor; Pax3; paired box protein pax-3; Pax7; paired box protein pax-7; 3â²UTR; 3â² untranslated region; MEF2A; myocyte-specific enhancer factor 2A; Mef2d; myocyte-specific enhancer factor 2D; Myf5; myog
Tumor suppressive ZBTB4 inhibits cell growth by regulating cell cycle progression and apoptosis in Ewing sarcoma
Keywords: ES; Ewing sarcoma; ZBTB4; zinc finger and BTB domain containing 4; CDKN1A; cyclin dependent kinase inhibitor 1A; ROS; reactive oxygen species; CLL; chronic lymphocytic leukemia; GEO; gene expression omnibus; SDS-PAGE; sodium dodecyl sulfate polyacrylamide
Exposure of human melanocytes to UVB twice and subsequent incubation leads to cellular senescence and senescence-associated pigmentation through the prolonged p53 expression
Keywords: UVR; ultraviolet radiation; UVsen; UVB-induced senescence; SAP; senescence-associated pigmentation; SA-β-Gal; senescence-associated β-galactosidase; TPA; tetradecanoyl phorbol acetate; CT; cholera toxin; pTpT; thymine dinucleotides; HEMn; human epiderma
Inhibition of hepatocellular carcinoma tumorigenesis by curcumin may be associated with CDKN1A and CTGF
Keywords: TFs; transcription factors; miRNAs; microRNAs; HCC; hepatic cancer; DEGs; differentially expressed genes; KEGG; Kyoto Encyclopedia of Genes and Genomes; PPIs; protein-protein interactions; OS; overall survival; NGS; next generation sequencing; MATHT; Mult
Importin-11 overexpression promotes the migration, invasion, and progression of bladder cancer associated with the deregulation of CDKN1A and THBS1
Keywords: Bladder cancer; Tumor progression; IPO11; CDKN1A; THBS1;
Î9-Tetrahydrocannabinol changes the brain lipidome and transcriptome differentially in the adolescent and the adult
Keywords: 2-AG; 2-arachidonoyl glycerol; AA; arachidonic acid; AEA; N-arachidonoyl ethanolamine; A-Taur; N-arachidonoyl taurine; Cdkn1a; cyclin dependent kinase inhibitor 1A; CER; cerebellum specific for this study; cldn5; claudin 5; CTX; cortex specific for this s
High-throughput gene expression analysis identifies p53-dependent and -independent pathways contributing to the adrenocortical dysplasia (acd) phenotype
Keywords: TPP1; protein encoded by adrenocortical dysplasia gene; Acd; adrenocortical dysplasia gene; acd; adrenocortical dysplasia mutation; p53; transformation related protein 53; DNA; Deoxyribonucleic acid; DC; Dyskeratosis congenita; HHS; Hoyeraal-Hreidarsson s
A Trichostatin A (TSA)/Sp1-mediated mechanism for the regulation of SALL2 tumor suppressor in Jurkat T cells
Keywords: AP4; Activating Protein 4; BAX; Bcl-2-associated X protein; Brd4; Bromodomain-containing protein 4; Brg1; Brahma-related gene-1; C2H2; Cys2-His2 zinc finger; CBP; CREB-binding protein; CDKN2A; Cyclin-Dependent Kinase Inhibitor 2A gene; CDKN1A; Cyclin-Depe
MicroRNAs in parathyroid physiopathology
Keywords: Parathyroid tumors; Hyperparathyroidism; PTH; miRNAs; C19MC; C19MC; chromosome 19 microRNA cluster; miR-372; microRNA-372; CDKN1A; cyclin-dependent kinase inhibitor 1A; TBX1; T-box 1; GCM2; glial cell missing 2; PTH; parathormone; CCND1; cyclin D1; CASR;
Long non-coding RNA PCAT-1 over-expression promotes proliferation and metastasis in gastric cancer cells through regulating CDKN1A
Keywords: PCAT-1; Prostate cancer-associated transcript1; DMSO; Dimethyl sulfoxide; FCM; Flow cytometry; PBS; Phosphate-buffered saline; PCAT-1; Gastric cancer; CDKN1A; lncRNA;
Research ArticleGene expression changes in colon tissues from colorectal cancer patients following the intake of an ellagitannin-containing pomegranate extract: a randomized clinical trial
Keywords: ABCG2; ATP-binding cassette subfamily G member 2 gene; APC; adenomatous polyposis coli gene; BIRC5; baculoviral inhibitor of apoptosis repeat-containing 5 gene; CASP3; apoptosis-related cysteine peptidase (caspase 3) gene; CDKN1A; cyclin-dependent kinase
Effects of mild ozonisation on gene expression and nuclear domains organization in vitro
Keywords: SH-SY5Y; Human neuroblastoma cell line; HMOX1; Heme Oxygenase 1; ERCC4; Excision Repair Cross-Complementation Group 4; CDKN1A; Cyclin-Dependent Kinase Inhibitor 1A; CTDSP1; CTD Small Phosphatase 1; Ozone; Human neuroblastoma cells; Cell nucleus; Transmiss
G2/M cell cycle arrest on HT-29 cancer cells and toxicity assessment of triphenylphosphanegold(I) carbonimidothioates, Ph3PAu[SC(OR)Â =Â NPh], RÂ =Â Me, Et, and iPr, during zebrafish development
Keywords: Annexin V-FITC; Recombinant annexin V conjugated to fluorescein isothiocyanate; APAF-1; Apoptotic protease activating factor 1; ATR; Ataxia telangiectasia and Rad3-related; Bax; Apoptosis regulator; Bcl-2; B-cell lymphoma 2; BIRC-5; Baculoviral inhibitor
Nephrotoxicity of epigenetic inhibitors used for the treatment of cancer
Keywords: Epigenetic inhibitors; Prostate cancer; Kidney cells; Nephrotoxicity; 5-Aza; 5-aza-2ʹ-deoxycytidine; CBZ; carbamazapine; CDK; cyclin-dependent kinase; CDKN1a; cyclin-dependent kinase inhibitor 1a; CFZ; carfilzomib; ChIP; chromatin immunoprecipitation; DM
Compression regulates gene expression of chondrocytes through HDAC4 nuclear relocation via PP2A-dependent HDAC4 dephosphorylation
Keywords: HDAC4; histone deacetylase 4; GFP; green fluorescent protein; PI; propidium iodide; PP2A; Ser/Thr-phosphoprotein phosphatases 2A; OA; okadaic acid; Ps-HDAC4; phosphorylated-HDAC4; LK1; polo-like kinase 1; CDKN1A; cyclin-dependent kinase inhibitor 1A; Mech
p21CIP1/WAF1-dependent inhibition of cardiac hypertrophy in response to Angiotensin II involves Akt/Myc and pRb signaling
Keywords: p21; Cdkn1a; p27; Cdkn1b; Myc; Retinoblastoma; Cyclin D2; Cdk; Cell cycle; Cardiac hypertrophy; Heart failure; Cardiac fibrosis; Angiotensin
A rare DNA contact mutation in cancer confers p53 gain-of-function and tumor cell survival via TNFAIP8 induction
Keywords: Mutant p53; Gain of function; Pro-survival; TNFα; Bax; BCL-2 associated X protein; CDKN1A; cyclin-dependent kinase inhibitor 1A; CPT; camptothecin; NF-κB; nuclear factor κB; qRT-PCR; quantitative real time polymerase chain reaction; Tet; tetracycline;
Cataractogenesis following high-LET radiation exposure
Keywords: A-bomb; atomic bomb; amu; atomic mass unit; ATM; ataxia telangiectasia mutated; BNCT; boron neutron capture therapy; BPA; boronophenylalanine; BSH; sodium borocaptate; CDK1; cyclin dependent kinase 1; CDKN1A; cyclin dependent kinase inhibitor 1A; CHK2; ch
Rescue of gene-expression changes in an induced mouse model of spinal muscular atrophy by an antisense oligonucleotide that promotes inclusion of SMN2 exon 7
Keywords: ASO; antisense oligonucleotide; Cdkn1A; cyclin-dependent kinase inhibitor 1A; cDNA; complementary DNA; FDR; false discovery rate; FUS; fused in sarcoma; Hist1H1C; histone cluster 1, H1C; ICV; intracerebroventricular; ISS; intronic splicing silencer; P; po
MiR-193a-3p promotes the multi-chemoresistance of bladder cancer by targeting the HOXC9 gene
Keywords: BCa; bladder cancer; MiR; microRNA; HCC; hepatocellular cancer; Pi; pirarubicin; Pa; paclitaxel; Ad; adriamycin; EH; epirubicin hydrochloride; Ci; cisplatin; 5-FU; 5-fluorouracil; UTR; untranslated region; HOXC9; homeobox C9; TERT; telomerase reverse tran
The transcriptional regulator BCL6 participates in the secondary gene regulatory response to vitamin D
Keywords: 1,25(OH)2D3; 1,25-dihydroxyvitamin D3; BCL6; B-cell CLL/lymphoma 6; B2M; beta-2-microglobulin; ChIA-PET; chromatin interaction analysis by paired-end tag sequencing; ChIP; chromatin immunoprecipitation; ChIP-seq; ChIP sequencing; CDKN1A; cyclin-dependent
Pyruvate kinase isoenzyme M2 is a therapeutic target of gemcitabine-resistant pancreatic cancer cells
Keywords: Gem; gemictabine; PKM2; pyruvate kinase isoenzymes muscle type 2; CASP3/7; caspase 3 & 7; c. PARP; cleaved poly ADP ribose polymerase; BAX; BCL2-associated X protein; CDKN1A; cyclin-dependent kinase inhibitor 1A; BAK1; BCL2-antagonist; Bcl-xL; BCL2-like 1
Developmental exposure of aflatoxin B1 reversibly affects hippocampal neurogenesis targeting late-stage neural progenitor cells through suppression of cholinergic signaling in rats
Keywords: AFB1; aflatoxin B1; AFM1; aflatoxin M1; BDNF; brain-derived neurotrophic factor; BW; body weight; CA3; Cornu ammonis 3; CALB1; calbindin-D-28K; CALB2; calbindin-D-29K; Cdkn1a; cyclin-dependent kinase inhibitor 1A; Chat; choline O-acetyltransferase; CHRNA7
Coumarins as anticancer agents: A review on synthetic strategies, mechanism of action and SAR studies
Keywords: Coumarins; Anticancer; Synthesis; Targets; SAR; IC50; ARI; aromatase inhibitor; CAM; choriallanotoic membrane; CDC; cell cycle division protein; CDK2; cyclin dependent kinase 2; CDKN1A; cyclin-dependent kinase inhibitor 1A; CYP; cytochromes P450; DDIT4; D
Stable SREBP-1a knockdown decreases the cell proliferation rate in human preadipocyte cells without inducing senescence
Keywords: CDKN1A; cyclin-dependent kinase inhibitor 1A; CDKN2B; cyclin-dependent kinase inhibitor 2B; CDKN3; cyclin-dependent kinase inhibitor 3; H3K9me3; histone H3 lysine 9 trimethylation; MTT; 3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyltetrazolium bromide; RRBP8;
Interindividual variation in response to xenobiotic exposure established in precision-cut human liver slices
Keywords: AFB; aflatoxin B1; AhR; aryl hydrocarbon receptor; APAP; acetaminophen; BaP; benzo(α) pyrene; BMD; benchmark dose; BNA; Bayesian network analysis; BPDE; benzo(a) pyrene diolepoxide; CDKN1A; cyclin-dependent kinase inhibitor 1A; cDNA; copy DNA; CES; criti
FOG-2 mediated recruitment of the NuRD complex regulates cardiomyocyte proliferation during heart development
Keywords: Chromatin; Zfpm2; Cdkn1a
Vitamin D receptor signaling mechanisms: Integrated actions of a well-defined transcription factor
Keywords: 1α,25(OH)2D3; 1α,25-dihydroxyvitamin D3; 25(OH)D3; 25-hydroxyvitamin D3; ALOX5; arachidonate 5-lipoxygenase; AR; androgen receptor; CAMP; cathelicidin anti-microbial peptide; CCNC; cyclin C; CDKN1A; cyclin-dependent kinase inhibitor 1A; CoA; co-activato
MicroRNA-22 is down-regulated in hepatitis B virus-related hepatocellular carcinoma
Keywords: MicroRNAs; Hepatitis B virus (HBV); MiR-22; CDKN1A
S100A14 inhibits proliferation of oral carcinoma derived cells through G1-arrest
Keywords: S100A14; TP53; CDKN1A; Oral squamous cell carcinoma; Oral cancer;
Meta analysis of gene expression changes upon treatment of A549 cells with anti-cancer drugs to identify universal responses
Keywords: Meta-analysis; Gene expression; FDXR; CDKN1A; PARVB; MYC; HBP1; LDLR; SIM2; ALX1; GPHN; A549 lung adenocarcinoma cell line; Anti-cancer drugs;
PCNA-dependent accumulation of CDKN1A into nuclear foci after ionizing irradiation
Keywords: LET; linear energy transfer; DSBs; DNA double-strand breaks; SSBs; DNA single-strand breaks; CPD; cumulative population doublings; NHDF; neonatal human dermal fibroblasts; TLC; thin-layer cellulose; ICQ; Intensity Correlation Quotient; ICA; Image Correlat
Pulmonary toxicity after exposure to military-relevant heavy metal tungsten alloy particles
Keywords: BAL; bronchoalveolar lavage; Cdkn1a; cyclin-dependent kinase inhibitor 1A; CINC; cytokine-induced neutrophil chemoattractant; CYP2A3; cytochrome P450, family 2, subfamily A, polypeptide 3; DCF; 2â²,7â²-dichlorodihydrofluorescein; DCFH-DA; 2â²,7â²-dich
Long-lasting transcriptional refractoriness triggered by a single exposure to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrimidine
Keywords: Cdkn1a; cyclin-dependent kinase inhibitor 1a; CDS; coding sequence; DA; dopamine; DOPAC; 3-4-dihydroxphenylacetic acid; EDTA; ethylenediaminetetraacetic acid; Edg3; endothelial differentiation, sphingolipid G-protein-coupled receptor 3; Fosb; FBJ murine o
Methylated chrysin, a dimethoxy flavone, partially suppresses the development of liver preneoplastic lesions induced by N-Nitrosodiethylamine in rats
Keywords: bcl 2; B Cell CLL/lymphoma-2; cdkn1a; Cyclin dependent kinase inhibitor 1A; chek 2; Cell-cycle checkpoint kinase2Â homolog (S.pombe); DEN; N-diethylnitrosamine; DMF; dimethyl flavone; fas; apoptosis stimulating fragment; GAPDH; Glyceraldehyde-3-phosphat
p21Cip1 regulates cell–substrate adhesion and interphase microtubule dynamics in untransformed human mammary epithelial cells
Keywords: CDKN1A; p21Cip1; Focal adhesion; Microtubule; HDAC6; Mammary epithelial cells; Breast cancer
Microcystin-LR induced apoptosis and mRNA expression of p53 and cdkn1a in liver of whitefish (Coregonus lavaretus L.)
Keywords: Apoptosis; p53; cdkn1a; mRNA expression; Microcystin-LR; Whitefish
Transcription of five p53- and Stat-3-Inducible genes after ionizing radiation
Keywords: Transcription; Biodosimetry; QRT-PCR; cdkn1a; gadd45a; bcl-2; bax; ddb-2; Stat-3; p53; Ionizing radiation;
IGFBP3 Promoter Methylation in Colorectal Cancer: Relationship with Microsatellite Instability, CpG Island Methylator Phenotype, p53
Keywords: Colon cancer; IGFBP3; methylation; CIMP; MSI; BAX; BCL2-associated X protein; CACNA1G; calcium channel; voltagedependent; T type alpha-1G subunit; CDKN1A; cyclin-dependent kinase inhibitor 1A (p21, CIP1); CDKN2A; cyclin-dependent kinase inhibitor 2A (p16,
Gene expression and apoptosis induction in p53-heterozygous irradiated mice
Keywords: p53-heterozygous mice; Ionising radiation; CDKN1A; bax; Apoptosis
The fate of p21CDKN1A in cells surviving UV-irradiation
Keywords: DNA damage; p21; CDKN1A; CIP1; UV-irradiation; Cell death;