Keywords: SOC and LOC; soil and litter organic carbon; STN and LTN; soil and litter total nitrogen; STP and LTP; soil and litter total phosphorus; SCN and LCN; soil and litter C:N ratio; SCP and LCP; soil and litter C:P ratio; SNP and LNP; soil and litter N:P ratio
مقالات ISI (ترجمه نشده)
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Keywords: Arginase deficiency; Hyperargininemia; Ammonia; Urea cycle disorder; Treatment; Cellular transplant; FAH; fumarylacetoacetate hydrolase; FRG; Fahâ/â/Rag2â/â/Il2rγâ/â mouse; CKO; conditional knockout; NTBC; 2-(2-nitro-4-trifluoromethylbenzoyl)
Keywords: ASD; autism spectrum disorders; BTBR; BTBR T+Itpr3tf/J mouse strain; cKO; conditional knockout; CNS; central nervous system; CNTNAP2; contactin-associated protein-like 2; DREADD; designer receptors exclusively activated by designer drugs; DSM-5; Diagnosti
Keywords: aCSF; artificial cerebrospinal fluid; cKO; conditional knockout; EGTA; ethylene glycol tetraacetic acid; fEPSPs; field excitatory postsynaptic potentials; HEPES; 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid; LTP; long-term potentiation; MGE; medial
Keywords: Crystalline lens; Ionizing radiation; DNA repair factors; Nontargeted effects; Inflammation; Tumor suppressors; A-bomb; atomic-bomb; Acvr1; activin A type 1 receptor; AP; apurinic/apyrimidinic; APE1; apurinic/apyrimidinic endonuclease 1; AQP; aquaporin; A
Keywords: LECs; lens epithelial cells; LFCs; lens fiber cells; ECM; extracellular matrix; IGF; insulin-like growth factor; OCFs; outer cortical fibers; ICFs; inner cortical fibers; F-actin; filamentous actin; cKO; conditional knockout; ILK; integrin linked kinase;
The p38α MAPK Deletion in Oligodendroglia does not Attenuate Myelination Defects in a Mouse Model of Periventricular Leukomalacia
Keywords: CKO; conditional knockout; CNS; central nervous system; EAE; experimental autoimmune encephalomyelitis; GFP; green fluorescent protein; LPS; lipopolysaccharide; MAPK; mitogen-activated protein kinase; MBP; myelin basic protein; NG2; neuron-glial antigen 2
Myelin volume fraction imaging with MRI
Keywords: MRI; magnetic resonance imaging; MWF; myelin water fraction; BPF; bound pool fraction; fM,T2; myelin volume fraction from MWF; fM,MT; myelin volume fraction from BPF; MVF; myelin volume fraction; AVF; axon volume fraction; fM,HIST; myelin volume fraction
Functional significance of O-GlcNAc modification in regulating neuronal properties
Keywords: PTM; post-translational modification; OGT; O-GlcNAc transferase; OGA; O-GlcNAcase; O-GlcNAc; O-linked β-N-acetylglucosamine; UDP-GlcNAc; uridine diphosphate N-acetylglucosamine; GalNAc; N-acetylgalactosamine; Gal; galactose; PSD; postsynaptic density; NF
Presenilin gene function and Notch signaling feedback regulation in the developing mouse lens
Keywords: CKO; “conditional knock-out” allele; ICD; intracellular domain; NEXT; Notch extracellular truncation; PLE; presumptive lens ectoderm; AEL; anterior epithelial layer; E0.5; embryonic day 0.5; H&E; hematoxylin and eosin; OCT; optimal cutting temperature
TGF-β Signaling Regulates Development of Midbrain Dopaminergic and Hindbrain Serotonergic Neuron Subgroups
Keywords: 5-HT; 5-hydroxytryptamine; Aldh1a1; aldehyde dehydrogenase 1 family member A1; Cck; cholecystokinin; cKO; conditional knockout; DIV; day in vitro; DR; dorsal raphe; MR; median raphe; PMR; paramedian raphe; RM; raphe magnus; En1; engrailed 1; ES; embryonic
The histone demethylase Kdm6b regulates a mature gene expression program in differentiating cerebellar granule neurons
Keywords: CGNs; cerebellar granule neurons; GNPs; granule neuron precursors; EGL; external granule layer; IGL; internal granule layer; H3K4me1 or H3K4me3; histone H3 lysine 4 monomethylation or trimethylation; H3K27me3; histone H3 lysine 27 trimethylation; JmjC; ju
Dissecting Wnt Signaling for Melanocyte Regulation during Wound Healing
Keywords: cKO; conditional knockout; McSC; melanocyte stem cell; TAM; tamoxifen; Tyr; tyrosinase;
La involvement in tRNA and other RNA processing events including differences among yeast and other eukaryotes
Keywords: cKO; conditional knockout; DFC; dense fibrillar component; LaM; La motif; LARP; La-related protein; m7G-cap; 7-methyl-guanosine-cap; RRM; RNA recognition motif; RNAP; RNA polymerase; snRNA; small nuclear RNA; tRFs; tRNA fragments; tRNAome; tRNA gene conte
MiR-31 Mediates Inflammatory Signaling to Promote Re-Epithelialization during Skin Wound Healing
Keywords: 3â²-UTR; 3â²-untranslated region; Ccnd1; Cyclin D1; cKO; conditional knockout; MAPK; mitogen-activated protein kinase; PWD; post wounding; siRNA; small interfering RNA; STAT3; signal transducer and activator of transcription 3; TNF-α; tumor necrosis fa
Nrf2 activator for the treatment of kidney diseases
Keywords: Kidney diseases; Nuclear factor erythroid 2-related factor 2 (Nrf2); Clinical endpoints; Glomerular filtration rate (GFR); ACEi; angiotensin-converting enzyme inhibitors; AKI; acute kidney injury; ALS; amyotrophic lateral sclerosis; ARB; angiotensin II re
E3-ubiquitin ligase NEDD4 enhances bone formation by removing TGFβ1-induced pSMAD1 in immature osteoblast
Keywords: NEDD4; neural precursor cell-expressed, developmentally down-regulated protein 4; TGFβ1; transforming growth factor β1; BMP2; bone morphogenetic protein 2; PI3K; phosphatidylinositol-4,5-bisphosphate 3-kinase; AKT (PKB); protein kinase B; ERK; extracell
Enhanced dendritic morphogenesis of adult hippocampal newborn neurons in central 5-HT-deficient mice
Keywords: 5-HT; 5-hydroxytryptophan; CKO; conditional knockout mice; DT; diphtheria toxin; DTR; diphtheria toxin receptor; Lmx1bPet1; Pet1-Cre;Lmx1bflox/flox; KO; knockout; retro-GFP; GFP-encoding retrovirus; Rosa26-DTRPet1; Pet1-Cre;Rosa26-DTR; Sert; serotonin tra
Research PaperMice with conditional NeuroD1 knockout display reduced aberrant hippocampal neurogenesis but no change in epileptic seizures
Keywords: SRS; spontaneous recurring seizures; TLE; temporal lobe epilepsy; GCL; granule cell layer; SGZ; subgranular zone; DG; dentate gyrus; YFP; yellow fluorescent protein; KA; kainic acid; Dcx; doublecortin; cKO; conditional knock-out; WT; wildtype; ND1; NeuroD
Forebrain knock-out of torsinA reduces striatal free-water and impairs whole-brain functional connectivity in a symptomatic mouse model of DYT1 dystonia
Keywords: cKO; conditional knock-out; dMRI; diffusion magnetic resonance imaging; FC; functional connectivity; FW; free-water; KI; knock-in; KO; knock-out; MDT; free-water corrected mean diffusivity; rsfMRI; resting-state functional magnetic resonance imaging; SCI;
Slug Modulates UV Radiation-Induced Cutaneous Inflammation by Regulating Epidermal Production of Proinflammatory Cytokines
Keywords: CKO; conditional knockout; KO; knockout; OSM; oncostatin; TG; transgenic; WT; wild type;
Wls expression in the rhombic lip orchestrates the embryonic development of the mouse cerebellum
Keywords: BGC; Bergmann glia cell; cKO; conditional knockout; CN; cerebellar nuclear; CP; choroid plexus; E; embryonic; EGL; external germinal layer; eRL; exterior face of the rhombic lip; GCP; granule cell progenitor; GC; granule cell; IHC; immunohistochemical; iR
Osteogenesis imperfecta: new genes reveal novel mechanisms in bone dysplasia
Keywords: ADAMTS; A disintegrin and metalloprotease with thrombospondin motifs; AR-OI; autosomal recessive osteogenesis imperfecta; ATF6; activating transcription factor 6; ATGL; adipose triglyceride lipase; BiP; binding immunoglobulin protein; BMDD; bone mineraliz
GATA4 Is Sufficient to Establish Jejunal Versus Ileal Identity in the Small Intestine
Keywords: Transcriptional Regulation; Jejunal Identity; Enterohepatic Signaling; Fgf15; FXR; bio-ChIP-seq; biotin-mediated chromatin immunoprecipitation with high-throughput sequencing; bp; base pair; cDNA; complementary DNA; cKI; conditional knock-in; cKO; conditi
MicroRNA control of tooth formation and eruption
Keywords: RISC; RNA-induced silencing complex; miRNAs; microRNAs; UTR; untranslated region; cKO; conditional knockout; laCL; labial cervical loop; liCL; lingual cervical loop; DFC(s); dental follicle cell(s); MicroRNA; Tooth development; Amelogenesis; Odontoblast;
Deficiency of DGCR8 increases bone formation through downregulation of miR-22 expression
Keywords: DROSHA; drosha ribonuclease III; DGCR8; dgcr8 microprocessor complex; DICER; dicer ribonuclease III; Cre; cre recombinase protein; COLA1A; collagen type I alpha 1 chain; cKO; conditional knock-out; ES cell; embryonic stem cell; OSTEOCALCIN; bone gamma-car
Evaluation of diffusion kurtosis imaging in ex vivo hypomyelinated mouse brains
Keywords: AC; anterior commissure; AD; axial diffusivity; AK; axial kurtosis; CKO; conditional knockout; da; axon diameter; Da; intra-axonal diffusivity; De,||; extra-axonal axial diffusivity; De,â¥; extra-axonal radial diffusivity; DKI; diffusion kurtosis imaging
Critical role of JSAP1 and JLP in axonal transport in the cerebellar Purkinje cells of mice
Keywords: APP; amyloid precursor protein; cDKO; conditional double KO; cKO; conditional KO; cTKO; conditional triple KO; Cyt c; cytochrome c; DAPI; 4,6-diamidino-2-phenylindole; DCN; deep cerebellar nuclei; floxed; loxP-flanked; GFAP; glial fibrillary acidic protei
β-Catenin is required for maintaining hippocampal morphology during the perinatal period
Keywords: BCIP; 5-bromo-4-chloro-3-indolyl-phosphate; BSA; Bovine Serum Albumin; CA; Cornu Ammonis; CKO; conditional knockout; DG; dentate gyrus; EDTA; ethylenediaminetetraacetic acid; GFAP; glial fibrillary acidic protein; ISH; In situ hybridization; NBT; nitro bl
Connexin26 (GJB2) deficiency reduces active cochlear amplification leading to late-onset hearing loss
Keywords: 4-HTMX; 4-hydroxytamoxifen; ABR; auditory brainstem response; cKO; conditional knockout; DPOAE; distortion product otoacoustic emission; EP; endocochlear potential; KO; knockout; NLC; nonlinear capacitance; OHC; outer hair cells; gap junction; connexin; C
Loss of sirtuin 1 (SIRT1) disrupts skin barrier integrity and sensitizes mice to epicutaneous allergen challenge
Keywords: Sirtuin 1 (SIRT1); skin barrier; filaggrin; AD; Atopic dermatitis; AhR; Aryl hydrocarbon receptor; ARNT; Aryl hydrocarbon receptor nuclear translocator; BaP; Benzo(a)pyrene; cHet; Epidermis-specific heterozygous SIRT1 deletion; cKO; Epidermis-specific hom
MicroRNAs in skin tissue engineering
Keywords: APC; antigen producing cell; Ago; argonaute protein; αSMA; alpha smooth muscle actin; BSE; bioengineered skin equivalent; CEA; cultured epithelial autograft; cKO; conditional knockout; CREB1; p-cAMP response element-binding protein 1; DMD; Duchenne muscu
APC controls asymmetric Wnt/β-catenin signaling and cardiomyocyte proliferation gradient in the heart
Keywords: APC; adenomatosis polyposis coli; cKO; conditional knockout; CM; cardiomyocyte; E; embryonic day; WT; wild type; Adenomatosis polyposis coli (APC); β-catenin; Heart; Development; Wnt; Proliferation;
TbGT8 is a bifunctional glycosyltransferase that elaborates N-linked glycans on a protein phosphatase AcP115 and a GPI-anchor modifying glycan in Trypanosoma brucei
Keywords: CBB; Coomassie brilliant blue; cKO; conditional double knockout; FP; flagellar pocket and lysosome/endosome system; GlcNAc; N-acetylglucosamine; GPI; glycosylphosphatidylinositol; HA; hemagglutinin epitope; LacNAc; N-acetyllactosamine; PBS; phosphate buff
MicroRNA processing machinery in the developing chick embryo
Keywords: ncRNA; non-coding RNA; miRNA; microRNA; RISC; RNA-induced silencing complex; pri-miRNA; primary miRNA; pre-miRNA; precursor miRNA; cKO; conditional KO; HH; Hamburger and Hamilton; PSM; presomitic mesoderm; P-PSM; prospective presomitic mesoderm; LPM; late
The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration
Keywords: AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; AMPAR; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors; ATP; adenosine triphosphate; Aβ; amyloid β peptide; AD; Alzheimer's disease; APP; amyloid precursor protein; AMP; adenos
Research ArticleDifferential regulation of inflammation and apoptosis in Fas-resistant hepatocyte-specific Bid-deficient mice
Keywords: hBidâ/â; hepatocyte-specific Bid knockout; cKO; conditional knockout; Bidfl/fl; albumin-cre negative Bid flox/flox control; WT; wild-type; TUNEL; terminal desoxynucleotidyl transferase-mediated dUTP-biotin nick and labeling; MIP; macrophage inflammato
How does Reelin control neuronal migration and layer formation in the developing mammalian neocortex?
Keywords: Dab1; disabled homolog 1; ApoER2; apolipoprotein E receptor 2; VLDLR; very-low-density lipoprotein receptor; VZ; ventricular zone; SVZ; subventricular zone; MAZ; multipolar cell accumulation zone; CP; cortical plate; IZ; intermediate zone; MZ; marginal zo
Age-dependent neuron loss is associated with impaired adult neurogenesis in forebrain neuron-specific Dicer conditional knockout mice
Keywords: miRNA; microRNA; cKO; conditional knockout; AD; Alzheimer's disease; DG; dentate gyrus; SGZ; subgranular zone; SVZ; subventricular zone; GCL; granular cell layer; MAP2; microtubule-associated protein; SVP38; synaptophysin; GFAP; glial fibrillary acidic pr
In Vivo Mn-Enhanced MRI for Early Tumor Detection and Growth Rate Analysis in a Mouse Medulloblastoma Model
Keywords: 2D; two-dimensional; 3D; three-dimensional; Cb; cerebellum; CKO; conditional knockout; GCP; granule cell precursor; IHC; immunohistochemistry; MB; medulloblastoma; MEMRI; Mn-enhanced MRI; Mn; manganese; MRI; magnetic resonance imaging; Ptch1; Patched-1; S
Autophagy-mediated degradation is necessary for regression of cardiac hypertrophy during ventricular unloading
Keywords: CKO; cardiac-specific Atg5-deficient mice; CTL; control mice; TAC; thoracic transverse aortic constriction; HW; heart weight; LV; left ventricle; LVW; left ventricle weight; IVSd; end-diastolic interventricular septal thickness; LVPWd; end-diastolic left
Role for Lhx2 in corticogenesis through regulation of progenitor differentiation
Keywords: cKO; conditional knockout; dTel; dorsal telencephalon; SVZ; subventricular zone; VZ; ventricular zone; WT; wild type; Cortical neurogenesis; Lhx2; Hes1; Notch; floxed Lhx2;
Mcl-1 regulates the survival of adult neural precursor cells
Keywords: Bcl-2; B cell lymphoma 2; Bcl-xL; B cell lymphoma X large fragment; CKO; conditional knockout; BrdU; Bromodeoxyuridine; Cre; Cre recombinase; CMV; cytomegalovirus; Dcx; Doublecortin; DIV; days in vitro; FGF-2; fibroblast growth factor 2; GFAP; glial fibri
Laminin α1 is essential for mouse cerebellar development
Keywords: CKO; conditional Lama1 knockout; CNS; central nervous system; Cont; control; ECM; extracellular matrix; EGL; external granule layer; GCPs; distorted the layer granule cell precursors; IGL; internal granule layer; Laminin α1 chain; Meninges; Cerebellum;
CCL2-Induced Migration and SOCS3-Mediated Activation of Macrophages Are Involved in Cerulein-Induced Pancreatitis in Mice
Keywords: Immune Response; Signaling; Mouse Model; Chemokine; APC; antigen-presenting cell; BM; bone marrow; cDC; classical dendritic cells; cKO; conditional knockout; IL; interleukin; L-Arg; L-arginine; LPS; lipopolysaccharide; MDSC; myeloid-derived suppressor cel
Brief CommunicationPET imaging for attention deficit preclinical drug testing in neurofibromatosis-1 mice
Keywords: ADD; Attention Deficit Disorder; cAMP; cyclic adenosine monophosphate; CKO; conditional knockout; CT; computerized tomography; DA; dopamine; GEM; genetically-engineered mouse; MPH; methylphenidate; PET; positron emission tomography; Dopamine; Behavior; Ne
Regulation of remyelination in multiple sclerosis
Keywords: Remyelination; Oligodendrocytes; Hyaluronan; Wnt; Notch1; Retinoid X receptor; 15d-PGJ(2); 15-deoxy-Î12,14-prostaglandin J2; CNP; 2â²,3â²-cyclic nucleotide 3â²-phosphodiesterase; CNS; central nervous system; cKO; conditional knockout; dpl; days post l
The activated aryl hydrocarbon receptor synergizes mitogen-induced murine liver hyperplasia
Keywords: AhR; Aryl hydrocarbon receptor; BrdU; bromodeoxyuridine; CKO; conditional knockout; CDK; cyclin-dependent kinase; PH; partial hepatectomy; TCDD; 2,3,7,8-tetrachlorodibenzo-p-dioxin; TCPOBOP; 1,4-bis[2-(3,5-dichloropyridyloxy)] benzene; TCPOBOP; TCDD; AhR;
The BMP signaling and in vivo bone formation
Keywords: BMP; bone morphogenetic protein; TGFb; transforming growth factor b; BMPR; BMP receptor; Runx2; Runt-related gene 2; Smad; Sma/Mad; GDF; growth/differentiation factor; CKO; conditional knockout; Smurf1; Smad ubiquitin regulatory factor 1;