کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10757584 | 1050396 | 2013 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Autophagy-mediated degradation is necessary for regression of cardiac hypertrophy during ventricular unloading
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
LVIDdMLC2vLVWLVPWdLVIDsIVSdCTLcKOLC3TACAngiotensin II - آنژیوتانسین دوCardiac remodeling - بازسازی قلبleft ventricle - بطن چپPressure overload - بیش از حد فشارHeart - قلب Hypertrophy - هیپرتروفی یا پُرسازیHeart weight - وزن قلبmicrotubule-associated protein 1 light chain 3 - پروتئین مرتبط با میکروتوبول 1 زنجیره سبک 3fractional shortening - کوتاه کردن کسری
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Autophagy-mediated degradation is necessary for regression of cardiac hypertrophy during ventricular unloading Autophagy-mediated degradation is necessary for regression of cardiac hypertrophy during ventricular unloading](/preview/png/10757584.png)
چکیده انگلیسی
Cardiac hypertrophy occurs in response to a variety of stresses as a compensatory mechanism to maintain cardiac output and normalize wall stress. Prevention or regression of cardiac hypertrophy can be a major therapeutic target. Although regression of cardiac hypertrophy occurs after control of etiological factors, the molecular mechanisms remain to be clarified. In the present study, we investigated the role of autophagy in regression of cardiac hypertrophy. Wild-type mice showed cardiac hypertrophy after continuous infusion of angiotensin II for 14Â days using osmotic minipumps, and regression of cardiac hypertrophy was observed 7Â days after removal of the minipumps. Autophagy was induced during regression of cardiac hypertrophy, as evidenced by an increase in microtubule-associated protein 1 light chain 3 (LC3)-II protein level. Then, we subjected cardiac-specific Atg5-deficient (CKO) and control mice (CTL) to angiotensin II infusion for 14Â days. CKO and CTL developed cardiac hypertrophy to a similar degree without contractile dysfunction. Seven days after removal of the minipumps, CKO showed significantly less regression of cardiac hypertrophy compared with CTL. Regression of pressure overload-induced cardiac hypertrophy after unloading was also attenuated in CKO. These results suggest that autophagy is necessary for regression of cardiac hypertrophy during unloading of neurohumoral and hemodynamic stress.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 441, Issue 4, 29 November 2013, Pages 787-792
Journal: Biochemical and Biophysical Research Communications - Volume 441, Issue 4, 29 November 2013, Pages 787-792
نویسندگان
Jota Oyabu, Osamu Yamaguchi, Shungo Hikoso, Toshihiro Takeda, Takafumi Oka, Tomokazu Murakawa, Hiroki Yasui, Hiromichi Ueda, Hiroyuki Nakayama, Manabu Taneike, Shigemiki Omiya, Ajay M. Shah, Kazuhiko Nishida, Kinya Otsu,