Lack of biological relevance of platelet cyclooxygenase-2 dependent thromboxane A2 production
Keywords: Aspirin; COX-1; COX-2; Platelets; Thromboxane A2
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Effect of the oral absorption of benzenesulfonanilide-type cyclooxygenase-1 inhibitors on analgesic action and gastric ulcer formation
Keywords: cyclooxygenase; COX; COX-1; COX-1-selective inhibitor; sulfonamide; analgesic; absorption; gastric damage; writhing test; formalin test;
Expression of cyclooxygenase genes and production of prostaglandins during ovulation in the ovarian follicles of Xenopus laevis
Keywords: Cyclooxygenase; COX-1; COX-2; Prostaglandins; Ovulation; Xenopus laevis
Spinal nerve ligation-induced activation of nuclear factor kappaB is facilitated by prostaglandins in the affected spinal cord and is a critical step in the development of mechanical allodynia
Keywords: NFκB; spinal prostaglandins; spinal nerve ligation; spinal hyperexcitability; allodynia; cyclooxygenase; AFRR; A-fiber-mediated reflex responses; ANOVA; analysis of variance; CFRR; C-fiber-mediated reflex responses; COX; cyclooxygenase; COX-1; cyclooxyge
A phylogeny of the oil bee tribe Ctenoplectrini (Hymenoptera: Anthophila) based on mitochondrial and nuclear data: Evidence for Early Eocene divergence and repeated out-of-Africa dispersal
Keywords: Biogeography; Ctenoplectra; Ctenoplectrina; cox-1; CAD; cytb; Ef1-α; Molecular clocks; cox-1 pseudogenes
An Update on Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) in Small Animals
Keywords: NSAIDs; Anti-inflammatory drugs; Analgesic drugs; Dogs; Cats; Pain; Arthritis; COX-1;
Expression of cyclooxygenase-1 and cyclooxygenase-2 in the normal human heart and in myocardial infarction
Keywords: Cyclooxygenase; COX-1; COX-2; Myocardial infarction; Normal heart
5-Heteroatom substituted pyrazoles as canine COX-2 inhibitors. Part III: Molecular modeling studies on binding contribution of 1-(5-methylsulfonyl)pyrid-2-yl and 4-nitrile
Keywords: Canine; Cyclooxygenase; COX-1; COX-2; Pyrazole; Heterocyle; Molecular modelling;
Expression of COX-1 and COX-2 in a Clinical Model of Acute Inflammation
Keywords: COX-1; COX-2; cyclooxygenase; inflammation; lipopolysaccharides; NSAID; prostaglandin; polymorphonuclear
Peripheral Formalin Injection Induces Long-Lasting Increases in Cyclooxygenase 1 Expression by Microglia in the Spinal Cord
Keywords: Formalin test; pain; prostaglandins; glia; COX-1; COX-2
NSAIDs and Alzheimer disease: Epidemiological, animal model and clinical studies
Keywords: Activated microglia; Inflammation; Transgenic mice; COX-1; COX-2; Amyloid; Neurofibrillary tangles
‘Bridged’ stilbene derivatives as selective cyclooxygenase-1 inhibitors
Keywords: COX-inhibition; Resveratrol; COX-1; Stilbene; Docking model
Synthesis and biological activity of vicinal diaryl-substituted 1H-imidazoles
Keywords: Imidazoles; Synthesis; Selectivity; Bioactivity; Enzyme inhibitors; Ac; acetyl; Ar; aryl; Betmip; 1-(benzotriazol-1-yl)-N-(triphenylphosphorylidene)-methylamine; Bn; benzyl; Bt; benzotriazol-1-yl; Bz; benzoyl; COX-1; cyclooxygenase-1; COX-2; cyclooxygenas
Anti-angiogenic activity of basic-type, selective cyclooxygenase (COX)-1 inhibitors
Keywords: Angiogenesis; COX-1; COX-1 inhibitor; HUVEC;
5-Heteroatom-substituted pyrazoles as canine COX-2 inhibitors: Part 2. Structure–activity relationship studies of 5-alkylethers and 5-thioethers
Keywords: Pyrazoles; Heteroatom; COX-1; COX-2; Aanine; SAR
Prostaglandin-H-synthase (PGHS)-1 and -2 microtiter assays for the testing of herbal drugs and in vitro inhibition of PGHS-isoenzyms by polyunsaturated fatty acids from Platycodi radix
Keywords: COX-1; COX-2; In vitro assays; Chinese herbs; Platycodon grandiflorum; Fatty acids; PGHS-isoenzymes
The role of the cylooxygenase pathway in nociception and pain
Keywords: COX-1; COX-2; Pain; Prostanoid; Review
Efectos gastrointestinales graves por antiinflamatorios no esteroideos. Un problema no resuelto
Keywords: Antiinflamatorios no esteroideos (AINE); COX-1; COX-2; Efectos gastrointestinales; GastropatÃa; Nonsteroidal anti-inflammatory drugs (NSAIDs); COX-1; COX-2; Gastrointestinal effects; Gastropathy;
Tetrahedron report number 762Synthesis and biological activity of pyrrole, pyrroline and pyrrolidine derivatives with two aryl groups on adjacent positions
Keywords: Pyrroles; Pyrrolines; Pyrrolidines; Synthesis; Bioactivity; Natural products; Ac; acetyl; Ar; aryl; Bn; benzyl; Bt; benzotriazol-1-yl; COX-1; cyclooxygenase-1; COX-2; cyclooxygenase-2; DBU; 1,8-diazabicyclo[5.4.0]undec-7-ene; DMF; dimethylformamide; DMPA;
Localization of cyclooxygenases-1 and -2, and prostaglandin F synthase in human kidney and renal cell carcinoma
Keywords: Cyclooxygenase; COX-1; COX-2; Prostaglandin; PGF; PGF synthase; Immunochemistry; Kidney;
Overestimation of Platelet Aspirin Resistance Detection by Thrombelastograph Platelet Mapping and Validation by Conventional Aggregometry Using Arachidonic Acid Stimulation
Keywords: AA; arachidonic acid; ADP; adenosine diphosphate; COX-1; cyclooxygenase-1; GP; glycoprotein; LTA; light-transmittance aggregometry; MAAA; arachidonic acid-induced clot strength (measurement of aspirin effect); MAfibrin; activator-induced clot strength (me
Design, synthesis, biological evaluation and molecular docking of curcumin analogues as antioxidant, cyclooxygenase inhibitory and anti-inflammatory agents
Keywords: Curcuminoids; Pyrazole analogues; Isoxazole analogues; COX-1; COX-2; Anti-inflammatory activity; Antioxidant activity;
Antinociceptive and anti-inflammatory activities of Acacia pennata wild (Mimosaceae)
Keywords: NSAIDs; non-steroidal anti-inflammatory drugs; COX-1; cyclooxygenase 1; COX-2; cyclooxygenase 2; 5-LO; 5-lipoxygenase; TLC; thin layer chromatography; NP/PEG; natural products-polyethylene glycol; 5-HT; 5-hydroxytryptamine (serotonine); bAP; butanolic Aca
QSAR analyses of conformationally restricted 1,5-diaryl pyrazoles as selective COX-2 inhibitors: application of connection table representation of ligands
Keywords: QSAR; COX-2; COX-1; MOE and connection table representation
Fast, efficient reconstitution of the cyclooxygenases into proteoliposomes
Keywords: Cyclooxygenases; COX-1; COX-2; Liposomes; EPR;
QSAR studies on structurally similar 2-(4-methanesulfonylphenyl)pyran-4-ones as selective COX-2 inhibitors: a Hansch approach
Keywords: QSAR; COX-2; COX-1; Selectivity; 2-Phenylpyran-4-ones;
High dietary fat induces NADPH oxidase-associated oxidative stress and inflammation in rat cerebral cortex
Keywords: High fat diet; Oxidative stress; NADPH oxidase; Inflammation; PGE2; COX-1; COX-2; NF-κB;
Cytochrome-c oxidase is one of several genes elevated in marginal retina of the chick embryo
Keywords: cytochrome c-oxidase; ciliary margin; differential display; cell proliferation; retinal development; stem cells; cDNA; complementary DNA; COX-1; cytochrome-c oxidase I; DD-RT-PCR; differential display-reverse transcription-polymerase chain reaction; DIG;
Marked increase of fibrin gel permeability with very low dose ASA treatment
Keywords: ASA; acetylsalicylic acid; COX-1; platelet cyclooxygenase; FXIII; Factor XIII; 3D confocal microscopy; three-dimensional confocal microscopy; BMI; body mass index; Ks; permeability coefficient (Darcy constant); μ; fibrin fiber/mass ratio; ASA treatment;
Inhibition of sequestosome 1/p62 up-regulation prevents aggregation of ubiquitinated proteins induced by prostaglandin J2 without reducing its neurotoxicity
Keywords: CFTR; cystic fibrosis transmembrane conductance regulator; COX-1; cyclooxygenase 1; DALIS; dendritic cell aggresome-like-induced structures; DMSO; dimethyl sulfoxide; DRiPs; defective ribosomal products; DTT; dithiothreitol; GFP; green fluorescent protein
Inhibitory effect of Buthus martensi Karsch extracts on interleukin-1β-induced expression of nitric oxide (NO) synthase and production of NO in human chondrocytes and LPS-induced NO and prostaglandin E2 production in mouse peritoneal macrophages
Keywords: BMK; Buthus martensi Karsch; (IL-1β); interleukin-1β; PGE2; prostaglandin E2; NO; nitric oxide; iNOS; inducible NO synthase; COX-2; cyclooxygenase-2; COX-1; cyclooxygenase-1; NF-κB; nuclear factor-κB; AP-1; activation protein-1; OA; osteoarthritis; ec
Design and synthesis of subtype-selective cyclooxygenase (COX) inhibitors derived from thalidomide
Keywords: COX-1; COX-1 selectivity; Indoline derivatives; Indole derivatives
Comparison of developmental toxicity of selective and non-selective cyclooxygenase-2 inhibitors in CRL:(WI)WUBR Wistar rats - DFU and piroxicam study
Keywords: COX-1; COX-2; Cyclooxygenase; Gastroschisis; Non steroidal anti inflammatory drugs; NSAID; Omphalocele; Prenatal toxicity; Umbilical hernia; Ventricular septal defect;
Response of mouse skin to tattooing: use of SKH-1 mice as a surrogate model for human tattooing
Keywords: Tattoo; Skin; Lymph node; NF-κB; COX-1; COX-2; ODC; IL-1β; IL-10;
Role of peroxidases in Parkinson disease: a hypothesis
Keywords: COX-1; cyclooxygenase-1; COX-2; cyclooxygenase-2; IFN-γ; interferon-γ; IL-1β; interleukin-β; LPS; lipopolysaccharide; MAO-B; monoamine oxidase B; MPTP; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; MPDP; 1-methyl-4-phenyl-1,2-dihydropyridine; MPP+; 1-
Non-COX-2 targets and cancer: Expanding the molecular target repertoire of chemoprevention
Keywords: COX-1; COX-2; COX-2 independent targets; Chemoprevention; Cancer; NSAIDs;
Skeletal developmental effects of selective and nonselective cyclooxygenase-2 inhibitors administered through organogenesis and fetogenesis in Wistar CRL:(WI)WUBR rats
Keywords: Bone development; COX-1; COX-2; Cyclooxygenase; Fetus; NSAID; Pregnancy; Skeleton;