Keywords: solubility; dissolution; permeability; oral absorption; species difference; dog; BCS; Fa; fraction of oral dose absorbed; Fah; Fa in humans; Fad; Fa in dogs; kel; elimination rate constant; Do; dose number; MAD; maximum absorbable dose; BW; body weight; F
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Keywords: BS; bile salt; Buf; buffer capacity; FaSSIF; fasted state simulated intestinal fluid; HEPES; 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid; MES; 2-(N-morpholino)ethanesulfonic acid; Osm; osmolarity; PL; phospholipid; RSD; relative standard deviation;
Keywords: BCS; biopharmaceutics classification system; DoE; design of experiment; FASSIF; fasted simulated intestinal fluid; FESSIF; fed simulated intestinal fluid; IVIVC; in vitro in vivo correlation; GIT; gastrointestinal tract; API; active pharmaceutical ingredi
Keywords: ACN; acetonitrile; API; active pharmaceutical ingredient; ASD; amorphous solid dispersion; BCS; biopharmaceutical classification system; CAP; cellulose acetate phthalate; DCM; dichloromethane; DMF; N,N-dimethylformamide; DL; drug load; DSC; differential s
Keywords: A4D; adapter 4 dialysis; API; active pharmaceutical ingredient; DLS; dynamic light scattering; EP; European Pharmacopoeia; FaSSGF; fasted state simulated gastric fluid; FaSSIF; fasted state simulated intestinal fluid; FaSSIF-V2; fasted state simulated int
Keywords: ASBT; apical sodium-dependent bile acid transporter; ASDs; amorphous solid dispersions; BACS; bile acid-CoA synthase; BAT; bile acid-amino acid transferase; BCS; biopharmaceutics classification system; BSH; bile salt hydrolase; C4; 7α-hydroxy-4-cholesten
Keywords: AUC; Area Under the Curve; API; Active Pharmaceutical Ingredient; Cmax; Maximum blood concentration; COPD; Chronic Obstructive Pulmonary Disease; DNX; Danirixin; HPLC; High Performance Liquid Chromatography; FaSSIF; Fasted State Simulated Intestinal Fluid
Keywords: equilibrium solubility and intrinsic dissolution rate; active pharmaceutical ingredients; rotating disk apparatus; drug particles; diffusion and surface dissolution kinetics; biologically relevant media; FaSSIF; FeSSIF; micelles; surfactants;
Keywords: BCS; Biopharmaceutics Classification System; DoE; Design of Experiment; FASSIF; Fasted Simulated Intestinal Fluid; FESSIF; Fed Simulated Intestinal Fluid; IVIVC; In vitro In vivo correlation; Fed simulated intestinal fluid; Design of experiment; Biopharma
Keywords: D/P system; dissolution/permeation system; DSC; differential scanning calorimetry; FaSSIF; fasted state simulated intestinal fluid; HCS; hydrocortisone; IS; internal standard; Jss; steady-state flux; LLOD; lower limit of detection; LLOQ; lower limit of qu
Keywords: AFM; atomic force microscopy; ASD; amorphous solid dispersion; AUC; area under curve; C; concentration; CS; solubility of crystalline drug; DS; degree of supersaturation; DSC; differential scanning calorimetry; EGF; excipient gain factor; FaSSIF; fasted-s
Keywords: salt; solubility; pH; dissolution; poorly water soluble; solution phase; solid phase; equilibrium; salt dissociation; phase-transformation; API; active pharmaceutical ingredient; AUC; area under curve; Cmax; maximum concentration; FaSSIF; fasted state sim
Keywords: API; active pharmaceutical ingredient; APGI; Association de Pharmacie Galénique Industrielle; BCS; biopharmaceutical classification system; EFPIA; European Federation of Pharmaceutical Industry Association; EMA; European Medicines Agency; FaSSIF; fasted
Keywords: supersaturation; preformulation; precipitation; oral drug delivery; gastrointestinal; excipients; SDDS; supersaturating drug delivery systems; DS; degree of supersaturation; tind; induction time; DMSO; dimethylsulfoxide; FaSSIF; fasted-state simulated int
Keywords: BPO; benzoyl peroxide; DCM; dichloromethane; DIPEA; N,N-diisopropylethylamine; DMF; N,N-dimethylformamide; DMSO; dimethyl sulfoxide; FaSSIF; fasted state simulated intestinal fluid; HATU; 1-[bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium
Keywords: FaSSIF, fasted state simulated intestinal fluid; PL, phospholipid; PC, phosphatidylcholine; GRIS, griseofulvin; TRE, trehalose; SD, spray dryingSpray drying; Büchi B-90; Bio-relevant media; Griseofulvin; FaSSIF; Pancreatin
Keywords: DDS; drug delivery system; PDI; polydispersity index; TEM; transmission electron microscopy; FaSSGF; fasted-state simulated gastric fluids; FeSSGF; fed-state simulated gastric fluids; FaSSIF; fasted-state simulated intestinal fluids; FeSSIF; fed-state sim
Keywords: HIV protease inhibitors; solubility; human intestinal fluids; FaSSIF; FeSSIF; food interactions; in vitro models; poorly water-soluble drugs; intestinal absorption;
Synthesis and profiling of benzylmorpholine 1,2,4,5-tetraoxane analogue N205: Towards tetraoxane scaffolds with potential for single dose cure of malaria
Keywords: AUC; area under the curve; BA; bioavailability; CLplasma; plasma clearance; CLint; intrinsic clearance; CYP; cytochrome P450; DCM; dichloromethane; DMF; dimethyl formamide; ED; effective dose; FaSSIF; fasted state simulated intestinal fluid; FeSSIF; fed s
Co-existing colloidal phases in artificial intestinal fluids assessed by AF4/MALLS and DLS: A systematic study into cholate & (lyso-) phospholipid blends, incorporating celecoxib as a model drug
Keywords: AF4; asymmetrical flow field-flow fractionation; CF; crossflow; CPP; critical packing parameter; CXB; celecoxib; DLS; dynamic light scattering; dRI; differential refractive index; FaSSIF; fasted state simulated fluid; FeSSIF; fed state simulated intestina
Ability of gelatin and BSA to stabilize the supersaturated state of poorly soluble drugs
Keywords: Solubility; Supersaturation; Protein; Gelatin; bovine serum albumin (BSA); Biopolymers; API; Active Pharmaceutical Ingredient; ASD; amorphous Solid Dispersion(s); AUC; Area Under the Curve; BCS; Biopharmaceutics Classification System; BSA; Bovine Serum Al
Use of biorelevant dissolution and PBPK modeling to predict oral drug absorption
Keywords: Biorelevant dissolution; Weak base; PBPK modeling; BCS class II; pH dependent solubility; ACAT; advanced compartmental absorption and transit model; ADAM; advanced dissolution, absorption and metabolism model; API; active pharmaceutical ingredient; ASD;
Research paperDissolution behavior of co-amorphous amino acid-indomethacin mixtures: The ability of amino acids to stabilize the supersaturated state of indomethacin
Keywords: AA; amino acid; ACN; acetonitrile; ARG; arginine; AUC; area under the curve; CA; co-amorphous; DMSO; dimethyl sulfoxide; DS; degree of supersaturation; DSC; differential scanning calorimetry; EGF; excipient gain factor; FaSSIF; fasted state simulated inte
Characterization of co-existing colloidal structures in fasted state simulated fluids FaSSIF: A comparative study using AF4/MALLS, DLS and DOSY
Keywords: Field-flow fractionation; Light scattering; Diffusion ordered spectroscopy; FaSSIF; Biomimetic; Intestinal fluid;
Surfactants enhance recovery of poorly soluble drugs during microdialysis sampling: Implications for in vitro dissolution-/permeation-studies
Keywords: FaSSIF; fasted state simulated intestinal fluid; SDS; sodium dodecyl sulfate; Jss; steady-state flux; LOD; limit of detection; LOQ; limit of quantification; M-D/P system; microdialysis-dissolution/permeation system; MWCO; molecular weight cut-off; UHPLC-U
Miniaturized INtrinsic DISsolution Screening (MINDISS) assay for preformulation
Keywords: DIDR; disk intrinsic dissolution rate; FaSSIF; fasted simulated small intestinal fluid; FeSSIF; fed simulated small intestinal fluid; MINDISS; Miniaturized INtrinsic DISsolution Screening; PASS; partially automated solubility screening; PEEK; polyethereth
The Evaluation of In Vitro Drug Dissolution of Commercially Available Oral Dosage Forms for Itraconazole in Gastrointestinal Simulator With Biorelevant Media
Keywords: precipitation; supersaturation; Caco-2 cells; dissolution; formulation; gastrointestinal; in vitro/in vivo correlations; intestinal absorption; permeability; cyclodextrins; AUC; area under the curve; AUDC; area under the dissolved drug amount-time curve
Research paperDoes the commonly used pH-stat method with back titration really quantify the enzymatic digestibility of lipid drug delivery systems? A case study on solid lipid nanoparticles (SLN)
Keywords: CEH; carboxyl ester hydrolase; cmc; critical micelle concentration; CP; cetyl palmitate; FA; fatty acids; FaSSIF; fasted state simulating medium; FeSSIF; fed state simulating medium; GIT; gastrointestinal tract; HPTLC; high performance thin layer chromato
PLGA nanoparticles for peroral delivery: How important is pancreatic digestion and can we control it?
Keywords: FaSSIF; fasted state simulated intestinal fluid; FeSSIF; simulated state intestinal fluid; NPs; nanoparticles; PDI; polydispersity index; PEG-PLA; pegylated poly(lactic acid); PLA; poly(lactic acid); PLGA; poly(lactideglycolic acid); PVA; Poly(vinyl alcoh
Evaluation of fasted state human intestinal fluid as apical solvent system in the Caco-2 absorption model and comparison with FaSSIF
Keywords: Caco-2; Permeability; Fasted state human intestinal fluid; FaSSIF; Fraction absorbed in human;
Pharmaceutical nanotechnologyNovel semisolid SNEDDS based on PEG-30-di-(polyhydroxystearate): Progesterone incorporation and in vitro digestion
Keywords: 12-HSA; 12-hydroxystearic acid; CEH; carboxyl ester hydrolase; DPHS; Cithrol® DPHS; DSC; differential scanning calorimetry; ESR; electron spin resonance; FaSSIF; fasted state simulated intestinal fluid; FeSSIF; fed state simulated Intestinal fluid; FTIR;
Fasted-State Simulated Intestinal Fluid "FaSSIF-C", a Cholesterol Containing Intestinal Model Medium for In Vitro Drug Delivery Development
Keywords: in vitro models; biorelevant media; drug solubility; lipids; micelle; light-scattering; DLS; SANS; FaSSIF; Caco-2 cells;
Advances in the design of fasted state simulating intestinal fluids: FaSSIF-V3
Keywords: FaSSIF; Fasted state; Human intestinal fluid; Surface tension; Biorelevant media; Solubility; Bile salts; Lysolecithin;
Advances and challenges in PBPK modeling - Analysis of factors contributing to the oral absorption of atazanavir, a poorly soluble weak base
Keywords: API; active pharmaceutical ingredient; ART; antiretroviral therapy; AUC; area under the curve; BCRP; breast cancer resistance protein; BCS; biopharmaceutics classification system; Caco-2; heterogeneous human epithelial colorectal adenocarcinoma cells; Cma
Solubility enhancement of BCS Class II drug by solid phospholipid dispersions: Spray drying versus freeze-drying
Keywords: CXB; celecoxib; FaSSIF; fasted state simulated intestinal fluid; FD; freeze-dried; PBS; phosphate buffer; PB; physical blend; PL; phospholipid (lipoid E80); SD; spray-dried; SPLN; solid phospholipid nanoparticles; Solid phospholipid nanoparticles; Amorpho
Compound selection for development - Is salt formation the ultimate answer? Experiences with an extended concept of the “100 mg approach”
Keywords: DSC; Differential Scanning Calorimetry; DVS; Dynamic Vapor Sorption; FaSSIF; Fasted State Simulating Intestinal Fluid; FeSSIF; Fed State Simulating Intestinal Fluid; (HP)LC; (High Pressure) Liquid Chromatography; ICH; International Conference on Harmoniza
Application of in vitro biopharmaceutical methods in development of immediate release oral dosage forms intended for paediatric patients
Keywords: BCS; Biopharmaceutics classification system; EMA; European Medicines Agency; FaSSIF; Fasted state simulated intestinal fluid; FDA; (United States) Food and Drug Administration; FeSSIF; Fed state simulated intestinal fluid; GI; Gastrointestinal; IVIVR; In
Biorelevant solubility of poorly soluble drugs: Rivaroxaban, furosemide, papaverine and niflumic acid
Keywords: Biorelevant solubility; FaSSIF; FeSSIF; Saturation shake-flask method; Solubilization; Food effect;
Amorphous solid dispersion enhances permeation of poorly soluble ABT-102: True supersaturation vs. apparent solubility enhancement
Keywords: Permeability; Solid dispersion; Solubility; Supersaturation; FaSSIF
Assessment of enzymatic prodrug stability in human, dog and simulated intestinal fluids
Keywords: Enzymatic stability; Prodrug; Human intestinal fluid; Pancreatin; FaSSIF; SDS–PAGE gel
Solvent shift method for anti-precipitant screening of poorly soluble drugs using biorelevant medium and dimethyl sulfoxide
Keywords: Anti-precipitant; FaSSIF; HPMC-AS; Itraconazole; High throughput screening; DMSO
Solvent-Mediated Solid Phase Transformations of cArbamazepine: Effects of Simulated Intestinal Fluid and Fasted State Simulated Intestinal Fluid
Keywords: carbamazepine; polymorphs; solvates/hydrates; Raman spectroscopy; dissolution rate; SIF; FaSSIF;