Biorelevant solubility of poorly soluble drugs: Rivaroxaban, furosemide, papaverine and niflumic acid

- The biorelevant solubility of compounds with different acid-base properties were measured using validated saturation shake-flask method.
- The precise evaluation of the ionization/solubilization effect on BRM solubility is done.
- The biorelevant solubility of ampholyte niflumic acid is explained with the microspeciation of the molecule.
- The relationship between the administration and the biorelevant solubility of drugs is discussed.