Keywords: α-CGRP; alpha-calcitonin gene related peptide; Ang; angiopoietin; AE2; anion exchanger 2; ADP; adenosine diphosphate; ADPKD; autosomal dominant polycystic kidney disease; ATP; adenosine triphosphate; ASBT; sodium-dependent bile acid transporter; AQP; aqu
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Keywords: Atherosclerosis; Cardiovascular diseases; Cell cycle; Proliferation; Pulmonary hypertension; Restenosis; Signaling pathway; Vascular smooth muscle cells; ACE; angiotensin converting enzyme; aFGF; acidic FGF; Ang II; angiotensin II; AP-1; activating protei
Keywords: AGBL2; ATP/GTP binding protein-like 2; BMPR1A; Bone morphogenetic protein receptor, type 1A; CLEC3B; C-type lectin domain family 3; C1QTNF1; C1q and tumor necrosis factor related protein1; DDAH1; Dimethylarginine dimethylaminohydrolase 1; DEGs; Differenti
Keywords: D2R; dopamine receptor; cAMP; cyclic adenosine monophosphate; PKA; protein kinase A; DARPP-32; dopamine and cAMP-regulated phosphoprotein; PP1; protein phosphatase 1; MEK; mitogen-activated protein kinase/ERK kinase; ERK; extracellular-signal regulated ki
Keywords: PTP; protein tyrosine phosphatase; PTK; protein tyrosine kinase; LMW-PTP; low molecular weight protein tyrosine phosphatase; LMW-AP; low molecular weight acid phosphatase; ACP1; gene coding for human LMW-PTP; PTP1B; tyrosine-protein phosphatase non-recept
Transcriptome analysis for identification of candidate genes related to sex determination and growth in Charybdis japonica
Keywords: C. japonica; Charybdis japonica; SSRs; simple sequence repeats; ORFs; open reading frames; E1; ubiquitin activating enzyme; E2; ubiquitin conjugating enzyme; E3; ubiquitin ligase; JHE; juvenile hormone esterase; STAT; signal transducer and activator of tr
Ubiquitination and SUMOylation in the chronic inflammatory tumor microenvironment
Keywords: Inflammation-associated cancer; Ubiquitin-proteasome system (UPS); Small ubiquitin-like modifier (SUMO); Tumor microenvironment; Cytokine profile; Transcription factors; 15d-PGJ2; 15-Deoxy-Delta-12,14-prostaglandin J2; AR; androgen receptor; Ala; alanine;
Global gene expression analysis of knockdown Triosephosphate isomerase (TPI) gene in human gastric cancer cell line MGC-803
Keywords: TPI; triosephosphate isomerase; GC; gastric cancer; DEGs; differentially expressed genes; PPI; protein-protein interaction; G3P; glyceraldehyde 3-phosphate; DHAP; dihydroxyacetone phosphate; RT-qPCR; reverse transcription-quantitative polymerase chain rea
The Transcription Factor ETV5 Mediates BRAFV600E-Induced Proliferation and TWIST1 Expression in Papillary Thyroid Cancer Cells
Keywords: AKT; protein kinase B (or PKB); ATC; anaplastic thyroid carcinoma; BRAF; v-Raf murine sarcoma viral oncogene homolog B (or B-RAF); EMT; epithelial-mesenchymal transition; ERK; extracellular signal-regulated kinase (or mitogen-activated protein kinase 1);
Manganese exposure: Linking down-regulation of miRNA-7 and miRNA-433 with α-synuclein overexpression and risk of idiopathic Parkinson's disease
Keywords: BCL2; B-cell CLL/lymphoma 2; CCND1; cyclin D1; CCNE1; cyclin E1; CRKL; V-Crk avian sarcoma virus CT10 oncogene homolog-like; FGF20; fibroblast growth factor 20; FGF7; fibroblast growth factor 7; FOXO1; forkhead box protein O1A; GRB2; growth factor recepto
Ca2+ signaling and Src-kinases-controlled cellular functions
Keywords: Ca2+ channels; Cell signaling; Phosphatases; Receptors; Src-family kinases; A23187; 5-(methylamino)-2-({(2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl]-1,7-dioxaspiro[5.5]undec-2-yl}methyl)-1,3-benzoxazole-4-carboxyli
Oncogenic mutations of PIK3CA and HRAS in carcinoma of cervix in South Indian women
Keywords: Oncogenic mutations; Cervical cancer; Peripheral blood; PCR-CTPP method; PIK3CA; Phosphatidylinositol-4,5-Bisphosphate; 3-Kinase Catalytic Subunit Alpha; HRAS; Harvey rat sarcoma viral oncogene homolog; EGF; Epidermal Growth Factor; PDGF; Platelet Derived
TCR crosslinking promotes Crk adaptor protein binding to tyrosine-phosphorylated CD3ζ chain
Keywords: T cell activation; TCR/CD3 crosslinking; CD3ζ chain; Crk adaptor proteins; Tyrosine phosphorylation; Signal transduction; C3G; Crk SH3 domain-binding guanine nucleotide-releasing factor; Crk; CT10 (chicken tumor virus number 10) regulator of kinase; CrkL
α-Lipoic acid inhibits human lung cancer cell proliferation through Grb2-mediated EGFR downregulation
Keywords: α-lipoic acid; Cell proliferation; NSCLC; Grb2; EGFR;
MiR-200a modulates TGF-β1-induced endothelial-to-mesenchymal shift via suppression of GRB2 in HAECs
Keywords: MicroRNA; miR-200a; Endothelial-mesenchymal transition; Fibrosis; TGF-β1; GRB2;
Gln223Arg polymorphism in the Caucasian population and Pro1019Pro polymorphism in the Chinese population are risk factors for OSAS: An updated meta-analysis of 1159 subjects
Keywords: ACC; acetyl-CoA carboxylase; AMPK; 5â² adenosine monophosphate-activated protein kinase; CI; confidence intervals; CNKI; Chinese National Knowledge Infrastructure; Grb2; growth factor receptor-bound protein 2; HWE; Hardy-Weinberg equilibrium; IRS; insu
Grb2 regulates the proliferation of hematopoietic stem and progenitors cells
Keywords: Hematopoietic stem cells; Hematopoiesis; Self-renewal; Signal Transduction; Bone marrow transplantation; Grb2;
Enhanced antitumor activity of gemcitabine by polysaccharide-induced NK cell activation and immune cytotoxicity reduction in vitro/vivo
Keywords: SEP; A polysaccharide isolated from Strongylocentrotus nudus egg; TLR; toll-like receptor; NKG2D; natural-killer group 2 member D; DAP10; DNAX-associated protein 10; Akt; protein kinase B; MICA; MHC class I-related chain A; sMICA; soluble MHC class I-rela
A Highly Diverse and Functional Naïve Ubiquitin Variant Library for Generation of Intracellular Affinity Reagents
Keywords: Ubv; ubiquitin variant; Ub; ubiquitin; wt; wild-type; EGFR; epidermal growth factor receptor; EGF; epidermal growth factor; Her3; human epidermal growth factor receptor 3; NRG; neuregulin; Grb2; growth factor receptor-bound protein 2; GST; glutathione S-t
Imaging flow cytometry and GST pulldown assays provide new insights into channel catfish leukocyte immune-type receptor-mediated phagocytic pathways
Keywords: Phagocytosis; Immunoregulatory receptors; Intracellular signaling; Actin polymerization machinery; Imaging flow cytometry; Innate immunity; Channel catfish; Leukocyte immune-type receptors; IpLITR; channel catfish leukocyte immune-type receptor; CYT; cyto
Systematic Identification of Oncogenic EGFR Interaction Partners
Keywords: EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; ERK; extracellular signal-regulated kinase; GFP; green fluorescent protein; Grb2; growth factor receptor-bound protein 2; SH; Src homology; MAPK; mitogen-activated protein kinase; TK; t
The multi-site docking protein Gab1 is constitutively phosphorylated independent from its recruitment to the plasma membrane in Jak2-V617F-positive cells and mediates proliferation of human erythroleukaemia cells
Keywords: AEBSF; 4-(2-aminoethyl)-benzolsulfonylfluorid; DMEM; Dulbecco's modified Eagle's medium; EGFR; epidermal growth factor receptor; Epo; erythropoietin; EpoR; erythropoietin receptor; Erk; extracellular signal regulated kinase; FCS; fetal calf serum; Gab1; G
The roles of subcellularly located EGFR in autophagy
Keywords: AMPK; AMP-activated protein kinase; ATG; autophagy-related; BCL2; B-cell lymphoma 2; BCL2L1; BCL2 like 1; BNIP3; BCL2/Adenovirus E1B-binding protein Nip3; CME; clathrin-mediated endocytosis; cytoSTAT3; cytoplasmic STAT3; Dsbs; double strand breaks; ECD; e
Up-regulation of the active form of small GTPase Rab13 promotes macroautophagy in vascular endothelial cells
Keywords: AMPK; AMP-activated protein kinase; AO; acridine orange; AVOs; acidic vesicular organelles; FGF-2; fibroblast growth factor 2; Grb2; growth factor receptor binding protein 2; Rab13; Ras-related protein in brain 13; HA; hemagglutinin; HRP; Horseradish pero
Src-family tyrosine kinases and the Ca2Â + signal
Keywords: 5-HT6; serotonin receptor 6; A23187; 5-(methylamino)-2-({(2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl]-1,7-dioxaspiro[5.5]undec-2-yl}methyl)-1,3-benzoxazole-4-carboxylic acid; ADPR; ADP-ribose; AMPA; α-amino-3-hydr
Modifications to the composition of the hyphal outer layer of Aspergillus fumigatus modulates HUVEC proteins related to inflammatory and stress responses
Keywords: AiP; programed cell death 6-interacting protein; AKT; protein kinase B; ASK1; mitogen-activated protein kinase 5; BAD; BLC2-associated agonist of cell death; BAX; BCL2-associated X protein; CD-142; tissue factor; cFOS; FBJ Murine osteosarcoma viral oncoge
Systemic study of a natural feedback loop in Huntington's disease at the onset of neurodegeneration
Keywords: Grb2; Growth factor receptor bound protein 2; Htt; Huntingtin; mHtt; mutant Huntingtin; FoxD3; Forkhead box D3; Sos-1; son of sevenless homolog 1; Gab1; Grb2 associated binding protein 1; MAPK; mitogen activated protein kinase; ERK; Extra cellular signal
miR-411-5p inhibits proliferation and metastasis of breast cancer cell via targeting GRB2
Keywords: miR-411-5p; GRB2; Breast cancer; Proliferation; Metastasis;
Down-regulation of brain-derived neurotrophic factor and its signaling components in the brain tissues of scrapie experimental animals
Keywords: Prion diseases; Scrapie; BDNF; TrkB; GRB2; p75NTR;
Bromodomain containing protein represses the Ras/Raf/MEK/ERK pathway to attenuate human hepatoma cell proliferation during HCV infection
Keywords: BRCA1; breast cancer 1; BRD7; bromodomain containing 7; CCK8; cell counting kit 8; c-Fos; cellular Fos proto-oncogene; CHX; cycloheximide; c-Myc; cellular Myc proto-oncogene; CRC; colorectal cancer; EOC; epithelial ovarian carcinoma; GAPDH; glyceraldehyde
Novel miR-5582-5p functions as a tumor suppressor by inducing apoptosis and cell cycle arrest in cancer cells through direct targeting of GAB1, SHC1, and CDK2
Keywords: CRC; colorectal cancer; miRNA; microRNA; MTS; (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium); GAB1; GRB2-associated binding protein 1; SHC1; SRC homology 2 domain containing 1; GRB2; growth factor receptor-bound
Cell confluence induces switching from proliferation to migratory signaling by site-selective phosphorylation of PDGF receptors on lipid raft platforms
Keywords: DAG; diacylglycerol; GM1; monosialotetrahexosylganglioside; GRB2; growth factor receptor binding protein-2; IP3; inositol 1,4,5-trisphosphate; PDGF; platelet-derived growth factor; PDGF-BB; homodimer of the B isoform of platelet derived growth factor); PD
Immunoreceptors on neutrophils
Keywords: ADCC; antibody-dependent cellular cytotoxicity; ANCAs; anti-neutrophil autoantibodies; Btk; Bruton's tyrosine kinase; DAG; diacyl-glycerol; DAP12; DNAX activation protein of 12Â kDa; ERK; extracellular signal-regulated kinase; fMLP; N-Formylmethionine-leu
EGFR-GRB2 Protein Colocalization Is a Prognostic Factor Unrelated to Overall EGFR Expression or EGFR Mutation in Lung Adenocarcinoma
Keywords: EGFR; GRB2; Proximity ligation assay; NSCLC; Adenocarcinoma; Quantitative immunofluorescence;
How B cells remember? A sophisticated cytoplasmic tail of mIgG is pivotal for the enhanced transmembrane signaling of IgG-switched memory B cells
Keywords: B cell receptor; Memory B cell; mIgG cytoplasmic tail; Grb2; SAP97; CD22;
ShcC proteins: Brain aging and beyond
Keywords: ShcC adaptor proteins; Signaling; Aging; Brain ischemia; Brain tumors; Immunity; Aβ; beta-amyloid; AD; Alzheimer's disease; Akt; protein kinase B (PKB); ALK; anaplastic lymphoma kinase (receptor tyrosine kinase); APP; alpha-amyloid precursor protein; ARD
Regions outside of conserved PxxPxR motifs drive the high affinity interaction of GRB2 with SH3 domain ligands
Keywords: DLS; dynamic light scattering; ITC; isothermal titration calorimetry; PRR; proline rich region; TIRF; total internal reflection fluorescence; SH3 domains; GRB2; SOS1; CBL; Signal transduction;
Zinc promotes proliferation and activation of myogenic cells via the PI3K/Akt and ERK signaling cascade
Keywords: IR; insulin receptor; IGFR; insulin-like growth factor receptor; IRS-1; insulin receptor substrate-1; PI3K; phosphoinositide 3-kinase; mTOR; mammalian target of rapamycin; Grb2; growth factor receptor-bound protein 2; FGF2; fibroblast growth factor 2; DTP
Modulation of TCR responsiveness by the Grb2-family adaptor, Gads
Keywords: DAG; diacylglycerolDSB, double strand break; Gads; Grb2-related adaptor downstream of Shc; Indel; insertion and deletion mutation; GFP; green fluorescent protein; Grap; Grb2-related adaptor protein; Grb2; growth factor receptor-bound 2; IRES; internal rib
The different expression profiles of microRNAs in elderly and young human dental pulp and the role of miR-433 in human dental pulp cells
Keywords: Human dental pulp cell; Senescence; MicroRNAs; GRB2; RAS-MAPK signaling pathways;
MAPK-induced Gab1 translocation to the plasma membrane depends on a regulated intramolecular switch
Keywords: Crk; CT10 regulator of kinase; CRKL; Crk-like protein; ERK; extracellular signal regulated kinase; FCS; foetal calf serum; Gab1; Grb2-associated binder 1; Grb2; growth factor receptor bound protein 2; IL-6; interleukin-6; JAK; Janus kinase; HEK; human emb
Mutant huntingtin replaces Gab1 and interacts with C-terminal SH3 domain of growth factor receptor binding protein 2 (Grb2)
Keywords: HD; Huntington's disease; Htt; huntingtin; Grb2; growth factor receptor binding protein 2; Sos1; Son of Sevenless homolog 1; Gab1; Grb2 associated binding protein 1; SH2; Src homology 2; SH3; Src homology 3; N-SH3; N-terminal SH3 domain; C-SH3; C-terminal
Activated PLC-γ1 is catalytically induced at LAT but activated PLC-γ1 is localized at both LAT- and TCR-containing complexes
Keywords: PLC-γ1; phospholipase C-γ1; TCR; T cell receptor; IP3; inositol 1,4,5 phosphate; DAG; diacylglycerol; TCR; LAT; PLC-γ1; Phosphorylation kinetics; Grb2;
Transcriptomics profiling and steroid production in mummichog (Fundulus heteroclitus) testes after treatment with 5α-dihydrotestosterone
Keywords: 11KT; 11-ketotestosterone; ABCC2; ATP-binding cassette, sub-family C (CFTR/MRP), member 2; ABCC3; ATP-binding cassette, sub-family C (CFTR/MRP), member 3; ABCG8; ATP-binding cassette, sub-family G (WHITE), member 8; ACY1; aminoacylase 1; ADAR; adenosine d
Novel inhibitors of a Grb2 SH3C domain interaction identified by a virtual screen
Keywords: SH3 Domain; Grb2; Gab2; Virtual screening; Protein-protein interaction; Inhibitors;
Structural landscape of the proline-rich domain of Sos1 nucleotide exchange factor
Keywords: Abi1; Abl interactor 1; CD; Circular dichroism; Cdc25; Cell cycle division 25; DH; Dbl homology; DLS; Dynamic light scattering; EGFR; Epidermal growth factor receptor; Eps8; EGFR kinase substrate 8; Grb2; Growth factor receptor binder 2; GuHCl; Guanidine
Peptide microarrays to probe for competition for binding sites in a protein interaction network
Keywords: Peptide microarrays; GRB2; SH2/SH3 domains; Dissociation constant; NanoLC-MS/MS; Fluorescence correlation spectroscopy;
Activation of integrin β1-focal adhesion kinase-RasGTP pathway plays a critical role in TGF beta1-induced podocyte injury
Keywords: TGFβ1; Integrin; FAK; Grb2; GTP-Ras; Podocyte apoptosis;
A perspective on non-catalytic Src homology (SH) adaptor signalling proteins
Keywords: Src Homology domain; Adaptor protein; Signal transduction; CrkL; Grb2; Nck
Biophysical studies with AICD-47 reveal unique binding behavior characteristic of an unfolded domain
Keywords: APP; amyloid precursor's protein; AICD; APP-intracellular C-terminal domain; AD; Alzheimer's disease; SH2; Src homology 2; PTR and pY; phosphorylated tyrosine; IUD; intrinsically unstructured domain; Grb2; growth factor receptor binding protein 2, TFE