Keywords: Aflatoxin; Genotoxicity; H2AX; Metabolism; DNA damage;
مقالات ISI (ترجمه نشده)
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Keywords: DNA damage; Comet; H2AX; Host cell reactivation; DNA repair; DNA damage response; Precision medicine;
Keywords: 3-MA; 3-methyladenine; Asc; ascorbate; ATM; ataxia telangiectasia mutated; ATP; adenosine triphosphate; BRAF; murine sarcoma viral oncogene homolog B; Cat; catalase; Chk2; checkpoint kinase 2; CQ; chloroquine; Cys-SO3H; cysteine S-sulfate; DHA; dehydroasc
Keywords: Bystander effect; DNA damage response; ATM; H2AX;
Keywords: Telomere; imetelstat; GRN163L; atypical teratoid/rhabdoid tumor; H2AX; DNA damage
Keywords: Bleomycin; Glioblastoma; Bystander response; Micronucleus; H2AX; Cell cycle kinetics;
Selenium unmasks protective iron armor: A possible defense against cutaneous inflammation and cancer
Keywords: GPX4; Glutathione Peroxidase 4; System XC; Cystine/Glutamate Antiporter-System XC; TNFα; Tumor necrosis factor alpha; VEGF; Vascular endothelial growth factor; S1P; Sphingosine-1 phosphate; IL-22; Interleukin-22; Trx1; Thioredoxin; Txnrd1; Thioredoxin re
The possible DNA damage induced by environmental organic compounds: The case of Nonylphenol
Keywords: DNA damage; H2AX; Oxidative stress; Genotoxicity; Nonylphenol;
Resveratrol represses estrogen-induced mammary carcinogenesis through NRF2-UGT1A8-estrogen metabolic axis activation
Keywords: 2-MeOE1/E2; 4-MeOE1/E2, methoxyestrogens; 2-OHE1/E2; 4-OHE1/E2, hydroxyestrogens; 53BP1; tumor protein p53 binding protein 1; DMBA; 7,12-dimethylbenz(a)anthracene; DSBs; DNA double-strand breaks; E1; estrone; E2; estradiol; E2-3G; E2-3-glucuronide; E2-17G
JNK1 as a signaling node in VDR-BRAF induction of cell death in AML
Keywords: AP-1; Activator protein 1, c-Jun and dimerization partners; AKT; Serine/threonine protein kinase B (PKB); AML; Acute myeloid leukemia; AraC; Cytarabine/Arabinocytosine; ASK1; Apoptosis signal regulating kinase 1; BCL2; B-cell lymphoma 2; BIM; Bcl-2-like p
Pregnane X receptor regulates the AhR/Cyp1A1 pathway and protects liver cells from benzo-[α]-pyrene-induced DNA damage
Keywords: PXR; pregnane X receptor; AhR; aryl hydrocarbon receptor; DRE; dioxin response element; BaP; benzo[a]pyrene; RIF; rifampicin; H2Ax; histone 2Ax; CAR; constitutive androstane receptor; FXR; farnesoid X receptor; CYP450; cytochrome P450; EROD; 7-ethoxyresor
SVCT-2 determines the sensitivity to ascorbate-induced cell death in cholangiocarcinoma cell lines and patient derived xenografts
Keywords: Ascorbic acid; Cholangiocarcinoma; ROS; SVCT-2; CC; cholangiocarcinoma; AA; ascorbic acid; ROS; reactive oxygen species; SVCT; sodium-dependent vitamin C transporter; NAC; N-acetyl-l-cysteine; CI; combination index; H2AX; histone 2AX; AMPK; adenosine mono
Original ArticleDoxorubicin anti-tumor mechanisms include Hsp60 post-translational modifications leading to the Hsp60/p53 complex dissociation and instauration of replicative senescence
Keywords: Doxorubicin; Hsp60; Acetylation; Ubiquitination; p53; Replicative senescence; DMSO; dimethylsulfoxide; ELISA; enzyme linked immunosorbent assay; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; GUSB; betaglucuronidase; HDAC; histone deacetylases; H2AX; H2
Histone H2AX and the small RNA pathway modulate both non-homologous end-joining and homologous recombination in plants
Keywords: Zinc finger nuclease (ZFN); DNA double-strand break (DSB) repair; H2AX; Small RNA; Arabidopsis thaliana;
Common and unique genetic interactions of the poly(ADP-ribose) polymerases PARP1 and PARP2 with DNA double-strand break repair pathways
Keywords: PARP1; PARP2; H2AX; DNA-PKcs; Ku80; Double-strand breaks;
Genetic modification of H2AX renders mesenchymal stromal cell-derived dopamine neurons more resistant to DNA damage and subsequent apoptosis
Keywords: DNA damage; H2AX; lentivirus infection; mesenchymal stromal cells; Parkinson's disease;
House dust mite-induced asthma causes oxidative damage and DNA double-strand breaks in the lungs
Keywords: House dust mite; asthma; oxidative stress; DNA double-strand breaks; BEAS-2B; cell death; DNA repair; NU7441; AHR; Airway hyperresponsiveness; ATM; Ataxia-telangiectasia mutated; BAL; Bronchoalveolar lavage; CC10; Club cell 10Â kDa protein; DCFH-DA; 2,7-D
Changes in the expression of DNA double strand break repair genes in primordial follicles from immature and aged rats
Keywords: BRCA1; DNA repair; H2AX; ovarian aging; primordial follicles; RAD51
Encapsulation of temozolomide in a tumor-targeting nanocomplex enhances anti-cancer efficacy and reduces toxicity in a mouse model of glioblastoma
Keywords: BBB; blood-brain barrier; CSC; cancer stem cell; GBM; glioblastoma multiforme; H2AX; H2A histone family, member X; scL; tumor-targeted liposome nanocomplex; TMZ; temozolomide; scL-TMZ; scL-encapsulated TMZ nanocomplex; TfR; transferrin receptor; TfRscFv
Curcumin inhibits PhIP induced cytotoxicity in breast epithelial cells through multiple molecular targets
Keywords: Phytochemicals; Cancer prevention; Reactive oxygen species; DNA damage; DNA adduct; Heterocyclic amines; AOPI; acridine orange/propidium iodide; BRCA-1; breast cancer 1 early onset; CAT; catalase; DCFDA; 2â²,7â²-dichlorodihydrofluorescein diacetate; DEP
Resveratrol induces DNA damage in colon cancer cells by poisoning topoisomerase II and activates the ATM kinase to trigger p53-dependent apoptosis
Keywords: ab; antibody; ATM; ataxia telangiectasia mutated; ATR; ataxia telangiectasia and rad3 related; DAPI; 4â²,6-diamidino-2-phenylindole; DNA-PK; DNA-dependent protein kinase; DOX; doxorubicin; ERK1/2; extracellular signal-regulated kinase 1/2; H2AX; histone
Activation of H2AX and ATM in varicella-zoster virus (VZV)-infected cells is associated with expression of specific VZV genes
Keywords: Varicella-zoster virus; ATM; H2AX; DNA damage; Herpesvirus; Herpes simplex virus;
Dub3 controls DNA damage signalling by direct deubiquitination of H2AX
Keywords: Deubiquitylating enzyme (Dub); H2AX; RNF8; RNF168; Ubiquitin hydrolase; ETP; etoposide; CI; catalytic inactive; DDR; DNA damage response; Dub; deubiquitylating enzyme; HU; hydroxyurea; IR; ionizing radiation; WT; wild type;
DNA damage response (DDR) via NKX3.1 expression in prostate cells
Keywords: H2AX; ATM phosphorylation; Irinotecan (CPT-11); Doxorubicin; Etoposide;
Oxidative stress and hepatic Nox proteins in chronic hepatitis C and hepatocellular carcinoma
Keywords: 8-OHdG; 8-hydroxydeoxyguanosine; ALT; alanine aminotransferase; AP-1; activator protein 1; BHA; butylated hydroxyanisole; CD81; cluster of differentiation 81; CXCL10; C-X-C motif chemokine 10; CYP; cytochrome P450; DCF; dihydrodichlorocarboxyfluorescein;
Arf and p53 act as guardians of a quiescent cellular state by protecting against immortalization of cells with stable genomes
Keywords: CTU; camptothecin; HU; hydroxyurea; KO; knockout; MEFs; mouse embryonic fibroblasts; WT; wild-type; Arf; Genome stability; H2AX; p53; Quiescent state;
Studying the cerebellar DNA damage response in the tissue culture dish
Keywords: 53BP1; p53 binding protein 1; AOA1/2; ataxia with oculomotor apraxia type 1; A-T; ataxia-telangiectasia; A-TLD; ataxia-telangiectasia-like disorder/disease; ATM; ataxia-telangiectasia, mutated; ATR; ATM- and Rad3-related protein kinase; CaBP; calbindin pr
Ex vivo human skin experiments for the evaluation of safety of new cold atmospheric plasma devices
Keywords: AFM, Atomic Force Microscopy; CAP, Cold Atmospheric Plasma; DBD, Dielectric Barrier Discharge; SMD, Surface Micro-Discharge; UV, UltravioletPlasma medicine; Cold atmospheric plasma; Plasma; H2AX; Chronic wounds; Clinical trial
Double strand break repair functions of histone H2AX
Keywords: Mammalian DSB repair; H2AX; MDC1; 53BP1; BRCA1; Mre11/Rad50/Nbs1; Histone code; Homologous recombination; Non-homologous end joining; Single strand annealing
Co-mutation of histone H2AX S139A with Y142A rescues Y142A-induced ionising radiation sensitivity
Keywords: H2AX; Y142; S139; DSB; IR; 53BP1DSB, DNA double strand break; IR, ionising radiation; WSTF, Williams–Beuren syndrome transcription factor kinase; IRIF, ionising radiation induced foci; WT, Wild type; F, phenylalanine; W, tryptophan; A, alanine; Y, tyrosin
Comparative potency approach based on H2AX assay for estimating the genotoxicity of polycyclic aromatic hydrocarbons
Keywords: Polycyclic aromatic hydrocarbons; Modelization; Toxic Equivalent Factor; Genotoxicity; H2AX; HepG2; LS-174T
Specific recognition of phosphorylated tail of H2AX by the tandem BRCT domains of MCPH1 revealed by complex structure
Keywords: BRCT; BRCA1 C-terminal domain; IRIF; Ionizing Radiation-Induced Foci; DSBs; double-stranded DNA breaks sites; DDR; DNA damage response; H2AX; histone 2A variant X; hTERT; human telomerase reverse transcriptase; SWI-SNF; switching defective/sucrose non-f
Reconstitution of the cellular response to DNA damage in vitro using damage-activated extracts from mammalian cells
Keywords: DNA damage response; Cell free system; H2AX; Double strand breaks; Cell cycle; Assay development; In vitro drug screening
Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: The molecular choreography
Keywords: 53BP1; Tp53 binding protein 1; 9-1-1; RAD9-RAD1-HUS1 checkpoint clamp complex; a.a.; amino acid; ACF1; ATP-utilizing chromatin assembly and remodeling factor 1; ALC1; amplified in liver cancer 1; APLF/PALF; aprataxin and PNKP-like factor; Aprataxi
Assessing 'radiosensitivity' with kinetic profiles of γ-H2AX, 53BP1 and BRCA1 foci
Keywords: Radiosensitivity; BRCA1; H2AX; Foci; Kinetics;
Expression of γ-H2AX in endometrial carcinomas: An immunohistochemical study with p53
Keywords: Endometrial cancer; Immunohistochemistry; H2AX; p53; γ-H2AX;
The poly(ADP-Ribose) polymerase inhibitor ABT-888 reduces radiation-induced nuclear EGFR and augments head and neck tumor response to radiotherapy
Keywords: Head and neck cancer; PARP; ABT-888; EGFR; Biomarker; H2AX; DNA damage; Nuclear import; DNA repair; Non-homologous end-joining (NHEJ); Radiation;
Gammaherpesvirus gene expression and DNA synthesis are facilitated by viral protein kinase and histone variant H2AX
Keywords: Gammaherpesvirus; DNA damage response; H2AX; Gammaherpesvirus protein kinase
Benzo[a]pyrene induces complex H2AX phosphorylation patterns by multiple kinases including ATM, ATR, and DNA-PK
Keywords: H2AX; DNA damage; Benzo[a]pyrene; Caffeine; Phosphatidylinositol 3-kinase
Acetylation of H2AX on lysine 36 plays a key role in the DNA double-strand break repair pathway
Keywords: DSB; DNA double-strand break; IR; ionizing radiation; HAT; histone acetyltransferase; HDAC; histone deacetylase; H2AXK36Ac; H2AX acetylated on lysine 36; TSA; trichostatin A; H2AX; Acetylation; Chromatin; DNA double-strand break; Histone acetyltransferase
Expression of genes coding for histone variants and histone-associated proteins in pluripotent stem cells and mouse preimplantation embryos
Keywords: Mouse; Preimplantation embryo; Embryonic stem cells; Histone; Histone variant; H2A; H2AZ; H2AX; H2AJ; H2AY1; H2AY2; H2A.Bbd; H3.1; H3.2; H3.3A; H3.3B; CENPA; SWI/SNF; CAF-1
Enzastaurin induces H2AX phosphorylation to regulate apoptosis via MAPK signalling in malignant glioma cells
Keywords: Enzastaurin; PKC; H2AX; Chk2; Apoptosis; Glioma;
Focus on histone variant H2AX: To be or not to be
Keywords: H2AX; MRE11/RAD50/NBS1; DNA damage; DNA repair; Non-homologous end-joining; Homologous recombination;
Use of the γH2AX assay for assessing the genotoxicity of polycyclic aromatic hydrocarbons in human cell lines
Keywords: Polycyclic aromatic hydrocarbons; Metabolism; Genotoxicity; H2AX; HepG2
Conserved gammaherpesvirus kinase and histone variant H2AX facilitate gammaherpesvirus latency in vivo
Keywords: gammaherpesvirus; herpesvirus protein kinase; latency; H2AX; DNA damage response;
Sirt1 physically interacts with Tip60 and negatively regulates Tip60-mediated acetylation of H2AX
Keywords: DDR, DNA damage response; DSB, DNA double-strand break; IRIF, irradiation-induced foci; γIR, γ-ray irradiationSirt1; Tip60; H2AX; IR-induced foci (IRIF)
H2AX phosphorylation in A549 cells induced by the bulky and stable DNA adducts of benzo[a]pyrene and dibenzo[a,l]pyrene diol epoxides
Keywords: PAH; Diol epoxide; BPDE; DBPDE; DNA adducts; H2AX
H2AX phosphorylation as a genotoxicity endpoint
Keywords: H2AX; Phosphorylation; Comet; Micronucleus; Assay; Genotoxicity
γH2AX: A potential DNA damage response biomarker for assessing toxicological risk of tobacco products
Keywords: Tobacco smoke; H2AX; Double strand breaks; DNA damage
hCCR4/cNOT6 targets DNA-damage response proteins
Keywords: Chk2; Cisplatin; H2AX; CCR4/CNOT complex