Keywords: Carvacrol; Melanogenesis; B16F10 cells; IBMX;
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Keywords: Obesity; Polyphenol; Adipogenesis; PPARγ; Lipid; Rice; ABTS; 2,2â²-azino-bis-3-ethylbenzothiazoline-6-sulphonic acid; ACO; acyl-CoA oxidase; CYP4A10; cytochrome P450; AMPK; AMP-activated protein kinase; AT; adipose tissue; C/EBPâ; CAAT/enhancer-bindin
Keywords: Phosphodiesterase-6; Inhibitor; Inhibition constant; Retina; Photoreceptors; Ex vivo electroretinography; A; activation coefficient; cAMP; adenosine 3â²,5â² cyclic monophosphate; cGMP; guanosine 3â²,5â² cyclic monophosphate; CNG channel; cyclic nucleo
Keywords: NE; neuroendocrine; NED; neuroendocrine differentiation; NSCLC; non-small cell lung cancer; SCLC; small cell lung cancer; LCNEC; large-cell neuroendocrine carcinoma; PCa; prostate cancer; NSE; neuron specific enolase; CgA; choromogranin A; Syn; synaptophy
Keywords: BCA; Bicinchoninic acid; CK; Creatine kinase; CP; Creatine phosphate; DEAE; Diethylaminoethanol; DEA/NO; 2,2-Diethyl-1-nitroso-oxyhydrazine; DTPA; Diethylenetriaminepentaacetic acid; DTT; Dithiothreitol; FPLC; Fast protein liquid chromatography; GSNO; S-n
Keywords: Brimonidine; Phospholipidosis; α2 adrenergic agonist; α2 adrenergic antagonist; Meibomian gland dysfunction; Dry eye disease; phosphoinositide 3-kinase-protein kinase B; AKT; bovine pituitary extract; BPE; cationic amphiphilic drug; CAD; adenosine 3,5-c
Keywords: AMP-PNP; adenosine 5â²- (β,γ-imido)triphosphate; BSA; bovine albumin; [Ca2+]i; cytosolic free Ca2+ concentration; cAMP; adenosine cyclic 3â²,5â²-monophosphate; CMP; cytidine 5â²-monophosphate; CREB; cAMP response element binding protein; DMEM; Dulbe
Keywords: cAMP; 3â²,5â²-cyclic adenosine monophosphate; β-AR; β-adrenergic receptor; cGMP; 3â²,5â²-cyclic guanosine monophosphate; FRET; Förster resonance energy transfer; IBMX; 3-isobutyl-1-methylxanthine; ISO; isoproterenol; PDE; phosphodiesterase; SICM; s
Keywords: ANOVA; analysis of variance; BSA; bovine serum albumin; CD; Crohn's disease; ChgA; Chromogranin A; CM; conditioned medium; DAPI; 4â²,6-diamidino-2-phenylindole; DMEM; Dulbecco's modified Eagle's medium; DSS; dextran sodium sulfate; ECM; extracellular mat
Keywords: AD; Alzheimer's disease; cAMP; cyclic adenosine monophosphate; CB1R; Cannabinoid receptor 1; CNS; central nervous system; co-IP; co-immunoprecipitation; Cy3; cyanine 3; D2R; dopamine receptor 2; ERK1/2; extracellular signal-regulated kinase 1/2; FITC; f
Keywords: ANP; atrial natriuretic peptide; BKCa; large-conductance Ca2Â + activated potassium channels; cAMP; cyclic adenosine 3,5â²-monophosphate; CNG; cyclic nucleotide-gated; cGMP; cyclic guanosine 3,5â²-monophosphate; HUASMC; human umbilical artery smooth mus
Keywords: Ach; acetylcholine (Ach); Ad; adrenaline; AKAP; A kinase anchoring protein; Ano1; anoctamin-1 Ca2 +-activated Clâ channel encoded by the ANO1 gene; α-SMA; α-smooth muscle actin; ASMCs; atypical smooth muscle cells; eYFP; enhanced-yellow fluorescent p
Keywords: ACTH; adrenocorticotropin; ACTH-R; adrenocorticotropin receptor; ActRI; activin type-I receptor; ActRII; activin type-II receptor; ALK; activin receptor-like kinase; AngII; angiotensin II; AT1R; Ang II type 1 receptor; BMP; bone morphogenetic protein; BMP
Keywords: GluOC; uncarboxylated osteocalcin; GlaOC; γ-carboxylated osteocalcin; PKA; protein kinase A; ERK; extracellular signal-regulated kinase; PPAR; peroxisome proliferator-activated receptor; GLP-1; glucagon-like peptide-1; gWAT; gonadal white adipose tissue;
Keywords: adipose-derived stem cells; ASCs; atomic force microscopy; AFM; basic fibroblast growth factors; bFGFs; body mass index; BMI; bone morphogenetic protein; BMP; brown adipose tissue; BAT; CCAAT/enhancer-binding protein; C/EBP; cyclic adenosine monophosphate
Keywords: cNMPs; Nucleotidyl cyclases; Phosphodiesterases; Protein kinases; Bacterial toxins; Second messengers; AC; adenylyl cyclase; cAMP; adenosine 3â²,5â²-cyclic monophosphate; CC; cytidylyl cyclase; cCMP; cytidine 3â²,5â²-cyclic monophosphate; cGMP; guanos
Keywords: dNTP; deoxynucleotide triphosphate; EDTA; ethylenediaminetetraacetic acid; EPO; erythropoietin; EPOR; erythropoietin receptor; FBS; fetal bovine serum; FITC; fluorescein isothiocyanate; H2O2; hydrogen peroxide; hAT-MSCs; human adipose tissue derived mesen
Keywords: ADP; adenosine 5-diphosphate; ELISA; enzyme-linked immunosorbent assay; HPLC; high-performance liquid chromatography; IBMX; 3-isobutyl-1-methylxanthine; ODQ; 1,2,4-oxadiazolo[4,3-a]quinoxalin-1-one; PBS; phosphate-buffered saline; Cigarette smoke; Moist t
Keywords: Early antral follicle; IBMX; IVG duration; Oocyte growth; Pre-IVM;
Keywords: LD; lipid droplet; BAT; brown adipose tissue; scWAT; subcutaneous white adipose tissue; gonWAT; periovarian white adipose tissue; mesWAT; mesenteric white adipose tissue; FAs; fatty acids; TAG; triacylglycerol; IBMX; isobutylmethylxanthine; PKA; protein k
Stereoselective effects of lactate enantiomers on the enhancement of 3T3-L1 adipocyte differentiation
Keywords: Lactic acid; Enantiomer; Enantioselectivity; Adipocyte differentiation; 3T3-L1 preadipocyte; cAMP-response element; CRE; CCAAT/enhancer-binding protein; C/EBP; dexamethasone; DEX; glycerol-3-phosphate dehydrogenase; GPDH; fatty acid synthase; FAS; 3-isobu
2-Formyl-komarovicine promotes adiponectin production in human mesenchymal stem cells through PPARγ partial agonism
Keywords: hBM-MSCs; human bone marrow-derived mesenchymal stem cells; IBMX; isobutylmethylxanthine; IDX; insulin, dexamethasone, IBMX; FABP4; fatty acid binding protein 4; PPAR; peroxisome proliferator-activated receptor; qRT-PCR; quantitative real-time reverse tra
Detection of CFTR function and modulation in primary human nasal cell spheroids
Keywords: ALI; air-liquid interface; ASL; airway surface liquid; BMI; body mass index; cAMP; 3â²,5â²-cyclic adenosine monophosphate; CF; Cystic Fibrosis; CFTR; Cystic Fibrosis Transmembrane Conductance Regulator; CRC; conditional reprogramming culture; ENaC; epit
Effect of gamma irradiation on the anti-oxidant and anti-melanogenic activity of black ginseng extract in B16F10 melanoma cells
Keywords: DPPH; 2,2-diphenyl-1-picrylhydrazyl; ABTS; 2,2â²-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid; FRAP; ferric reducing antioxidant power; AEAC; ascorbic acid equivalent antioxidant capacity; TRP-1; tyrosinase related protein-1; TRP-2; tyrosinase related
Cyanidin-3-O-β-glucoside regulates the activation and the secretion of adipokines from brown adipose tissue and alleviates diet induced fatty liver
Keywords: Cy-3-G; cyanidin-3-O-β-glucoside; BAT; brown adipose tissue; NAFLD; non-alcoholic fatty liver disease; NASH; non-alcoholic steatohepatitis; UCP1; uncoupling protein 1; NGF; nerve growth factor; VEGFA; vascular endothelial growth factor A; PET; positron e
Comparison of ex vivo and in vitro intestinal cystic fibrosis models to measure CFTR-dependent ion channel activity
Keywords: A; amiloride; AUC; area-under-the-curve; cAMP; cyclic AMP; CCH; carbachol; CF; cystic fibrosis; CFTR; cystic fibrosis transmembrane conductance regulator; D; differentiation culture conditions; DMSO; dimethylsulfoxide; ENaC; epithelial sodium channel; FIS
Therapeutic effects of the allosteric protein tyrosine phosphatase 1B inhibitor KY-226 on experimental diabetes and obesity via enhancements in insulin and leptin signaling in mice
Keywords: PTP1B inhibitor; Diabetes; Obesity; Allosteric inhibitor; db/db mouse; EDTA; ethylenediaminetetraacetic acid; FBS; fetal bovine serum; GLUT4; glucose transporter type 4; GPDH; glycerol-3-phosphate dehydrogenase; HbA1c; hemoglobin A1c; HFD; high-fat diet;
Lysophosphatidylcholine and its phosphorothioate analogues potentiate insulin secretion via GPR40 (FFAR1), GPR55 and GPR119 receptors in a different manner
Keywords: Lysophosphatidylcholine (LPC); GPR40 (FFAR1); GPR55; GPR119; Insulin secretion; [Ca2+]i; intracellular calcium ions concentration; cAMP; cyclic AMP; GSIS; glucose-stimulated insulin secretion; GPCR; G protein coupled receptor; IBMX; 3-isobutyl-1-methylxan
Phoenixin-14 stimulates differentiation of 3T3-L1 preadipocytes via cAMP/Epac-dependent mechanism
Keywords: AKT; RAC-alpha serine/threonine-protein kinase; BMI; body mass index; BrdU; 5âbromoâ2â²âdeoxyuridine; cAMP; cyclic adenosine monophosphate; C/ebpβ; CCAAT/enhancer-binding protein beta; Epac; exchange protein directly activated by cAMP; Fabp4; fatt
Involvement of the NO/sGC/cGMP/K+ channels pathway in vascular relaxation evoked by two non-quinazoline α1-adrenoceptor antagonists
Keywords: 4-AP; 4-amynopiridine; AC; adenylyl cyclase; BPH; benign prostatic hyperplasia; COX; cyclooxygenase; DAG; diacylglycerol; EDHF; endothelium-derived hyperpolarizing factor; eNOS; endothelial NO synthase; GLI; glibenclamide; HAEC; human aortic endothelial c
Helix aspersa maxima mucus exhibits antimelanogenic and antitumoral effects against melanoma cells
Keywords: BCA; bicinchoninic acid; BSA; bovine serum albumin; DMEM; Dulbecco's modified Eagle's medium; ECM; extracellular matrix; FBS; fetal bovine serum; Fg; fibrinogen; Fn; fibronectin; IBMX; 3-isobutyl-1-methylxanthine; L-DOPA; L-3,4-dihydroxyphenylalanine;
Selective inhibition of histamine-evoked Ca2+ signals by compartmentalized cAMP in human bronchial airway smooth muscle cells
Keywords: AC; adenylyl cyclase; 2-APB; 2-aminoethoxyphenylborane; ASM; airway smooth muscle; cAMP; 3',5'-cyclic AMP; COPD; chronic obstructive pulmonary disease; [Ca2+]i; intracellular free Ca2+ concentration; DMSO; dimethyl sulfoxide; EC50 (IC50); half-maximally e
NKX6.1 induced pluripotent stem cell reporter lines for isolation and analysis of functionally relevant neuronal and pancreas populations
Keywords: Human induced pluripotent stem cells; NKX6.1; Reporter cell line; Directed differentiation; hiPSC-derived beta cells; EBiSC; European Bank for Induced Pluripotent Stem Cells; FACS; Fluorescence activated cell sorting; GFP; Green fluorescence protein; GSIS
The tamoxifen derivative ridaifen-B is a high affinity selective CB2 receptor inverse agonist exhibiting anti-inflammatory and anti-osteoclastogenic effects
Keywords: Cannabinoid receptors; G-protein coupled receptors; Inverse agonist; Antagonist; Drug action; AC; adenylyl cyclase; CB1R; cannabinoid receptor type 1; CB2R; cannabinoid receptor type 2; CHO; Chinese hamster ovary; CP-55,940; 5-(1,1-dimethylheptyl)-2-[5-hy
N-acetyl cysteine reverts the proinflammatory state induced by cigarette smoke extract in lung Calu-3 cells
Keywords: ATP; adenosine triphosphate; cAMP; 3',5'-cyclic adenosine monophosphate; CF; cystic fibrosis; , cROS; cytoplasmic ROS; CFTR; cystic fibrosis transmembrane conductance regulator; mCx-I-III; mitochondrial NADH-cytochrome c oxidoreductase; COPD; Chronic obst
Immunometabolic regulation by triterpenes of Eucalyptus tereticornis in adipose tissue cell line models
Keywords: Obesity; Inflammation; Adipose tissue; Natural products; Triterpenes; PPARγ; Peroxisome proliferator-activated receptor gamma; C/EBPα; CCAAT-enhancer-binding proteins; IL-6; Interleukin 6; IL-1β; Interleukin 1β; TNFα; Tumoral necrosis factor alpha; M
17β-estradiol potentiates TREK1 channel activity through G protein-coupled estrogen receptor
Keywords: EGFP; enhanced green fluorescent protein; FSK; forskolin; hGPER; human G protein-coupled estrogen receptor; IBMX; 3-Isobutyl-1-methylxanthine; IQR; Interquartile range; mGluR; metabotropic glutamate receptor; PTX; pertussis toxin; hTREK1; human TWIK-relat
Millettia macrophylla (Fabaceae) phenolic fraction prevents differentiation of 3T3-L1 adipocytes and the increased risks of cardiovascular diseases in ovariectomized rats
Keywords: CS; calf serum; DCM; dichloromethane; DMEM; Dulbecco's Modified Eagle Medium; DMSO; dimethylsulfoxide; DEX; dexamethasone; E2V; Estradiol valerate; ER; estrogen receptor; ERT; estrogen replacement therapy; IBMX; 3-isobutyl-1-methylxanthine; PF; phenolic f
Isolation and lipolytic activity of eurycomanone and its epoxy derivative from Eurycoma longifolia
Keywords: Ac; acetyl; βAR; beta adrenergic receptor; DEX; dexamethasone; DMEM; Dulbecco's Modified Eagle's medium; EC50; half maximal effective concentration; ERK; extracellular signal-regulated kinase; ESI; electrospray ionization; FBS; fetal bovine serum; HMBC;
Short term culture with cAMP modulators before vitrification significantly improve actin integrity in bovine oocytes
Keywords: Forskolin; IBMX; Vitrification; Pre-IVM; VG oocytes;
Technical Note: A comparison among adipogenic induction protocols for dedifferentiated fat (DFAT) cells obtained from subcutaneous fat of pigs
Keywords: Adipogenesis; Adipocyte; IBMX; Insulin;
Anti-adipogenesis mechanism of pterostilbene through the activation of heme oxygenase-1 in 3T3-L1 cells
Keywords: Pterostilbene; Adipogenesis; Adipocytes; Heme oxygenase-1; CHOP10; Ptero; Pterostilbene; MCE; Mitotic clonal expansion; CoPP; Cobalt protoporphyrin; TG; Triglyceride; DEX; Dexamethasone; IBMX; 3-isobutyl-1-methylxanthine; C/EBP; CCAAT-enhancer-binding pro
Effects of pressed degreased walnut meal extracts on lipid metabolism in postnatally monosodium glutamate-induced mice and 3T3-L1 preadipocytes
Keywords: ALT; alanine transaminase; AST; aspartate transaminase; BW; body weight; DM; diabetes mellitus; DMEM; Dulbecco's modified Eagle's medium; ESI; electrospray ionization; FBS; fetal bovine serum; GAE; gallic acid equivalents; GSH-PX; glutathione peroxida
Functional screening for G protein-coupled receptor targets of 14,15-epoxyeicosatrienoic acid
Keywords: 14,15-EET (EET); 14,15-epoxyeicosatrienoic acids; 14,15-EEZE; 14,15-epoxyeicosa-5(Z)-enoic acid; VSMCs; vascular smooth muscle cells; GPCR; G protein-coupled receptor; CFTR; Cystic Fibrosis Transmembrane Conductance Regulator; PKA; Protein Kinase A; PTG;
Toxicity of Cry1A toxins from Bacillus thuringiensis to CF1 cells does not involve activation of adenylate cyclase/PKA signaling pathway
Keywords: Bacillus thuringiensis; CF1 cell line; Cry toxins; Mechanism of action; AC/PKA pathway; MAPK p38; Bt; Bacillus thuringiensis; 3d-Cry; three domain Cry toxins; APN; aminopeptidase N; ALP; alkaline phosphatase; PKA; protein kinase A; AC; adenylate cyclase;
Novel signaling of dynorphin at κ-opioid receptor/bradykinin B2 receptor heterodimers
Keywords: AC; adenylyl cyclase; B1R; bradykinin B1 receptor; B2R; bradykinin B2 receptor; BK; bradykinin; BRET; bioluminescence resonance energy transfer; CFP; cyan fluorescent protein; CNS; central nervous system; CRE; cAMP-response element; CREB; cAMP-response el
Nitric oxide-coupled signaling in odor elicited molecular events in the olfactory center of the terrestrial snail, Helix pomatia
Keywords: 5-HT; 5-hydroxytryptamine or serotonin; ACh; acetylcholine; AGC-S-P; phosphorylated substrate of the AGC-family protein kinase; Akt; protein kinase B; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; APV; (2R)-amino-5-phosphonovaleric acid; B
PPARγ-mediated G-protein coupled receptor 120 signaling pathway promotes transcriptional activation of miR-143 in adipocytes
Keywords: PPARγ; peroxisome proliferator-activated receptor γ; miRNA; microRNA; PPREs; peroxisome proliferator response elements; GPR 120; G-protein coupled receptor 120; DMEM; Dulbecco's modified Eagle's medium; DHA; docosahexaenoic acid; IBMX; isobutylmethylxan
Pharmacological preclinical characterization of LAS190792, a novel inhaled bifunctional muscarinic receptor antagonist /β2-adrenoceptor agonist (MABA) molecule
Keywords: COPD; Bronchodilator; Long-acting β2-adrenoceptor agonist; Long-acting muscarinic antagonist; ACh; acetylcholine; ANOVA; analysis of variance; β; beta-adrenoceptor; cAMP; cyclic adenosine monophosphate; CHO; Chinese hamster ovary; CI; confidence interva
Maternal SENP7 programs meiosis architecture and embryo survival in mouse
Keywords: meiosis I/II; the first/second meiotic division; MI/MII; metaphase I/II; MPF; M-phase promoting factor; Cdk1; Cyclin-dependent kinase 1; APC; anaphase promoting complex; BrdU; bromodeoxyuridine; ATM; ataxia telangiectasia mutated; ATR; ataxia telangiectas