Keywords: Chronic kidney disease; Renal fibrosis; Natural products; Traditional Chinese medicine; TGF-β/Smad; ACE; angiotensin-converting enzyme; AGT; angiotensinogen; AR; alismatis rhizoma; AT1R; angiotensin II type 1 receptor; AAN; aristolochic acid nephropathy
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Keywords: ATM; ataxia telangiectasia mutated; ATR; ATM-Rad3-related; AMPK; AMP-activated protein kinase; AD; Alzheimer's disease; ARE; antioxidant response element; ATF6; activating transcription factor 6; BiP; binding immunoglobulin protein; BRAC1; Breast cancer 1
Keywords: AC; adenylyl cyclase; ALG-2; apoptosis-linked gene 2 product; Alix; ALG-2-interacting protein X; Bcl10; B-cell lymphoma/leukemia protein 10; CaM; calmodulin; CaM-BD; CaM-binding domain; CaM-BP; CaM-binding protein; CARD; caspase-recruitment domain; Carma1
Keywords: 5-HT; 5-hydroxytryptamine; 5-HTT; 5-hydroxytryptamine transporter; AC; adenylyl cyclase; AD; Alzheimer's disease; Akt; protein kinase B; AMPAR; α-amino-3-hydroxy-5-mthhyl-4-isoxazolepropionic acid receptor; apCAM; Aplysia cell adhesion molecules; ASD;
Keywords: HS; hemorrhagic shock; AKI; acute kidney injury; TBSA; total body surface area; GFR; glomerular filtration rate; BUN; blood urea nitrogen; RIFLE; Risk, Injury, Failure, Loss of kidney function, End-stage kidney disease; ADQI; Acute Dialysis Quality Initia
Keywords: AhR; arylhydrocarbon receptor; AGE; advanced glycation end products; ERK; extracellular signal regulated kinases; HSP; Heat Shock Protein; IRR; infrared radiation; JNK1/2; Jun N-terminal kinase; MITF; melanogenesis associated transcription factor; MMP; ma
Keywords: ACC; acetyl-CoA carboxylase; ApoB; apolipoprotein B; ApoCII; apolipoprotein C-II; APPL-1; adaptor protein containing pleckstrin homology domain, phosphotyrosine binding domain and a leucine zipper motif; CD36; fatty acid translocase; CETP; cholesteryl est
Keywords: ABCB; ATP-binding cassette sub-family B; Apo; apolipoprotein; ASBT; apical sodium dependent bile acid transporter; BDL; bile duct ligation; BSEP; bile salt export pump; CA; cholic acid; CDCA; chenodeoxycholic acid; C/EBP; CCAAT-enhancer-binding protein; C
Keywords: AC; adenylate cyclase; β-AR; β-adrenergic receptor; CaM; calmoduline; cAMP; cyclic adenosine monophosphate; CHO; Chinese hamster ovary; EGFR; epidermal growth factor receptor; ERK; extracellular signal-regulated kinase; DAG; diacylglycerol; DR; dopamine
Keywords: IPF; idiopathic pulmonary fibrosis; AT1; angiotensin type 1 receptor; TGF; Transforming growth factor; BALF; bronchoalveolar lavage fluid; PPARs; peroxisome proliferator activated receptors; ARBs; angiotensin receptor blockers; CCR2b; chemokine C-C moti
Keywords: Carotid stenosis; Cell adhesion; Cell surface markers; Gene expression; Immunophenotyping; Mononuclear cells; Thrombosis; ATF; atrial fibrillation; BP; blood pressure; BMI; body mass index; CV; cardiovascular; CEA; carotid endarterectomy; CDP; carotid dis
Keywords: ACTDs; autoimmune connective tissue diseases; SLE; systemic lupus erythematosus; RA; rheumatoid arthritis; SSc; systemic sclerosis; SS; Sjögren's syndrome; MCTD; mixed connective tissue disease; TLRs; IL-1R-like receptors; DAMPs; danger-associated molecu
The effect of cilostazol, a phosphodiesterase 3 (PDE3) inhibitor, on human hair growth with the dual promoting mechanisms
Keywords: DMEM; Dulbecco's modified Eagle medium; DPCs; dermal papilla cells; ERK; extracellular signal-regulated kinase; FBS; fetal bovine serum; H&E; hematoxylin and eosin; HFs; hair follicles; HGF; hepatocyte growth factor; IGF; insulin-like growth factor; IGF
Lrp6 is a target of the PTH-activated αNAC transcriptional coregulator
Keywords: αNAC; α chain of nascent polypeptide associated complex; PTH; Parathyroid Hormone; PKA; protein kinase A; ChIP; chromatin immunoprecipitation; ChIP-Seq; ChIP-sequencing; LRP6; Low density lipoprotein receptor-Related Protein 6; iPTH; intermittent PTH; P
New developments on skin fibrosis - Essential signals emanating from the extracellular matrix for the control of myofibroblasts
Keywords: αSMA; alpha smooth muscle actin; BMP; bone morphogenetic protein; COMP; cartilage oligomeric matrix protein; DDR; discoidin-domain receptor; ECM; extracellular matrix; FACIT; fibril-associated collagen with interrupted triple helices; HSP47; heat shock p
KRAS-Mutant non-small cell lung cancer: From biology to therapy
Keywords: BATTLE; Biomarker-Integrated Approaches of Targeted Therapy for Lung Cancer Elimination; BET; bromodomains and extra-terminal domain; CDK; cyclin-dependent kinase; Chk1; checkpoint kinase 1; CI; confidence interval; CUSTOM; Molecular Profiling and Targete
Calcimycin induced IL-12 production inhibits intracellular mycobacterial growth by enhancing autophagy
Keywords: M. bovisBCG; Mycobacterium bovis BCG; M. tb; Mycobacterium tuberculosis; TB; Tuberculosis; P2RX7; Purinergic receptor P2X7; Atg; Autophagy-related gene; LC3; Microtubule-associated protein 1A/1B-light chain 3; 3-MA; 3-methyladenine; Baf-A1; Bafilomycin A1
Differential roles of PKC isoforms (PKCs) in GnRH stimulation of MAPK phosphorylation in gonadotrope derived cells
Keywords: GnRH; PKCα; PKCβII; PKCδ; PKCε; MAPK; ERK; JNK; p38; Gonadotropes; LβT2 cells; αT3-1 cells; anti-DP antibodies; anti-diphospho-antibodies; DAG; diacylglycerol; DN; dominant negative; ERK; extracellular signal-regulated kinase; FSH; follicle stimula
The feedback loop of “EMMPRIN/NF-κB” worsens atherosclerotic plaque via suppressing autophagy in macrophage
Keywords: Atherosclerosis; Extracellular matrix metalloproteinase inducer; Macrophage autophagy; Nuclear factor kappa B; Vulnerable plaque; AMPK; Adenosine Monophosphate Activated Protein Kinase; ApoEÂ â/â; Â Apolipoprotein E-deficient; AS; atherosclerosis; CQ;
DNMT1 mediated promoter methylation of GNAO1 in hepatoma carcinoma cells
Keywords: HCC; hepatic celluler cancer; GNAO1; Guanine nucleotide-binding protein α1; BSP; bisulfite sequence PCR; DAC; 5-Aza-2â²-deoxycytidine; TSA; Trichostatin A; DNMT-1; DNA methyltransferase 1; TGF-β; transforming growth factor β; Src; steroid receptor cof
The p38 Mitogen-Activated Protein Kinase Critically Regulates Human Keratinocyte Inflammasome Activation
Keywords: ERK; extracellular signal-regulated kinase; HPK; human primary keratinocyte; JNK; Jun N-terminal kinase; MAPK; mitogen-activated protein kinase; NLR; NOD-like receptor; siRNA; small interfering RNA;
The effects of wild bitter gourd fruit extracts on ICAM-1 expression in pulmonary epithelial cells of C57BL/6J mice and microRNA-221/222 knockout mice: Involvement of the miR-221/-222/PI3K/AKT/NF-κB pathway
Keywords: WBGE; Inflammation; ICAM-1; miR-221/-222; PI3K/AKT; NF-κB; AKT; protein kinase B; C; Control; CH; charantin; COPD; chronic obstructive pulmonary disease; DMEM; Dulbecco's modified Eagle's medium; ERK; extracellular-signal-regulated kinase; ICAM; intercel
ER stress and cancer: The FOXO forkhead transcription factor link
Keywords: Endoplasmic reticulum; ER stress; Cancer; FOXO; Forkhead transcription factors; Unfolded protein response; AKT; Protein Kinase B; AKT1; Protein Kinase B Alpha; AMPK; AMP-activated protein kinase; ASK1; Apoptosis Signal Regulated Kinase 1; ATF4; Activating
Activation of renal profibrotic TGFβ controlled signaling cascades by calcineurin and mTOR inhibitors
Keywords: AP-1; activator protein 1; CNI; calcineurin inhibitor(s); ECM; extracellular matrix; EMT; epithelial to mesenchymal transition; ERK; extracellular signal regulated kinase; FKBP; FK506 binding protein; JNK; Jun N-terminal kinase; LAP; latency-associated pr
A partnership with the proteasome; the destructive nature of GSK3
Keywords: AMPK; AMP-activated protein kinase; ARE; antioxidant response element; β-TrCP; beta-transducin repeat containing protein; CKI; casein kinase-1; CHD; chromatin helicase DNA-binding factor; CRY; cryptochrome; EMT; epithelial-mesenchymal transition; FGD; fa
HDL-apoA-I induces the expression of angiopoietin like 4 (ANGPTL4) in endothelial cells via a PI3K/AKT/FOXO1 signaling pathway
Keywords: apoA-I; apolipoprotein A-I; ANGPTL4; angiopoietin like 4; CETP; cholesterol ester transfer protein; CHX; cycloheximide; CVD; cardiovascular disease; EBM; endothelial cell basal medium; eNOS; endothelial NO synthase; ERK; extracellular signal-regulated kin
Impact of obesity and overweight on DNA stability: Few facts and many hypotheses
Keywords: AGEs; advanced glycation end products; AP-1; activating protein -1; APE1; apurinic/apyrimidinic endonuclease 1; BER; base excision repair; BMI; body mass index; CAF; cafeteria diet; CAT; Catalase; CBMN-Cyt; cytokinesis block micronucleus cytome assay; CEL
NF-Y in invertebrates
Keywords: NF-Y; Nuclear Factor Y-box; C. elegans; Caenorhabditis elegans; bsk; basket; RNAi; RNA interference; MF; morphogenetic furrow; dsRNA; double stranded RNA; JNK; Jun N-terminal kinase; ChIP; chromatin immunoprecipitation; Abd-B; Abdominal-B; GMR; Glass Mult
A Sonic hedgehog coreceptor, BOC regulates neuronal differentiation and neurite outgrowth via interaction with ABL and JNK activation
Keywords: Shh; Sonic hedgehog; BOC; Brother of CDO; CDO; cell adhesion molecular downregulated by ocogenes; JNK; Jun N-terminal kinase; EC; embryonal carcinoma cell; NPC; neural progenitor cell; DCC; deleted in colorectal cancer; ROBO; roundabout; GLI; glioma-assoc
Anti-dsDNA antibodies and resident renal cells - Their putative roles in pathogenesis of renal lesions in lupus nephritis
Keywords: C1q; complement 1q; CDR; complementarity determining region; CLIFT; Crithidia luciliae indirect immunofluorescence test; CTX; cyclophosphamide; dsDNA; double-stranded deoxyribonucleic acid; ELISA; enzyme-link immunosorbent assay; ER; endoplasmic reticulum
Calcitonin gene-related peptide contributes to peripheral nerve injury-induced mechanical hypersensitivity through CCL5 and p38 pathways
Keywords: ANOVA; analysis of variance; CatS; cathepsin S; cDMEM; complete Dulbecco's Modified Eagle Media; CGRP; calcitonin gene-related peptide; COX-2; cyclooxygenase 2; ELISA; enzyme-linked immunosorbent assay; ERK; extracellular signal-regulated kinase; IACUC; I
The activation of the NF-κB-JNK pathway is independent of the PI3K-Rac1-JNK pathway involved in the bFGF-regulated human fibroblast cell migration
Keywords: bFGF; basic Fibroblast Growth Factor; NF-κB; nuclear factor kappa B; c-JNK; Jun N-terminal kinase; PI3 K; phosphatidylinositol 3-kinase; FGFR; fibroblast growth factor receptor; RNA-Seq; RNA-Sequencing; IκB-α; inhibitor of nuclear factor kappa B-alpha;
The cytoprotective effect of biglycan core protein involves Toll-like receptor 4 signaling in cardiomyocytes
Keywords: TLR4; Toll-like receptor 4; SI/R; simulated ischemia/reperfusion injury; rhBGNc; recombinant human biglycan core protein; GAG; glycosaminoglycan; TGFβ; transforming growth factor-beta; BSA; bovine serum albumin; D-PBS; Dulbecco's phosphate-buffered salin
Potent effects of dioscin against gastric cancer in vitro and in vivo
Keywords: Apoptosis; Cell migration; Dioscin; Gastric cancers; Proteomics; iTRAQ; isobaric tags for relative and absolute quantitation; MTT; 3-(4, 5-dimethylthiazol-2-yl) -2,5-diphenyl tetrazolium bromide; AO; acridine orange; EB; ethidium bromide; DAPI; 4,6-diamid
Associate Editor: P. MolenaarActivation of endogenous antioxidants as a common therapeutic strategy against cancer, neurodegeneration and cardiovascular diseases: A lesson learnt from DJ-1
Keywords: DJ-1; Endogenous antioxidant; Mechanism-oriented therapy; Disease-oriented therapy; ASK1; apoptosis signal regulating kinase; JNK; Jun N-terminal kinase; NQO1; NAD(P)H:quinone oxidoreductase 1; Nrf2; nuclear factor erythroid 2-related factor; p53; tumor p
A novel link between FMR gene and the JNK pathway provides clues to possible role in malignant pleural mesothelioma
Keywords: MPM; malignant pleural mesothelioma; MMP; matrix metalloprotease; JNK; Jun N-terminal kinase; FMR; fragile X mental retardation gene; dFMR; Drosophila fragile X mental retardation gene; UAS; upstream activation sequence; BM; basement membrane; Malignant p
A review on the possible molecular mechanism of action of N-acetylcysteine against insulin resistance and type-2 diabetes development
Keywords: N-acetyl-l-cysteine (NAC) (PubChem CID: 12035); AKT; protein kinase B; AP-1; activator protein 1; CCL2; chemokine (C-C motif) ligand 2; eNOS; endothelial nitric oxide synthase; ERK; extracellular signal-regulated kinase; FFA; free fatty acid; GLUT; gluc
Complex regulation of CREB-binding protein by homeodomain-interacting protein kinase 2
Keywords: BDNF; brain-derived neurotrophic factor; CBP; CREB-binding protein; C/EBP; CCAAT/enhancer binding protein; CRD1; cell cycle regulatory domain 1; CREB; cAMP-response element binding protein; CtBP; C-terminal-binding protein; DYRK; dual-specificity tyrosine
MAPK signaling triggers transcriptional induction of cFOS during amino acid limitation of HepG2 cells
Keywords: AA; amino acid; AAR; AA response; ActD; actinomycin D; ASNS; asparagine synthetase; ATF4; activating transcription factor 4; cFOS; FBJ murine osteosarcoma viral oncogene homolog; DOX; doxycycline; eIF2; eukaryotic initiation factor 2; ERK; extracellular-s
Changes in immune cell signalling, apoptosis and stress response functions in mice returned from the BION-M1 mission in space
Keywords: NF-kappaB; nuclear factor kappa B; IKK; I-kappaB kinase; SAPK/JNK; stress activated protein kinase; JNK; Jun N-terminal kinase; IFN; interferon; Hsp; heat shock protein; IL; interleukin; TNF; tumour necrosis factor; IRF-3; interferon regulatory factor; GA
The immune signaling pathways of Manduca sexta
Keywords: Insect immunity; RNA-Seq; Transcriptome; Gene annotation; Expression profiling; Atg; autophagy-related protein; aPKC; atypical protein kinase C; CF; control fat body; CH; control hemocytes; IF; induced fat body; IH; induced hemocytes; Deaf; deformed epide
Methylseleninic acid promotes antitumour effects via nuclear FOXO3a translocation through Akt inhibition
Keywords: Methylseleninic acid (PubChem CID: 161597); Sodium selenite (PubChem CID: 24934); Cisplatin (PubChem CID: 441203); LY294002 (PubChem CID: 3973); MSA; methylseleninic acid; Se; selenium; PPP; pentose phosphate pathway; TCA; tricarboxylic acid; ROS; reactiv
Current knowledge and pharmacological profile of berberine: An update
Keywords: 5-HT; 5-hydroxytryptamine; 6-OHDA; 6-hydroxydopamine; AChE; acetylcholinesterase; AD; Alzheimer's disease; AMPK; AMP-activated protein kinase; BBB; blood brain barrier; BChE; butyrylcholinestesrase; CD; cluster of differentiation; Cdk; cyclin-dependent ki
Astrogliosis as a therapeutic target for neurodegenerative diseases
Keywords: AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; ATP; adenosine triphosphate; BB14®; nerve growth factor-like peptide; BDNF; brain-derived neurotrophic factor; Ca2+; calcium; CNS; central nervous system; COX-1/2; cyclooxygenase-1/2; EAAC1; ex
Research ArticlePTPRO plays a dual role in hepatic ischemia reperfusion injury through feedback activation of NF-κB
Keywords: IR; ischemia reperfusion; ROS; reactive oxygen species; KCs; kupffer cells; TNFα; tumor necrosis factor α; IL-1β; interleukin-1β; NF-κB; Nuclear factor-κB; JNK; Jun N-terminal kinase; IκB; inhibitor of NF-κB; IKK; IκB kinase; PTPRO; Protein tyros
Wnt5a: A player in the pathogenesis of atherosclerosis and other inflammatory disorders
Keywords: Wnt5a; Macrophages; Inflammation; Atherosclerosis; Inflammatory disorders; Fz; frizzled; LRP; lipoprotein receptor-related protein; Ror2; receptor tyrosine kinase-like orphan receptor; DSH; disheveled; CaMKII; calmodulin dependent protein kinase II; PKC;
Tetrahydrocurcumin induces G2/M cell cycle arrest and apoptosis involving p38 MAPK activation in human breast cancer cells
Keywords: AO; acridine orange; cdc 2; cell division cycle 2; CDK; cyclin-dependent kinase; CDKI; cyclin-dependent kinase inhibitor; DMSO; dimethyl sulfoxide; ERK; extracellular signal-regulated kinase; FBS; fetal bovine serum; JNK; Jun N-terminal kinase; MAPK; mito
PARP-1 activation causes neuronal death in the hippocampal CA1 region by increasing the expression of Ca2Â +-permeable AMPA receptors
Keywords: AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; AP5; 2-amino-5-phosphonopentanoate; AMPK; 5ⲠAMP-activated protein kinase; AIF; apoptosis-inducing factor; Cyt-C; cytochrome-C; JNK; Jun N-terminal kinase; GluA1; glutamate AMPA receptor subun
Identification of conserved and novel microRNAs in Manduca sexta and their possible roles in the expression regulation of immunity-related genes
Keywords: Posttranscriptional regulation; Illumina sequencing; Lepidoptera; Insect immunity; Target site prediction; Alk; anaplastic lymphoma kinase; AMP; antimicrobial peptides; ANKRD54; ankyrin repeat domain 54; Aop; anterior open; aPKC; atypical protein kinase C
Mechanisms of allergy and clinical immunologyT cell-derived microvesicles induce mast cell production of IL-24: Relevance to inflammatory skin diseases
Keywords: IL-24; mast cells; microvesicles; T cells; CCL3; Chemokine (C-C motif) ligand 3; CCL7; Chemokine (C-C motif) ligand 7; ERK; Extracellular signal-regulated kinase; JNK; Jun N-terminal kinase; MAPK; Mitogen-activated protein kinase; MC; Mast cell; mvT; Micr