Keywords: هدف پستانداران مجتمع رپامایسین 1; ADA; anti-drug antibodies; AMPK; 5â² adenosine monophosphate-activated protein kinase; aHUS; atypical hemolytic uremic syndrome; AMD; age-related macular degeneration; APC; antigen presenting cells; AT; anaphylatoxin; BTK; Bruton's tyrosine kinase; C1q
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Keywords: هدف پستانداران مجتمع رپامایسین 1; Diabetic cardiomyopathy; Curcumin; Autophagy; Apoptosis; Beclin1; 3-MA; 3-methyladenine; 4E-BP1; 4E-binding protein 1; AMPK; 5â² adenosine monophosphate -activated protein kinase; BH; Bcl-2-homology; CC; AMPK inhibitor compound C; mTOR; mammalian target
Keywords: هدف پستانداران مجتمع رپامایسین 1; ATM; ataxia telangiectasia mutated; ATR; ATM-Rad3-related; AMPK; AMP-activated protein kinase; AD; Alzheimer's disease; ARE; antioxidant response element; ATF6; activating transcription factor 6; BiP; binding immunoglobulin protein; BRAC1; Breast cancer 1
Keywords: هدف پستانداران مجتمع رپامایسین 1; ACh; Acetylcholine; A-P; Anterior-posterior; AChE; Acetylcholinesterase; AD; Alzheimer's disease; Akt; Serine/threonine kinase; ALA; Aplpha linoleic acid; AM; Amygdala; AMPA; α-Amino- 3-hydroxy-5-methyl-4-isoxazolepropionic acid; AP-7; 2-amino-7-phosph
Keywords: هدف پستانداران مجتمع رپامایسین 1; Atherosclerosis; Cardiovascular diseases; Cell cycle; Proliferation; Pulmonary hypertension; Restenosis; Signaling pathway; Vascular smooth muscle cells; ACE; angiotensin converting enzyme; aFGF; acidic FGF; Ang II; angiotensin II; AP-1; activating protei
Keywords: هدف پستانداران مجتمع رپامایسین 1; ACL; ATP citrate lyase; AMPK; adenosine monophosphate kinase; ARG1; l-arginine-metabolizing enzyme arginase 1; BCAA; branched-chain amino acid; Bcl2; B-cell lymphoma 2; CAF; cancer-associated fibroblast; CIC; cancer-initiating cell; COX2; cytochrome oxida
Keywords: هدف پستانداران مجتمع رپامایسین 1; aKG; alfa keto glutarate; Akt/PKB; serine/threonine-specific protein kinase B; AMPK; 5â² adenosine monophosphate-activated protein kinase; ASPEN; American Society of Parenteral and Enteral Nutrition; ATP; adenosine triphosphate; BIA; bio-electric impedan
Keywords: هدف پستانداران مجتمع رپامایسین 1; BD; Bipolar Disorder; STEP-BD; Systematic Treatment Enhancement Program for Bipolar disorder; DFNB31; Deafness, Autosomal Recessive 31; SORCS2; Sortilin-Related VPS10 Domain Containing Receptor 2; NRXN1; Neurexin 1; CNTNAP2; Contactin Associated Protein-L
Keywords: هدف پستانداران مجتمع رپامایسین 1; mTORC1; mammalian target of rapamycin complex 1; SADF; senescence-associated DNA damage foci; SAHF; senescence-associated heterochromatic foci; SASP; senescence-associated secretory phenotype; SA-β-GAL; senescence-associated β-galactosidase; Cellular se
Keywords: هدف پستانداران مجتمع رپامایسین 1; Naringin; Kainic acid; Dentate gyrus; Granule cell dispersion; Mammalian target of rapamycin complex 1;
Keywords: هدف پستانداران مجتمع رپامایسین 1; Feedback regulation; Systems stability; Mathematical modelling; Network analysis; Drug resistance, Signal transduction, Network dynamics; MST2; Mammalian STE20-like protein kinase 2; Raf-1; v-raf-1 murine leukemia viral oncogene homolog 1; MEK; Mitogen-Ac
Keywords: هدف پستانداران مجتمع رپامایسین 1; αKG; alpha ketoglutarate; BCAA/LEU; branched chain amino acids enriched with l-leucine; CHOP; C/EBP homology protein; eIF2α; eukaryotic initiation factor 2 alpha; GADD34; growth arrest and DNA damage inducible protein 34; GCN2; general control non-depre
Keywords: هدف پستانداران مجتمع رپامایسین 1; GLS; glutaminase; GDH; glutamate dehydrogenase; ALT; alanine aminotransferase; AST; aspartate aminotransferase; TCA; tricarboxylic acid cycle; SS; succinylCoA synthetase; ME; malic enzyme; IDH1; isocytrate dehydrogenase; AARE; aminoacid responsive element
Keywords: هدف پستانداران مجتمع رپامایسین 1; ACAT; acyl-CoA cholesterol acyltransferase; ACC; acetyl CoA carboxylases; ACLY; ATP citrate lyases; ACSL; acyl CoA synthetases long chain family; ADRP; adipose differentiation related protein; AGP; advanced glycation end products; AGPAT; acylglycerophosph
Keywords: هدف پستانداران مجتمع رپامایسین 1; BRAF; B-Raf protein; BRD4; bromodomain-containing protein 4; CDK6; cyclin-dependent kinase 6; ERBB1; epidermal growth factor receptor; ERG; ETS-family oncogenic transcription factor; ERK; extracellular signal regulated protein kinase; FOS; FBJ murine oste
Keywords: هدف پستانداران مجتمع رپامایسین 1; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; ANOVA; Analysis of variance; Aβ; amyloid β; bHLH; basic Helix-Loop-Helix; C4; complement C4; CLEAR; coordinated lysosomal expression and regulation; Cyba; cytochrome b-245 light chain; DW; d
Different concentrations of docosahexanoic acid supplement during lactation result in different outcomes in preterm Sprague-Dawley rats
Keywords: هدف پستانداران مجتمع رپامایسین 1; DHA; Docosahexanoic acid; LCPUFA; long chain polyunsaturated fatty acid; PKB; protein kinase B; mTORC1; mammalian target of rapamycin complex 1; Sug; sufficient DHA Group; Eng; enriched DHA Group; Exg; excess DHA Group; DeG; deficient DHA Group; PND; post
Melanoma metabolism contributes to the cellular responses to MAPK/ERK pathway inhibitors
Keywords: هدف پستانداران مجتمع رپامایسین 1; MAPK; mitogen-activated protein kinase; BRAF; v-raf murine sarcoma viral oncogene homolog B1; MEK; mitogen-activated protein/extracellular signal- regulated kinase kinase; ERK; extracellular signal-regulated kinase; HIF-1α; hypoxia inducible factor 1 alp
MTOR pathway in focal cortical dysplasia type 2: What do we know?
Keywords: هدف پستانداران مجتمع رپامایسین 1; FCD; focal cortical dysplasia; FCD II; focal cortical dysplasia type 2; FLE; frontal lobe epilepsy; GG; ganglioglioma; HME; hemimegalencephaly; ILAE; International League Against Epilepsy; MCD; malformation of cortical development; MPPH; megalencephaly-
Enhanced Repair of UV-Induced DNA Damage by 1,25-Dihydroxyvitamin D3 in Skin Is Linked to Pathways that Control Cellular Energy
Keywords: هدف پستانداران مجتمع رپامایسین 1; 1,25(OH)2D3; 1α,25-dihydroxyvitamin D3; 2-dG; 2-deoxy-d-glucose; 8-oxo-dG; 8-oxo-2â²-deoxyguanosine; Akt; acutely transforming retrovirus AKT8 in rodent T-cell lymphoma; CPD; cyclobutane pyrimidine dimer; ÎÏm; mitochondrial membrane potential; ECAR; e
PKM2, a potential target for regulating cancer
Keywords: هدف پستانداران مجتمع رپامایسین 1; PK; pyruvate kinase; HCC; hepatocellular carcinoma; FBP; fructose 1,6-bisphosphate; SAICAR; Succinyl-5-aminoimidazole-4-carboxamide-1-ribose-50-phosphate; hnRNPs; heterogeneous nuclear ribonucleoproteins; PTB; polypyrimidine tract-binding protein; NEK2; n
Cardiac natriuretic peptides promote adipose 'browning' through mTOR complex-1
Keywords: هدف پستانداران مجتمع رپامایسین 1; Thermogenesis; UCP1; Kinases; βAR; β-adrenergic receptor; 8-Br-cAMP; 8-Bromoadenosine 3â²,5â²-cyclic monophosphate; 8-Br-cGMP; 8-Bromoguanosine 3â²,5â²-cyclic monophosphate; Akt; protein kinase B; ANP; Atrial natriuretic peptide; BNP; B-type natriur
Hydroxychloroquine efficiently suppresses inflammatory responses of human class-switched memory B cells via Toll-like receptor 9 inhibition
Keywords: هدف پستانداران مجتمع رپامایسین 1; Hydroxychloroquine; Toll-like receptor 9; Human B cell; Plasmablast; CFSE; carboxyfluorescein succinimidyl ester; CD; Cluster of differentiation; CpG; cytosine-phosphate-guanine; dsDNA; double-stranded DNA; IFN; interferon; Ig; immunoglobulin; LPS; lipopo
ZBTB38, a novel regulator of autophagy initiation targeted by RB1CC1/FIP200 in spinal cord injury
Keywords: هدف پستانداران مجتمع رپامایسین 1; ATG2; autophagy-related protein 2; ATG13; autophagy-related protein 13; ATG14; autophagy-related protein 14; ATG101; autophagy-related protein 101; ATM; ataxia telangiectasia-mutated gene; BECN1; the homologue of yeast autophagy-related protein 6; CCK-8;
ROS signalling in the biology of cancer
Keywords: هدف پستانداران مجتمع رپامایسین 1; AEJ; alternative end joining; ALL; acute lymphoblastic leukaemia; AML; acute myeloid leukaemia; Apaf-1; apoptotic protein activating factor 1; APL; acute promyelocytic leukaemia; ASK1; apoptosis signal regulating kinase 1; Bcr-Abl; breakpoint cluster-Abel
Disruption of peroxisome function leads to metabolic stress, mTOR inhibition, and lethality in liver cancer cells
Keywords: هدف پستانداران مجتمع رپامایسین 1; Peroxisome; Peroxisomal biogenesis factor 2; Mammalian target of rapamycin complex 1; Metabolic stress; Human hepatocellular carcinoma; PEXs; peroxins; PTS; peroxisome targeting signal; PBD; peroxisome biogenesis disorder; ZS; Zellweger syndrome; HCC; hum
Agmatine potentiates neuroprotective effects of subthreshold concentrations of ketamine via mTOR/S6 kinase signaling pathway
Keywords: هدف پستانداران مجتمع رپامایسین 1; Agmatine; Akt; HT22; Ketamine; Neuroprotection; p70S6 kinase; PSD95; 4E-BPs; 4E binding proteins; ANOVA; analysis of variance; DMEM; Dulbecco's Modified Eagle Medium; ECT; electroconvulsive therapy; CUS; chronic unpredictable stress; FST; forced swim test
Activation of anti-oxidant Nrf2 signaling by enone analogues of curcumin
Keywords: هدف پستانداران مجتمع رپامایسین 1; Nrf2 activation; Pyridone; Enone; Aldol condensation; Nrf2; nuclear factor erythroid 2 related factor 2; CNS; central nervous system; Keap1; Kelch-like ECH associated protein 1; NF-κB; nuclear factor kappa-light-chain enhancer of activated B cells; Maf;
Smooth muscle cell-driven vascular diseases and molecular mechanisms of VSMC plasticity
Keywords: هدف پستانداران مجتمع رپامایسین 1; Vascular smooth muscle; Vasoproliferative disease; Vascular smooth muscle cell; Phenotype switching; Signalling pathways; AJ; adherens junction; ApoE; apolipoprotein E; BMP; bone morphogenetic protein; CAD; coronary artery diseases; CADASIL; cerebral auto
Original ArticleRepletion of branched chain amino acids reverses mTORC1 signaling but not improved metabolism during dietary protein dilution
Keywords: هدف پستانداران مجتمع رپامایسین 1; BCAA; Dietary protein; FGF21; mTORC1; Diabetes; PD; protein dilution; AA; amino acid; BCAA; branched chain amino acid; AAD; amino acid diluted; mTORC1; mammalian target of rapamycin complex 1; ISR; integrated stress response; HF; high fat; NZB; New Zealan
Phosphorylation of Tudor-SN, a novel substrate of JNK, is involved in the efficient recruitment of Tudor-SN into stress granules
Keywords: هدف پستانداران مجتمع رپامایسین 1; SG; stress granule; Tudor-SN; Tudor staphylococcal nuclease; JNK; c-Jun N-terminal kinase; PKR; protein kinase R; PERK; PKR-like endoplasmic reticulum kinase; GCN2; general control nonderepressible 2; HRI; heme-regulated inhibitor kinase; eIF2α; eukaryot
DNA damage response and autophagy in the degeneration of retinal pigment epithelial cells-Implications for age-related macular degeneration (AMD)
Keywords: هدف پستانداران مجتمع رپامایسین 1; 9-1-1 complex; complex of Rad9 Rad1 and Hus1 proteins; A2E; N-retinylidene-N-retinylethanol-amine; AtRal; all-trans retinal; AMD; age-related macular degeneration; AMPK; AMP-activated protein kinase; Atg; autophagy-related gene; ATM; ataxia-telangiectasia
ReviewThe Journey of the Autophagosome through Mammalian Cell Organelles and Membranes
Keywords: هدف پستانداران مجتمع رپامایسین 1; ER; endoplasmic reticulum; ATG; autophagy-related gene; mTORC1; mammalian target of rapamycin complex 1; PI3KC3; class III PI3 kinase; PI3P; phosphatidyl-inositol-3-phosphate; COPs; coating proteins; SNAREs; small Rab GTPases, membrane fusion proteins; MA
The activation of autophagy protects neurons and astrocytes against bilirubin-induced cytotoxicity
Keywords: هدف پستانداران مجتمع رپامایسین 1; UCB; unconjugated bilirubin; TFP; trifluoroperazine; Bf; free bilirubin; 4-PBA; 4-phenyl-butyric acid; 4EBP; eukaryotic initiation factor 4E-binding protein; mTORC1; mammalian target of rapamycin complex 1; SQSTM1/p62; sequestosome-1 or ubiquitin-binding
A 15-gene signature for prediction of colon cancer recurrence and prognosis based on SVM
Keywords: هدف پستانداران مجتمع رپامایسین 1; TCGA; The Cancer Genome Atlas; LIMMA; Linear Models for Microarray data; DEGs; differentially expressed genes; SVM; support vector machine; d-CEA; draining venous blood; GEO; Gene Expression Omnibus; RMA; Robust Multichip Average; RFE; recursive feature e
A new role of GCN2 in the nucleolus
Keywords: هدف پستانداران مجتمع رپامایسین 1; GCN2; Amino acid starvation; Nucleolus; p53; RNA polymerase III; ARPP P0; acidic ribosomal phosphoprotein P0; ATF4; activating transcription factor 4; BRF1; B-related factor 1; eIF2α; eukaryotic initiation factor 2 alpha subunit; FC; fibrillar center; GA
Nudix-type motif 2 contributes to cancer proliferation through the regulation of Rag GTPase-mediated mammalian target of rapamycin complex 1 localization
Keywords: هدف پستانداران مجتمع رپامایسین 1; mTORC1; mammalian target of rapamycin complex 1; NUDT2; Nudix-type motif 2; GEFs; guanine nucleotide exchange factors; GAPs; GTPase-activating proteins; Ap4A; 5â², 5â³-p1,p4-tetraphosphate; DCIS; ductal cell in situ; IDC; invasive ductal carcinoma cell;
IRE1α links Nck1 deficiency to attenuated PTP1B expression in HepG2 cells
Keywords: هدف پستانداران مجتمع رپامایسین 1; ATF6; activating transcription factor 6; EGFR; epidermal growth factor receptor; ER; endoplasmic reticulum; HNF4α; hepatocyte nuclear factor 4α; GAP; GTPase-activating protein; HFD; high fat diet; IL-4; interleukin-4; IRE1α; inositol-requiring enzyme 1
The cochaperone BAG3 coordinates protein synthesis and autophagy under mechanical strain through spatial regulation of mTORC1
Keywords: هدف پستانداران مجتمع رپامایسین 1; BAG3; BCL2-associated athanogene; mTOR; mammalian target of rapamycin; mTORC1; mammalian target of rapamycin complex 1; TSC; tuberous sclerosis; CASA; chaperone-assisted selective autophagy; CMA; chaperone-mediated autophagy; RE; maximal eccentric resista
Protein and exercise in the prevention of sarcopenia and aging
Keywords: هدف پستانداران مجتمع رپامایسین 1; Sarcopenia; Protein; Aerobic exercise; Resistance exercise; Aging; Supplement; 1-RM; 1 repetition maximum; 4E-BP1; eukaryotic initiation factor 4E-binding protein-1; aLM; appendicular lean mass; BIA; bioelectrical impedance analysis; CSA; cross-sectiona
ALS-FTLD associated mutations of SQSTM1 impact on Keap1-Nrf2 signalling
Keywords: هدف پستانداران مجتمع رپامایسین 1; ALS; Amyotrophic lateral sclerosis; ARE; Antioxidant response element; FTLD; Frontotemporal lobar degeneration; IKKβ; Inhibitor of nuclear factor kappa-B kinase subunit beta; Keap1; Kelch-like ECH-associated protein 1; KIR; Keap1-interacting region; LIR;
Panaxatriol derived from ginseng augments resistance exercised-induced protein synthesis via mTORC1 signaling in rat skeletal muscle
Keywords: هدف پستانداران مجتمع رپامایسین 1; Ginseng; Intracellular signaling; Skeletal muscle; Rat; Resistance exercise; ERK1/2; extracellular signal-regulated kinase 1/2; IGF-1; insulin-like growth factor-1; mTORC1; mammalian target of rapamycin complex 1; TSC; tuberous sclerosis complex; PT; pa
Recent progress in the identification of adenosine monophosphate-activated protein kinase (AMPK) activators
Keywords: هدف پستانداران مجتمع رپامایسین 1; ACC; acetyl-CoA carboxylase; ADaM; allosteric drug and metabolite; AID; auto-inhibitory domain; α-RIM; α-regulatory interacting motif; AMPK; adenosine monophosphate-activated protein kinase; ASMS; affinity selection mass spectrometry; CamKKβ; Ca2+/calm
Aryl hydrocarbon receptor-dependent up-regulation of the heterodimeric amino acid transporter LAT1 (SLC7A5)/CD98hc (SLC3A2) by diesel exhaust particle extract in human bronchial epithelial cells
Keywords: هدف پستانداران مجتمع رپامایسین 1; AhR; aryl hydrocarbon receptor; BCH; 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid; CYP; cytochrome P-450; DEP; diesel exhaust particle; DEPe; diesel exhaust particle extract; DMSO; dimethyl sulfoxide; EGR1; early growth response 1; ERK; extracellular
Paeonia japonica root extract protects hepatocytes against oxidative stress through inhibition of AMPK-mediated GSK3β
Keywords: هدف پستانداران مجتمع رپامایسین 1; AA; arachidonic acid; ACC; acetyl-CoA carboxylase; ALT; alanine aminotransferase; AMPK; AMP-activated protein kinase; AST; aspartate aminotransferase; DCFH-DA; 2â²,7â²-dichlorofluorescein diacetate; 4EBP-1; eIF-4E binding protein 1; FACS; fluorescence-a
MicroRNA148b-3p inhibits mTORC1-dependent apoptosis in diabetes by repressing TNFR2 in proximal tubular cells
Keywords: هدف پستانداران مجتمع رپامایسین 1; apoptosis; diabetic nephropathy; free fatty acids; high glucose; mammalian target of rapamycin complex 1; microRNA; proximal tubular cell; hypoxia; TNF-α; TNF-α receptor;
Telomerase reverse transcriptase induces basal and amino acid starvation-induced autophagy through mTORC1
Keywords: هدف پستانداران مجتمع رپامایسین 1; Autophagy; Cell viability; Human telomerase reverse transcriptase (hTERT); Mammalian target of rapamycin complex 1 (mTORC1); Telomerase; AMPK; AMP-activated protein kinase; DMEM; Dulbecco's Modified Eagle's medium; EBSS; Earle's balanced salt solution; ER
Amino acid-dependent NPRL2 interaction with Raptor determines mTOR Complex 1 activation
Keywords: هدف پستانداران مجتمع رپامایسین 1; NPRL2; nitrogen permease regulator-like 2; mTORC1; mammalian target of rapamycin complex 1; DEPDC5; DEP domain containing 5; GATOR1; GAP activity toward Rag 1; LAMP2; lysosome-associated membrane protein 2; NPRL2; mTOR complex 1 (mTORC1); Rag GTPases; Rap
Everolimus (RAD001) ameliorates vascular cognitive impairment by regulating microglial function via the mTORC1 signaling pathway
Keywords: هدف پستانداران مجتمع رپامایسین 1; VaD; vascular dementia; mTORC1; mammalian target of rapamycin complex 1; AD; Alzheimer's disease; ROS; reactive oxygen species; GWAS; genome-wide association study; IFN; interferon; TNF-α; tumor necrosis factor alpha; IL; interleukin; Arg-1; arginase-1;
Autophagy: A double-edged sword in intervertebral disk degeneration
Keywords: هدف پستانداران مجتمع رپامایسین 1; IVD; intervertebral disk; NP; nucleus pulposus; AF; annulus fibrosus; CEPs; cartilaginous endplates; ECM; extracellular matrix; Col II; type II collagen; Col I; type I collagen; IDD; intervertebral disk degeneration; LBP; low back pain; miRNAs; microRNAs;