Keywords: Aspirin-exacerbated respiratory disease (AERD); Asthma; Aspirin (acetylsalicylic acid, ASA); Chronic rhinosinusitis with nasal polyps; Nonsteroidal antiinflammatory drugs (NSAID); Hypersensitivity; Intolerance; AERD; aspirin-exacerbated respiratory diseas
مقالات ISI (ترجمه نشده)
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Keywords: AML; acute myeloid leukemia; MUFA; monounsaturated fatty acid; CML; chronic myelogenous leukemia; ALL; acute lymphoblastic leukemia; FAO; fatty acid oxidation; CPT1a; carnitine palmitate transferase 1a; SCD1; stearoyl CoA desaturase 1; FAB; French-America
Keywords: COX-2; cycloxygenase-2; LPS; lipopolysaccharide; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; mPGES-1; microsomal prostaglandin E2 synthase-1; NO; nitric oxide; NOS-2; nitric oxide synthase; PGE2; prostaglandin E2; Naphthoimidazoles
Keywords: Trichothecenes; Cytokines; Prostaglandins; mPGES-1; Neuroinflammation
Keywords: Tendon; Injury; Tendinopathy; Pathogenesis; Inflammation; Resolution; COX; cyclooxygenase; ECM; extracellular matrix; FPR2/ALX; lipoxin A4 receptor; IFN-γ; interferon gamma; IL-1β; interleukin-1beta; LXA4; lipoxin A4; MÏ; macrophage; mPGES-1; microsoma
Keywords: Nonsteroidal anti-inflammatory drugs; Biological membranes; Membrane model systems; Pharmacokinetic properties; Therapeutic and toxic actions; ATP; adenosine triphosphate; COX; cyclooxygenase; Coxibs; COX-2 selective inhibitors; CV; cardiovascular; DPPC;
Keywords: Drug repositioning/repurposing; Computational drug repositioning; Drug rescue; Reverse virtual screening; Chemical space; mPGES-1
MM-PBSA and per-residue decomposition energy studies on 7-Phenyl-imidazoquinolin-4(5H)-one derivatives: Identification of crucial site points at microsomal prostaglandin E synthase-1 (mPGES-1) active site
Keywords: mPGES-1; Molecular dynamics simulations; MM-PBSA; Per-residue decomposition energy; Virtual screening;
Inhibition of Microsomal Prostaglandin E Synthase-1 in Cancer-Associated Fibroblasts Suppresses Neuroblastoma Tumor Growth
Keywords: Tumor microenvironment; Cancer-associated fibroblasts; mPGES-1; PGE2;
Lipopolysaccharide (LPS)-mediated priming of toll-like receptor 4 enhances oxidant-induced prostaglandin E2 biosynthesis in primary murine macrophages
Keywords: ONS; oxidative/nitrosative stress; TLR; toll-like receptor; LPS-EK (Ultrapure); lipopolysaccharide from E. coli K12; TLR4-WT macrophages; macrophages derived from wild-type mice; TLR4-KO macrophages; macrophages derived from complete TLR4 knock-out mice;
Physiological and pathophysiological implications of PGE2 and the PGE2 synthases in the kidney
Keywords: AA; arachidonic acid; CCD; cortex collecting duct; CD; collecting duct; COX; cyclooxygenase; DCT; distal convoluted tubule; DTL; descending thin limb; EP; E-prostanoid receptor (PGE2 receptor); IMCD; inner medullary collecting duct; KO; knockout; MCD; med
Inhibition of microsomal prostaglandin E synthase-1 facilitates liver repair after hepatic injury in mice
Keywords: Liver; Macrophage; Repair; Prostaglandin E2; mPGES-1; EP4;
Plant-derived mPGES-1 inhibitors or suppressors: A new emerging trend in the search for small molecules to combat inflammation
Keywords: Anti-inflammatory; Anti-rheumatism; mPGES-1; Enzyme inhibitors; Plant-derived compounds;
Secretome from hypoxia-conditioned adipose-derived mesenchymal stem cells promotes the healing of gastric mucosal injury in a rodent model
Keywords: ADMSCs; adipose-derived mesenchymal stem cells; COX2; cyclooxygenase 2; PGE2; prostaglandin E2; ErK1/2; extracellular signal-regulated kinase 1/2; MAPK; mitogen-activated protein kinase; GI; gastrointestinal; HPO CM; hypoxic-conditioned medium; Nor CM; no
AH6809 decreases production of inflammatory mediators by PGE2 - EP2 - cAMP signaling pathway in an experimentally induced pure cerebral concussion in rats
Keywords: Pure cerebral concussion; EP2 receptor; AH6809; Hippocampal CA1 neurons; Inflammatory mediators; PGE2 - EP2 - cAMP signaling pathway; TBI; traumatic brain injury; mTBI; mild traumatic brain injury; SBI; secondary brain injury; PCC; pure cerebral concu
Suppressing mPGES-1 expression by sinomenine ameliorates inflammation and arthritis
Keywords: Sinomenine (PubChem CID: 5459308); Sinomenine; mPGES-1; NF-κB; Inflammation; Rheumatoid arthritis;
Linking of mPGES-1 and iNOS activates stem-like phenotype in EGFR-driven epithelial tumor cells
Keywords: mPGES-1; iNOS; Epithelial tumor cells; Stemness; EGF; Tumorspheres; mPGES-1; microsomal prostaglandin E synthase-1; PGE-2; prostaglandin E-2; EGF; epidermal growth factor; EMT; epithelial to mesenchymal transition; ALDH; aldehyde dehydrogenase; PKA; prote
Discovery and characterization of [(cyclopentyl)ethyl]benzoic acid inhibitors of microsomal prostaglandin E synthase-1
Keywords: mPGES-1; Prostaglandin pathway; Bioavailability; Biomarker;
Hit-to-lead optimization of phenylsulfonyl hydrazides for a potent suppressor of PGE2 production: Synthesis, biological activity, and molecular docking study
Keywords: Inflammation; Prostaglandin E2; Phenylsulfonyl hydrazide; mPGES-1; Molecular docking study
Opposing roles of TGF-β in prostaglandin production by human follicular dendritic cell-like cells
Keywords: COX; cyclooxygenase; FDC; follicular dendritic cell; GC; germinal center; IL-1Ra; IL-1 receptor antagonist; MAPK; mitogen-activated protein kinase; mPGES-1; microsomal prostaglandin I synthase-1; PG; prostaglandin; Follicular dendritic cell; TGF-β; Prost
Insights into the structure activity relationship of mPGES-1 inhibitors: Hints for better inhibitor design
Keywords: mPGES-1; Inflammation; Arthritis; Osteoarthritis; Molecular docking; Structure-activity relationship
Inhibition of GSK-3 reduces prostaglandin E2 production by decreasing the expression levels of COX-2 and mPGES-1 in monocyte/macrophage lineage cells
Keywords: GSK-3; PGE2; COX-2; mPGES-1; Anti-inflammatory drug;
Effects of prostaglandin E2 on cells cultured from the rat organum vasculosum laminae terminalis and median preoptic nucleus
Keywords: [Ca2+]i; intracellular calcium concentration; ANOVA; analysis of variance; COX-2; cyclooxygenase-2; EDTA; ethylenediaminetetraacetic acid; GABA; gamma amino butyric acid; HBSS; Hanks Balanced Salt Solution; HEPES; 4-(2-hydroxyethyl)-1-piperazineethanesulf
Characterization of 3,3-dimethyl substituted N-aryl piperidines as potent microsomal prostaglandin E synthase-1 inhibitors
Keywords: mPGES-1; Prostaglandin pathway; Dog bioavailability; Biomarker;
Revealing the effect of 6-gingerol, 6-shogaol and curcumin on mPGES-1, GSK-3β and β-catenin pathway in A549 cell line
Keywords: A549; 6-Gingerol; 6-Shogaol; mPGES-1; GSK-3β; β-Catenin;
Stauntoside B inhibits macrophage activation by inhibiting NF-κB and ERK MAPK signalling
Keywords: NO; nitric oxide; PGE2; prostaglandin E2; NSAIDs; non-steroidal anti-inflammatory drugs; qRT-PCR; quantitative real-time polymerase chain reaction; LPS; lipopolysaccharide; IFN-γ; interferon γ; G-CSF; granulocyte colony stimulating factor; TNF-α; tumor
BRP-187: A potent inhibitor of leukotriene biosynthesis that acts through impeding the dynamic 5-lipoxygenase/5-lipoxygenase-activating protein (FLAP) complex assembly
Keywords: 5-LO; 5-lipoxygenase; AA; arachidonic acid; COX; cyclooxygenase; cPLA2; cytosolic phospholipase A2; FLAP; 5-lipoxygenase-activating protein; fMLP; N-formyl-methionyl-leucyl-phenylalanine; H(P)ETE; hydro(pero)oxyeicosatetraenoic acid; HHT; hydroxyheptadeca
Roles of mPGES-1, an inducible prostaglandin E synthase, in enhancement of LPS-induced lymphangiogenesis in a mouse peritonitis model
Keywords: Lymphangiogenesis; Inflammation; Prostaglandin; Synthase; Cyclooxygenase-2; mPGES-1; Peritonitis
Discovery of novel, non-acidic mPGES-1 inhibitors by virtual screening with a multistep protocol
Keywords: Inflammation; mPGES-1; Virtual screening; 3D pharmacophore; Kruskal-Wallis test;
Instability of a dinucleotide repeat in the 3â²-untranslated region (UTR) of the microsomal prostaglandin E synthase-1 (mPGES-1) gene in microsatellite instability-high (MSI-H) colorectal carcinoma
Keywords: mPGES-1; Dinucleotide repeat; Microsatellite instability; Colorectal cancer;
Protective effect of (±)α-tocopherol on brominated diphenyl ether-47-stimulated prostaglandin pathways in human extravillous trophoblasts in vitro
Keywords: BDE-47; brominated diphenyl ether-47; carboxy-H2DCF-DA; 6-carboxy dichlorodihydrofluorescein diacetate; COX-2; cyclooxygenase-2; cPGES; cytosolic prostaglandin E synthase; DCF; dichlorofluorescein; cDCF; carboxydichlorofluorescein; DMSO; dimethyl sulfoxid
Close teamwork between Nrf2 and peroxiredoxins 1 and 6 for the regulation of prostaglandin D2 and E2 production in macrophages in acute inflammation
Keywords: AA; arachidonic acid; AP-1; activator protein-1; ARE; antioxidant-response element; BMDM; bone marrow-derived macrophage; COX-2; cyclooxygenase-2; DEX; dexamethasone; 15d-PGJ2; 15-deoxy-Î12,14-prostaglandin J2; ERK2; extracellular-regulated kinase 2; GST
Roles of microsomal prostaglandin E synthase-1 in lung metastasis formation in prostate cancer RM9 cells
Keywords: Metastasis; COX-2; mPGES-1; Matrix metalloproteinases; Prostate cancer
IL-27 affects helper T cell responses via regulation of PGE2 production by macrophages
Keywords: DC; dendritic cell; PG; prostaglandin; COX; cyclooxygenase; BMDM; bone marrow-derived macrophage; BM; bone marrow; CM; conditioned medium; mPGES-1; microsomal prostaglandin E2 synthase-1; cPGES-1; cytosolic prostaglandin E2 synthase; H-PGDS; hematopoietic
Development of 2-aryl substituted quinazolin-4(3H)-one, pyrido[4,3-d]pyrimidin-4(3H)-one and pyrido[2,3-d]pyrimidin-4(3H)-one derivatives as microsomal prostaglandin E2 synthase-1 inhibitors
Keywords: Analgesic; Cyclooxygenase; Prostaglandin E2; mPGES-1; Quinazolinone
A semi-synthetic derivative of artemisinin, artesunate inhibits prostaglandin E2 production in LPS/IFNγ-activated BV2 microglia
Keywords: Artesunate; Microglia; PGE2; COX-2; mPGES-1; NF-κB; p38 MAPK
Identification of pirinixic acid derivatives bearing a 2-aminothiazole moiety combines dual PPARα/γ activation and dual 5-LO/mPGES-1 inhibition
Keywords: PPARα; PPARγ; Inflammation; 5-LO; mPGES-1; Cancer;
15d-PGJ2 decreases PGE2 synthesis in HBx-positive liver cells by interfering EGR1 binding to mPGES-1 promoter
Keywords: Early growth response 1 (EGR1); Microsomal prostaglandin E synthase 1 (mPGES-1); Promoter; HBV X protein (HBx); Hepatocyte; HBV; Hepatitis B virus; HCC; hepatocellular carcinoma; HBx; HBV X protein; PGE2; prostaglandin E2; COX; cyclooxygenase; mPGES-1; mi
Mechanisms of anti-inflammatory property of Anacardium occidentale stem bark: Inhibition of NF-κB and MAPK signalling in the microglia
Keywords: Anacardium occidentale; NF-κB; MAPK; COX-2; iNOS; mPGES-1;
Hydrogen sulfide inhibits preoptic prostaglandin E2 production during endotoxemia
Keywords: 3V; third ventricle; AOA; aminooxyacetate; AVPO; anteroventral preoptic region; cAMP; cyclic adenosine monophosphate; CBS; cystathionine β-synthase; cGMP; cyclic guanosine monophosphate; COX; cyclooxygenase; CSE; cystathionine γ-lyase; icv; intracerebro
7-Phenyl-imidazoquinolin-4(5H)-one derivatives as selective and orally available mPGES-1 inhibitors
Keywords: mPGES-1; PGE2; Imidazoquinolin-4(5H)-one; Oral absorption;
Synthesis and biological evaluation of substituted imidazoquinoline derivatives as mPGES-1 inhibitors
Keywords: mPGES-1; PGE2; Imidazoquinoline; Selective alkylation;
Fragment-based discovery of novel and selective mPGES-1 inhibitors Part 1: Identification of sulfonamido-1,2,3-triazole-4,5-dicarboxylic acid
Keywords: Fragment-based discovery; mPGES-1; Partial nuisance inhibitor; Inflammation; Triton X-100; Sulfonamido triazole-4,5-dicarboxylic acid;
Novel benzoxazole inhibitors of mPGES-1
Keywords: mPGES-1; Benzoxazole; Selective
Synthesis and biological evaluation of substituted benzoxazoles as inhibitors of mPGES-1: Use of a conformation-based hypothesis to facilitate compound design
Keywords: mPGES-1; Benzoxazole; Solubility; Acyl glucuronide; Conformational analysis
Genetic deletion of microsomal prostaglandin E synthase-1 suppresses mouse mammary tumor growth and angiogenesis
Keywords: Mouse; mPGES-1; Breast cancer; Aromatase; Angiogenesis; PGE2
Effects of mPGES-1 deletion on eicosanoid and fatty acid profiles in mice
Keywords: mPGES-1; Prostaglandins E2; Eicosanoids; Fatty acids; Knock-out mice; Inflammation
Characterization of a human and murine mPGES-1 inhibitor and comparison to mPGES-1 genetic deletion in mouse models of inflammation
Keywords: mPGES-1; Inflammation; Mouse; PGE2; Macrophages; Air pouch model
Prostanoids and inflammatory pain
Keywords: Inflammatory pain; COX-2; PGE2; PGI2; mPGES-1; Peripheral sensitization; Central sensitization
Synthesis and SAR study of imidazoquinolines as a novel structural class of microsomal prostaglandin E2 synthase-1 inhibitors
Keywords: mPGES-1; PGE2; Imidazoquinoline; COX-1; COX-2;