7-Phenyl-imidazoquinolin-4(5H)-one derivatives as selective and orally available mPGES-1 inhibitors
Keywords: جذب دهانی; mPGES-1; PGE2; Imidazoquinolin-4(5H)-one; Oral absorption;
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Analysis of the enhanced oral bioavailability of fenofibrate lipid formulations in fasted humans using an in vitro-in silico-in vivo approach
Keywords: جذب دهانی; Fenofibrate; Lipid-based formulation; Biorelevant dissolution tests; Permeability; Oral absorption; Physiologically based pharmacokinetic model;
Porous starch based self-assembled nano-delivery system improves the oral absorption of lipophilic drug
Keywords: جذب دهانی; Porous starch; Self-assembly; Nanoparticles; Oral absorption; Probucol
Liquid and solid self-microemulsifying drug delivery systems for improving the oral bioavailability of andrographolide from a crude extract of Andrographis paniculata
Keywords: جذب دهانی; Andrographolide; Andrographis paniculata; SMEDDS; Self-microemulsifying drug delivery systems; Oral absorption
Comparative study of Pluronic® F127-modified liposomes and chitosan-modified liposomes for mucus penetration and oral absorption of cyclosporine A in rats
Keywords: جذب دهانی; Mucus penetration; Oral absorption; Pluronic® F127; Chitosan; Liposomes; Cyclosporine A
Involvement of Carnitine/Organic Cation Transporter OCTN1/SLC22A4 in Gastrointestinal Absorption of Metformin
Keywords: جذب دهانی; oral absorption; organic cation transporter; pharmacokinetics; ADME; drug transport; renal excretion
The Effect of Administered Dose of Lipid-Based Formulations on the In Vitro and In Vivo Performance of Cinnarizine as a Model Poorly Water-Soluble Drug
Keywords: جذب دهانی; lipid-based formulation; poorly water-soluble drugs; lipid-based drug delivery system; medium-chain triacylglyceride; long-chain triacylglyceride; lipids; oral absorption; formulation; bioavailability; in vitro model;
The Impact of Lymphatic Transport on the Systemic Disposition of Lipophilic Drugs
Keywords: جذب دهانی; absorption; clearance; disposition; distribution; lipids; lipoproteins; lymphatic transport; oral absorption; pharmacokinetics; intravenous;
Keeping a Critical Eye on the Science and the Regulation of Oral Drug Absorption: A Review
Keywords: جذب دهانی; gastrointestinal transit; solubility; permeability; oral absorption; bioavailability; bioequivalence; ADME; BCS; BDDCS
Accounting for the solubility–permeability interplay in oral formulation development for poor water solubility drugs: The effect of PEG-400 on carbamazepine absorption
Keywords: جذب دهانی; Drug solubility; Intestinal permeability; Oral absorption; Solubility-enabling formulations; Solubility–permeability tradeoff
In vitro investigations of α-amylase mediated hydrolysis of cyclodextrins in the presence of ibuprofen, flurbiprofen, or benzo[a]pyrene
Keywords: جذب دهانی; Cyclodextrins; Amylase; Digestion; Bioavailability; Oral absorption; Inclusion complexes;
Stabilized micelles as delivery vehicles for paclitaxel
Keywords: جذب دهانی; Stabilized micelles; Paclitaxel; Pluronic; Gastrointestinal transit; Oral absorption;
In Vitro and In Vivo Evaluation of a Sulfenamide Prodrug of Basic Metformin
Keywords: جذب دهانی; bioavailability; Caco-2 cells; in vitro/in vivo correlations (IVIVC); log P; oral absorption; permeability; prodrugs;
Microdosing: A Critical Assessment of Human Data
Keywords: جذب دهانی; pharmacokinetics; bioavailability; biopharmaceutical drug disposition classification system (BDDCS); oral absorption; PET; physiological model;
Characterization and evaluation of self-microemulsifying sustained-release pellet formulation of puerarin for oral delivery
Keywords: جذب دهانی; Puerarin; SMEDDS; Sustained-release pellet; Oral absorption; Bioavailability;
Supersaturation-Nucleation Behavior of Poorly Soluble Drugs and its Impact on the Oral Absorption of Drugs in Thermodynamically High-Energy Forms
Keywords: جذب دهانی; supersaturation; nucleation; precipitation; oral absorption; high-energy form; solubility; in vitro/in vivo correlation;
Skin Microdialysis-Based Estimation of Systemic Bioavailability Fraction
Keywords: جذب دهانی; bioavailability; dose-proportionality; microdialysis; pharmacokinetics; oral absorption; tissue partition;
Size-dependent absorption mechanism of polymeric nanoparticles for oral delivery of protein drugs
Keywords: جذب دهانی; Polymeric nanoparticles; Particle size; Oral absorption; Uptake; Transport; BiodistributionAPS, ammonium persulfate; CC, carboxylated chitosan; CCNP, carboxylated chitosan grafted nanoparticles; FAE, follicle-associated epithelium; FITC-BSA, FITC labeled
The impact of training set data distributions for modelling of passive intestinal absorption
Keywords: جذب دهانی; Intestinal absorption; QSAR; Oral absorption; Training set; Regression; Classification;
Biowaiver Approach for Biopharmaceutics Classification System Class 3 Compound Metformin Hydrochloride Using In Silico Modeling
Keywords: جذب دهانی; oral absorption; Biopharmaceutics Classification System (BCS); mathematical model; dissolution; permeability;
Gastric pH and Gastric Residence Time in Fasted and Fed Conscious Beagle Dogs using the Bravo® pH System
Keywords: جذب دهانی; gastrointestinal transit; residence time; transit time; food effects; oral absorption; Bravo® capsule; gastrointestinal pH; dog;
Evaluation of Drug Supersaturation by Thermodynamic and Kinetic Approaches for the Prediction of Oral Absorbability in Amorphous Pharmaceuticals
Keywords: جذب دهانی; supersaturation; amorphous; crystallization; thermodynamics; kinetics; oral absorption; in vitro-in vivo correlation;
Oral Coadministration of β-Glucuronidase to Increase Exposure of Extensively Glucuronidated Drugs that Undergo Enterohepatic Recirculation
Keywords: جذب دهانی; β-glucuronidase; enterohepatic circulation; glucuronidation; site-specific delivery; intestinal metabolism; oral absorption; ADME; pharmacokinetics; intestinal absorption; bioavailability;
Microfabrication technologies for oral drug delivery
Keywords: جذب دهانی; Microfabrication; Microdevices; Microfluidics; Oral drug delivery; Oral absorption; In vitro models
Interindividual Variation in Transdermal and Oral Drug Deliveries
Keywords: جذب دهانی; Interindividual Variation; Percutaneous absorption; Drug delivery systems; Drug transport; Oral absorption; Oral drug delivery; Pharmacokinetics/pharmacodynamics; Transdermal; Transdermal drug delivery; Partition coefficient.;
In vitro models to evaluate the permeability of poorly soluble drug entities: Challenges and perspectives
Keywords: جذب دهانی; In vitro; Poorly soluble; Oral absorption; Permeability; Solubiliser
Study on in situ and in vivo absorption kinetics of phenytoin by modulating P-glycoprotein with verapamil in rats
Keywords: جذب دهانی; Phenytoin; Verapamil; P-glycoprotein; Permeability; Oral absorption; Single pass intestinal perfusion technique
Chitosan nanoparticles enhance the plasma exposure of (−)-epigallocatechin gallate in mice through an enhancement in intestinal stability
Keywords: جذب دهانی; (−)-Epigallocatechin gallate (EGCG); Oral absorption; Plasma exposure; Chitosan-tripolyphosphate nanoparticles (CS NPs); Intestinal stability
Nanoemulsion improves the oral absorption of candesartan cilexetil in rats: Performance and mechanism
Keywords: جذب دهانی; Candesartan cilexetil; Candesartan; Nanoemulsion; Oral absorption
Estimation of P-glycoprotein-mediated efflux in the oral absorption of P-gp substrate drugs from simultaneous analysis of drug dissolution and permeation
Keywords: جذب دهانی; Oral absorption; P-glycoprotein; In vitro–in vivo correlation; Drug–drug interaction; Cremophor EL
Formulation Optimization and Bioavailability After Oral and Nasal Administration in Rabbits of Puerarin-Loaded Microemulsion
Keywords: جذب دهانی; microemulsion; formulation; bioavailability; oral absorption; nasal absorption; puerarin;
Nanonization of Itraconazole by High Pressure Homogenization: Stabilizer Optimization and Effect of Particle Size on Oral Absorption
Keywords: جذب دهانی; nanosuspensions; multiple stabilizer system; central composite design; itraconazole; dissolution; oral absorption;
Preclinical pharmacokinetic evaluation of resveratrol trimethyl ether in sprague-dawley rats: the impacts of aqueous solubility, dose escalation, food and repeated dosing on oral bioavailability
Keywords: جذب دهانی; Resveratrol; Resveratrol trimethyl ether; Oral absorption; Pharmacokinetics; Bioavailability; Dose proportionality; Repeated dosing; Solubility; Cyclodextrins;
Biopharmaceutical Characterization of Ciprofloxacin HCl-Ferrous Sulfate Interaction
Keywords: جذب دهانی; bioavailability; Biopharmaceutics Classification System (BCS); ciprofloxacin HCl; dissolution; drug interaction; in silico modeling; ferrous sulfate; oral absorption; solubility;
Oral Apomorphine Delivery from Solid Lipid Nanoparticles with Different Monostearate Emulsifiers: Pharmacokinetic and Behavioral Evaluations
Keywords: جذب دهانی; apomorphine; oral absorption; bioavailability; nanoparticles; pharmacokinetics; drug transport;
Studies on Binary Lipid Matrix Based Solid Lipid Nanoparticles of Repaglinide: in Vitro and in Vivo Evaluation
Keywords: جذب دهانی; Nanoparticles; lipids; first-pass metabolism; stability; bioavailability; morphology; particle size; biodegradable; oral absorption; intestinal lymphatic route;
Multidisciplinary Approach on Characterizing a Mechanochemically Activated Composite of Vinpocetine and Crospovidone
Keywords: جذب دهانی; vinpocetine; solid state; mechanical activation; micronized crospovidone; oral absorption; physical characterization; nanocrystals; PXRD; SS-NMR; Raman spectroscopy/imaging;
Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1: Oral solutions
Keywords: جذب دهانی; modeling; simulation; prediction; gastrointestinal tract; absorption; pharmacokinetics; PBPK; computational ADME; mathematical models; oral absorption;
PhRMA CPCDC Initiative on Predictive Models of Human Pharmacokinetics, Part 1: Goals, Properties of the Phrma Dataset, and Comparison with Literature Datasets
Keywords: جذب دهانی; allometry; bioavailability; clearance; computational ADME; first-in-human; pharmacokinetics; oral absorption; PhRMA; PBPK; volume of distribution;
Possible reduction of effective thickness of intestinal unstirred water layer by particle drifting effect
Keywords: جذب دهانی; Oral absorption; Particle size; Unstirred water layer; Permeability
Bioadhesion and oral absorption of enoxaparin nanocomplexes
Keywords: جذب دهانی; Chitosan; Thiolated chitosan; Trimethyl chitosan; PEGylation; Enoxaparin; Polyelectrolyte complex; Bioadhesion; Oral absorption
Prediction of food effect by bile micelles on oral drug absorption considering free fraction in intestinal fluid
Keywords: جذب دهانی; Solubility; Permeability; Dissolution; Oral absorption; Food effect; Bile micelles; Simulation; Free fraction; Unstirred water layer
Reciprocal competition between lipid nanocapsules and P-gp for paclitaxel transport across Caco-2 cells
Keywords: جذب دهانی; Nanoparticle; P-gp; Paclitaxel; Oral absorption; Drug resistance
Enhanced absorption of the poorly soluble drug fenofibrate by tuning its release rate from ordered mesoporous silica
Keywords: جذب دهانی; Fenofibrate; Supersaturation; Oral absorption; Ordered mesoporous silica; SBA-15; MCM-41
IVIVC for Fenofibrate Immediate Release Tablets Using Solubility and Permeability as In Vitro Predictors for Pharmacokinetics
Keywords: جذب دهانی; in vitro/in vivo correlations (IVIVC); bioavailability; solubility; oral absorption; surfactants;
Computational oral absorption simulation of free base drugs
Keywords: جذب دهانی; Free base; Solubility; Dissolution rate; Computational simulation; Oral absorption
Development and evaluation of self-microemulsifying liquid and pellet formulations of curcumin, and absorption studies in rats
Keywords: جذب دهانی; Curcumin; Self-microemulsifying drug delivery systems; SMEDDS; Oral absorption; Pellets
Interactions between the flavonoid biochanin A and P-glycoprotein substrates in rats: In vitro and in vivo
Keywords: جذب دهانی; ABC transporters; pharamcokinetics; P-glycoprotein; drug transport; oral absorption;
The Developability Classification System: Application of Biopharmaceutics Concepts to Formulation Development
Keywords: جذب دهانی; biopharmaceutics classification system (BCS); bioequivalence; oral absorption; developability; biorelevant media; solubility; permeability; dissolution rate;
Physiologically Based Predictions of the Impact of Inhibition of Intestinal and Hepatic Metabolism on Human Pharmacokinetics of CYP3A Substrates
Keywords: جذب دهانی; physiological model; pharmacokinetics; oral absorption; first-pass effect; cytochrome P450; drug interactions; inhibition;