دانلود مقالات ISI درباره جذب دهانی + ترجمه فارسی

Introduction to the OrBiTo decision tree to select the most appropriate in vitro methodology for release testing of solid oral dosage forms during development

Keywords: جذب دهانی; Dissolution; Decision tree; Formulation; Oral absorption; PBPK; Biopharmaceutics classification system (BCS);

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2018 سفارش ترجمه

In Vitro-In Vivo Evaluation of an Oral Ghost Drug Delivery Device for the Delivery of Salmon Calcitonin

Keywords: جذب دهانی; oral absorption; peptide delivery; pharamcokinetics; proteins; drug transport; polymer synthesis; OGDD; Oral Ghost Drug Delivery; UHMW-PE; ultra-high-molecular-weight polyethylene; AAm; polyethylene: acrylamide monomers; MAA; methyacrylic acid; BIS; N-N

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2018 سفارش ترجمه

Design, synthesis, and biological evaluation of novel biphenyl-4-carboxamide derivatives as orally available TRPV1 antagonists

Keywords: جذب دهانی; TRPV1 antagonist; Neuropathic pain; Agonist; Biphenyl-4-carboxamide; Oral absorption;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2018 سفارش ترجمه

Multi-purposable filaments of HPMC for 3D printing of medications with tailored drug release and timed-absorption

Keywords: جذب دهانی; Three-dimensional printing; Drug release; Dissolution; Oral absorption; Filaments; HPMC;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2018 سفارش ترجمه

Solid lipid nanoparticles as carriers for oral delivery of hydroxysafflor yellow A

Keywords: جذب دهانی; Solid lipid nanoparticle; Hydroxysafflor yellow A; Oral absorption; Pharmacokinetics; Cerebral ischemia;

دانلود رایگان متن کامل مقاله ISI 27 صفحه سال انتشار : 2018 سفارش ترجمه

Formulation predictive dissolution (fPD) testing to advance oral drug product development: An introduction to the US FDA funded '21st Century BA/BE' project

Keywords: جذب دهانی; In vivo dissolution; Bioequivalence; Bioavailability; Oral absorption; MRI; Manometry; Computational fluid dynamics;

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2018 سفارش ترجمه

Enhanced digestion inhibition and mucus penetration of F127-modified self-nanoemulsions for improved oral delivery

Keywords: جذب دهانی; Self-nanoemulsifying system (SNEs); Oral absorption; Enzymatic degradation; Mucus penetration; Pluronic® F127;

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2018 سفارش ترجمه

PLGA nanoparticles are effective to control the colonic release and absorption on ibuprofen

Keywords: جذب دهانی; Colon permeability; Controlled release; Ibuprofen; Oral absorption; PLGA nanoparticles;

دانلود رایگان متن کامل مقاله ISI 34 صفحه سال انتشار : 2018 سفارش ترجمه

Amorphous Solid Dispersion of Meloxicam Enhanced Oral Absorption in Rats With Impaired Gastric Motility

Keywords: جذب دهانی; amorphous; drug-excipient interaction; gastrointestinal transit; oral absorption; poorly water-soluble drugs; solid dispersion; AUC; area under the curve of blood concentration versus time curve; ASD-MEL/EUD; amorphous solid dispersion of meloxicam with p

دانلود رایگان متن کامل مقاله ISI 34 صفحه سال انتشار : 2018 سفارش ترجمه

A physiologically based pharmacokinetic model for valacyclovir established based on absolute expression quantity of hPEPT1 and its application

Keywords: جذب دهانی; Valacyclovir (PubChem CID: 60773); acyclovir (PubChem CID: 2022); PBPK model; Absolute expression quantity of transporter; Valacyclovir; in vivo pharmacokinetics; Oral absorption; hPEPT1;

دانلود رایگان متن کامل مقاله ISI 37 صفحه سال انتشار : 2018 سفارش ترجمه

A Biopredictive In Vitro Comparison of Oral Locally Acting Mesalazine Formulations by a Novel Dissolution Model for Assessing Intraluminal Drug Release in Individual Subjects

Keywords: جذب دهانی; bioavailability; colonic drug delivery; controlled release; dissolution; gastrointestinal transit; in vitro models; oral absorption; residence time; site-specific delivery; solubility;

دانلود رایگان متن کامل مقاله ISI 38 صفحه سال انتشار : 2018 سفارش ترجمه

Effect of biphenyl hydrolase-like (BPHL) gene disruption on the intestinal stability, permeability and absorption of valacyclovir in wildtype and Bphl knockout mice

Keywords: جذب دهانی; ABHD14A; alpha/beta hydrolase domain containing 14a; ABHD14B; alpha/beta hydrolase domain containing 14b; ACV; acyclovir; Bphl; biphenyl hydrolase-like protein; KO; knockout; PepT1; peptide transporter 1 (SLC15a1); PepT2; peptide transporter 2 (SLC15a2);

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2018 سفارش ترجمه

Developing Quantitative In Vitro-In Vivo Correlation for Fenofibrate Immediate-Release Formulations With the Biphasic Dissolution-Partition Test Method

Keywords: جذب دهانی; fenofibrate; in vitro models; in vitro-in vivo correlation (IVIVC); oral absorption; bioavailability; clinical pharmacokinetics; dissolution; partition; biphasic; poorly water soluble drugs; BCS;

دانلود رایگان متن کامل مقاله ISI 47 صفحه سال انتشار : 2018 سفارش ترجمه

In Vitro-In Vivo Correlations of Carbamazepine Nanodispersions for Application in Formulation Development

Keywords: جذب دهانی; dissolution; absorption; in vitro-in vivo correlations (IVIVC); in vitro models; nanoparticles; amorphous; oral absorption; bioavailability; solid dispersion;

دانلود رایگان متن کامل مقاله ISI 48 صفحه سال انتشار : 2018 سفارش ترجمه

Food effect: The combined effect of media pH and viscosity on the gastrointestinal absorption of ciprofloxacin tablet

Keywords: جذب دهانی; Corchorus olitorius; Food effect; Ciprofloxacin; Viscosity; Oral absorption; Physiological modeling;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Development of sesamin-loaded solid dispersion with α-glycosylated stevia for improving physicochemical and nutraceutical properties

Keywords: جذب دهانی; ANOVA; one-way analysis of variance; DSC; differential scanning calorimetry; ESI; electric spray ionization; Hesperidin-G; α-glycosylated hesperidin; PLM; polarized light microscopy; RH; relative humidity; Rutin-G; α-glycosylated rutin; SD; solid disper

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Polyarginine Nanocapsules as a Potential Oral Peptide Delivery Carrier

Keywords: جذب دهانی; nanotechnology; nanocapsules; colloid; biodegradable polymers; biomaterials; cancer; Caco-2 cells; oral drug delivery; oral absorption; surfactants;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Contribution of M-cells and other experimental variables in the translocation of TiO2 nanoparticles across in vitro intestinal models

Keywords: جذب دهانی; Caco-2; Raji B; M-cell; Oral absorption; TiO2 nanoparticles;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Full Length ArticleRational design of hybrid nanomicelles integrating mucosal penetration and P-glycoprotein inhibition for efficient oral delivery of paclitaxel

Keywords: جذب دهانی; TPGS-succinic acid-mercaptoethylamine; Hybrid nanomicelles; P-glycoprotein inhibition; Mucosal penetration; Oral absorption; Paclitaxel;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Cocrystal solubility product analysis - Dual concentration-pH mass action model not dependent on explicit solubility equations

Keywords: جذب دهانی; Solubility-pH; Cocrystal solubility product; Salt solubility product; Mass action model; Sparingly-soluble drugs; Oral absorption;

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2017 سفارش ترجمه

Water-Soluble Combretastatin A4 Phosphate Orally Delivered via Composite Nanoparticles With Improved Inhibition Effect Toward S180 Tumors

Keywords: جذب دهانی; combretastatin A4 phosphate; nanoparticles; oral absorption; bioavailability; cancer therapy;

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2017 سفارش ترجمه

Hexagonal Liquid Crystalline Nanodispersions Proven Superiority for Enhanced Oral Delivery of Rosuvastatin: In Vitro Characterization and In Vivo Pharmacokinetic Study

Keywords: جذب دهانی; solubility; pharmacokinetics; oral absorption; lipids; intestinal permeation; bioavailability;

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2017 سفارش ترجمه

Self-Assembled Core-Shell-Type Lipid-Polymer Hybrid Nanoparticles: Intracellular Trafficking and Relevance for Oral Absorption

Keywords: جذب دهانی; endocytosis; drug transport; oral absorption; poly(lactic-co-glycolic acid) nanoparticles; saquinavir;

دانلود رایگان متن کامل مقاله ISI 36 صفحه سال انتشار : 2017 سفارش ترجمه

Hybridization of polyvinylpyrrolidone to a binary composite of curcumin/α-glucosyl stevia improves both oral absorption and photochemical stability of curcumin

Keywords: جذب دهانی; CUR; curcumin; DSC; differential scanning calorimetry; Hesperidin-G; α-glucosyl hesperidin; PM; physical mixture; PVP; polyvinylpyrrolidone; PXRD; powder X-ray diffraction; RH; relative humidity; Rutin-G; α-glucosyl rutin; Stevia-G; α-glucosyl stevia;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Suitability of the in vitro Caco-2 assay to predict the oral absorption of aromatic amine hair dyes

Keywords: جذب دهانی; AEP; 2-amino-5-ethylphenol; CEN; 2-chloro-6-ethylamino-4-nitrophenol; HAP; 4-hydroxypropylamino-3-nitrophenol; APB; HC Blue 16; HCR; HC Red no 13; HCY; HC Yellow no 13; HDAP; 1-hydroxyethyl-4,5-diamino pyrazole; ACP; 2-amino-6-chloro-4-nitrophenol; AHT; 4

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Effect of Absorption Behavior of Solubilizers on Drug Dissolution in the Gastrointestinal Tract: Evaluation Based on In Vivo Luminal Concentration-Time Profile of Cilostazol, a Poorly Soluble Drug, and Solubilizers

Keywords: جذب دهانی; bioequivalence; dissolution; oral absorption; poorly water-soluble drugs; solubility; AUCGI(drug); area under the luminal concentration-time curve of drug; AUCGI(FD-4); area under the luminal concentration-time curve of FD-4; BCS; Biopharmaceutics Cla

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Development of a novel l-sulpiride-loaded quaternary microcapsule: Effect of TPGS as an absorption enhancer on physicochemical characterization and oral bioavailability

Keywords: جذب دهانی; l-sulpiride; Quaternary microcapsule; d-α-tocopheryl polyethylene glycol 1000 succinate; Oral absorption; Administered drug dose;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Supersaturation and Precipitation of Posaconazole Upon Entry in the Upper Small Intestine in Humans

Keywords: جذب دهانی; supersaturation; precipitation; oral drug delivery; intestinal absorption; clinical pharmacokinetics; gastrointestinal; absorption; formulation; biopharmaceutics classification system; oral absorption;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Development of pH-Independent Drug Release Formulation Using Lipocalin-Type Prostaglandin D Synthase

Keywords: جذب دهانی; solubility; spray drying; absorption enhancer; formulation vehicle; dissolution; oral absorption; oral drug delivery; proteins;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Nanocomposites based on Soluplus and Angelica gigas Nakai extract fabricated by an electrohydrodynamic method for oral administration

Keywords: جذب دهانی; Angelica gigas Nakai; Electrohydrodynamic process; Nanocomposite; Oral absorption; Soluplus;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Gastrointestinal and Systemic Monitoring of Posaconazole in Humans After Fasted and Fed State Administration of a Solid Dispersion

Keywords: جذب دهانی; supersaturation; precipitation; intestinal absorption; clinical pharmacokinetics; gastrointestinal; absorption; biopharmaceutics classification system; oral absorption; solid dispersion; amorphous;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Influence of surfactants in self-microemulsifying formulations on enhancing oral bioavailability of oxyresveratrol: Studies in Caco-2 cells and in vivo

Keywords: جذب دهانی; Self-microemulsifying drug delivery system; SMEDDS; Surfactants; Caco-2 cells; Oral absorption; Oxyresveratrol

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

The Proteome of Filter-Grown Caco-2 Cells With a Focus on Proteins Involved in Drug Disposition

Keywords: جذب دهانی; proteomics; caco-2 cells; permeability; transporters; ABC transporters; solute transporters; epithelial delivery/permeability; oral absorption; tight junction in vitro/in vivo correlations;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

A Minireview: Usefulness of Transporter-Targeted Prodrugs in Enhancing Membrane Permeability

Keywords: جذب دهانی; prodrugs; transporters; Biopharmaceutics Classification System; permeability; solubility; peptide transporter; P-glycoprotein; oral absorption;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

Comparison of solventâ¿¿wetted and kneaded l-sulpirideâ¿¿loaded solid dispersions: Powder characterization and in vivo evaluation

Keywords: جذب دهانی; l-Sulpiride; TPGS-based solid dispersion; Solventâ¿¿wetted; Kneaded; Oral absorption;

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2016 سفارش ترجمه

The use of captisol (SBE7-β-CD) in oral solubility-enabling formulations: Comparison to HPβCD and the solubility–permeability interplay

Keywords: جذب دهانی; Cyclodextrins; Intestinal permeability; Oral absorption; Solubility enabling formulation; Solubility–permeability tradeoff

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Improved oral absorption of dutasteride via Soluplus®-based supersaturable self-emulsifying drug delivery system (S-SEDDS)

Keywords: جذب دهانی; Dutasteride; Supersaturable self-emulsifying drug delivery system; Soluplus®; Oral absorption; Bioavailability

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Bioactive Self-Assembling Lipid-Like Peptides as Permeation Enhancers for Oral Drug Delivery

Keywords: جذب دهانی; lipid-like peptides; surfactant; designed tunable peptides; oral absorption; epithelial delivery; Caco-2 cells; absorption enhancer; formulation; intestinal absorption; macromolecular drug delivery; everted sacs;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Design of Fexofenadine Prodrugs Based on Tissue-Specific Esterase Activity and Their Dissimilar Recognition by P-Glycoprotein

Keywords: جذب دهانی; bioavailability; membrane transport; metabolism; oral absorption; P-glycoprotein; prodrugs

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

VB12-coated Gel-Core-SLN containing insulin: Another way to improve oral absorption

Keywords: جذب دهانی; Insulin; Gel-Core-SLN; Vitamin B12; Double emulsion technology; Oral Absorption

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Targeted Delivery of NK007 to Macrophages to Treat Colitis

Keywords: جذب دهانی; macrophage; targeted drug delivery; colonic drug delivery; oral absorption; encapsulation; biodegradable polymers; colitis; inflammatory cytokine; glucan particle;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Zidovudine-Poly(l-Lactic Acid) Solid Dispersions with Improved Intestinal Permeability Prepared by Supercritical Antisolvent Process

Keywords: جذب دهانی; supercritical antisolvent process; supercritical fluids; zidovudine; poly(l-lactic acid); solid dispersion; oral absorption; gas trointestinal transit; everted rat intestinal sacs; permeability;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Discovery of WQ-3810: Design, synthesis, and evaluation of 7-(3-alkylaminoazetidin-1-yl)fluoro-quinolones as orally active antibacterial agents

Keywords: جذب دهانی; Antibacterial agent; Fluoroquinolone; Gram-negative bacteria; Oral absorption; Alkylaminoazetidine; YJRFYAWJFKONJD-UHFFFAOYSA-N; XIQHTMHVFRRPKO-UHFFFAOYSA-N; UMIUJKXRGOKQSJ-UHFFFAOYSA-N; QYWWAPQGCKJESQ-UHFFFAOYSA-N; MJMVUQNNSOBCGF-UHFFFAOYSA-N; HUDDGSWMGN

دانلود رایگان متن کامل مقاله ISI 56 صفحه سال انتشار : 2015 سفارش ترجمه

In vivo proof of concept of oral insulin delivery based on a co-administration strategy with the cell-penetrating peptide penetratin

Keywords: جذب دهانی; Cell-penetrating peptides; Penetratin; Insulin; Oral absorption; Pharmacological availability

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Orally Administered DTPA Penta-Ethyl Ester for the Decorporation of Inhaled 241Am

Keywords: جذب دهانی; ADME; chelation; oral absorption; pharmacokinetics; prodrugs;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Phytic acid enhances the oral absorption of isorhamnetin, quercetin, and kaempferol in total flavones of Hippophae rhamnoides L.

Keywords: جذب دهانی; Phytic acid; Oral absorption; Solubility; Permeability; Flavonoids; Absorption enhancer;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Preclinical Pharmacokinetics and In Vitro Metabolism of BMS-605339: A Novel HCV NS3 Protease Inhibitor

Keywords: جذب دهانی; preclinical pharmacokinetics; oral absorption; metabolism; hepatic clearance; in vitro/in vivo correlations (IVIVC); ADME; protease;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

The interaction of nifedipine with selected cyclodextrins and the subsequent solubility-permeability trade-off

Keywords: جذب دهانی; Low-solubility drugs; Intestinal permeability; Oral absorption; Cyclodextrins; Solubility-enabling formulations; Solubility-permeability interplay;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

P-glycoprotein is responsible for the poor intestinal absorption and low toxicity of oral aconitine: In vitro, in situ, in vivo and in silico studies

Keywords: جذب دهانی; Aconitine; P-glycoprotein; Oral absorption; Caco-2 cells; MDCKII-MDR1 cells; In situ intestinal perfusion;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Polymeric nanocapsules with SEDDS oil-core for the controlled and enhanced oral absorption of cyclosporine

Keywords: جذب دهانی; Nanocapsules; SEDDS oil-core; Polymer shell; Poly-dl-lactide; Cyclosporine; Oral absorption;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه